| UniProt/SwissProt ID: | IF4G3_HUMAN |
| Description: | eukaryotic translation initiation factor 4 gamma, 3 [Source:HGNC Symbol;Acc:3298] |
| Location: | chr1 p36.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1409 | FIESDsPCSSE | PhosphoSitePlus; HPRD; phosphoELM | |
| S1157 | MRGGSsKDLLD | PhosphoSitePlus | |
| S267 | LPLPPsPTTVS | RegPhos | |
| S1343 | LTIEFsKPLLP | HPRD | |
| S495 | LNSRRsPVPAQ | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S1156 | FMRGGsSKDLL | PhosphoSitePlus | |
| T168 | GSRNPtPPIGR | PhosphoSitePlus | |
| S232 | VLKSPsPVLRL | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S1128 | RRTLTsRGSMG | PhosphoSitePlus | |
| S1218 | DKAALsEEELE | PhosphoSitePlus | |
| S1190 | DVERNsTEAER | PhosphoSitePlus | |
| S1165 | LLDNQsQEEQR | PhosphoSitePlus | |
| S1156 | FMRGGsSKDLL | CAMK1 | HPRD |
| S1131 | LTSRGsMGREK | PhosphoSitePlus | |
| S1582 | EAEEEsEDN__ | W2 | PhosphoSitePlus |
| S1112 | PAPSGsTPSTP | PhosphoSitePlus | |
| T1116 | GSTPStPVEFD | PhosphoSitePlus | |
| T1198 | AERNKtRESAK | PhosphoSitePlus | |
| T1113 | APSGStPSTPV | PhosphoSitePlus | |
| S240 | LRLVLsGEKKE | PhosphoSitePlus; HPRD | |
| T518 | KDRTRtTEEML | PhosphoSitePlus | |
| S230 | DPVLKsPSPVL | PhosphoSitePlus; HPRD; RegPhos | |
| S889 | KARRRsIGNIK | MIF4G | PhosphoSitePlus |
| S1156 | FMRGGsSKDLL | CaMK1a | RegPhos |
| T1191 | VERNStEAERN | PhosphoSitePlus | |
| Dephosphorylation site |
| IF4G3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000264211 | R963K | COSMIC | Melanoma | 21499247 | ENSP00000264211 | Q1166E | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| IF4G3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IF4G3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KCC1A_HUMAN | IF4G3_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | IF4G3_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03013 | RNA transport |
| hsa05416 | Viral myocarditis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0003743 | translation initiation factor activity | IEA | molecular_function |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0016070 | RNA metabolic process | IEA | biological_process |
| GO:0016281 | eukaryotic translation initiation factor 4F comple | TAS | cellular_component |
| GO:0007283 | spermatogenesis | IEA | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0007128 | meiotic prophase I | IEA | biological_process |
| GO:0008135 | translation factor activity, nucleic acid binding | TAS | molecular_function |
| GO:0006446 | regulation of translational initiation | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0045727 | positive regulation of translation | IEA | biological_process |
| GO:0000339 | RNA cap binding | TAS | molecular_function |