| UniProt/SwissProt ID: | ADAP1_HUMAN |
| Description: | ArfGAP with dual PH domains 1 [Source:HGNC Symbol;Acc:16486] |
| Location: | chr7 p22.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T276 | RKRWFtMDDRR | PH | PhosphoSitePlus |
| Y232 | AARFHyLQVAF | PhosphoSitePlus | |
| S87 | RARFEsKVPSF | PRKCA | HPRD |
| S87 | RARFEsKVPSF | PRKCE | HPRD |
| T276 | RKRWFtMDDRR | PRKCE | HPRD |
| S87 | RARFEsKVPSF | ArfGap | PhosphoSitePlus |
| Y284 | DRRLMyFKDPL | PH | PhosphoSitePlus |
| T276 | RKRWFtMDDRR | PRKCA | HPRD |
| Dephosphorylation site |
| ADAP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000265846 | R110Q | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000265846 | R110Q | COSMIC | Head and Neck Cancer | 21798897 |
| Differential expressed protein |
| ADAP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ADAP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | ADAP1_HUMAN | kinase -> substrate | HPRD |
| KPCE_HUMAN | ADAP1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| ADAP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding | TAS | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0043087 | regulation of GTPase activity | IMP | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0032312 | regulation of ARF GTPase activity | IEA | biological_process |
| GO:0008060 | ARF GTPase activator activity | IDA | molecular_function |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |