Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRAK1_HUMAN
Description:interleukin-1 receptor-associated kinase 1 [Source:HGNC Symbol;Acc:6112]
Location:chrX q28
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S568PLAAPsGASAQPhosphoSitePlus; phosphoELM; RegPhos
S376SPSQSsMVARTPkinasePhosphoSitePlus
T66RSGQRtASVLWRAMP; DeathPhosphoSitePlus
S376SPSQSsMVARTIRAK4HPRD; phosphoELM; RegPhos
S376SPSQSsMVARTIRAK1HPRD; RegPhos
S371RFAGSsPSQSSPkinasePhosphoSitePlus
T100ARDIItAWHPPAKT_groupRegPhos
T387QTVRGtLAYLPIRAK1HPRD; phosphoELM; RegPhos
T387QTVRGtLAYLPIRAK4HPRD; phosphoELM; RegPhos
T66RSGQRtASVLWAKT1HPRD; RegPhos
S601SAALRsWHLTPPhosphoSitePlus
T209EISRGtHNFSEPhosphoSitePlus
S373AGSSPsQSSMVPkinasePhosphoSitePlus
Y515PMTQVyERLEKPkinasePhosphoSitePlus
T100ARDIItAWHPPPKB_groupphosphoELM
S371RFAGSsPSQSSHPRD; phosphoELM
T209EISRGtHNFSEIRAK1phosphoELM; RegPhos
T100ARDIItAWHPPDeathPhosphoSitePlus
T66RSGQRtASVLWIRAK1HPRD; RegPhos
S131EAEAWsPRKLPPhosphoSitePlus; HPRD
S144ASTFLsPAFPGPhosphoSitePlus
S653GSSASsSSEPPPhosphoSitePlus
T100ARDIItAWHPPAKT1HPRD; RegPhos
T387QTVRGtLAYLPPkinasePhosphoSitePlus
S173WPPPPsPAPSSPhosphoSitePlus
S650LALGSsASSSSPhosphoSitePlus

Dephosphorylation site
IRAK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358997S690GGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000358997A470VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000358997V412MGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000358997C307FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000358997V412MGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000358997Q421HGreenman2007, HPIBreast Cancer15908952, 17344846, 18428421

Differential expressed protein
IRAK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IRAK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IRAK4_HUMANIRAK1_HUMANkinase -> substrateRegPhos
AKT1_HUMANIRAK1_HUMANkinase -> substrateRegPhos
IRAK1_HUMANSTAT3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LCK_HUMANIRAK1_HUMANkinase -> substrateRobert H Newman (2013)
IRAK1_HUMANIRAK1_HUMANkinase -> substrateRegPhos
IRAK1_HUMANSNF5_HUMANkinase -> substrateRobert H Newman (2013)
IRAK1_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANIRAK1_HUMANkinase -> substrateRegPhos
IRAK1_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
IRAK1_HUMANIRF7_HUMANkinase -> substrateKEGG
IRAK1_HUMANCSK22_HUMANkinase -> substrateRobert H Newman (2013)
IRAK1_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
MYD88_HUMANIRAK1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04620Toll-like receptor signaling pathway
hsa04210Apoptosis
hsa05162Measles
hsa05133Pertussis
hsa04722Neurotrophin signaling pathway
hsa05152Tuberculosis
hsa05140Leishmaniasis
hsa05169Epstein-Barr virus infection
hsa04064NF-kappa B signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0004704NF-kappaB-inducing kinase activityTASmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0032494response to peptidoglycanIEAbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0046777protein autophosphorylationIDAbiological_process
GO:0070498interleukin-1-mediated signaling pathwayIEAbiological_process
GO:0005811lipid particleISScellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0032496response to lipopolysaccharideIMPbiological_process
GO:0007165signal transductionNASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0046777protein autophosphorylationIEAbiological_process
GO:0051259protein oligomerizationIMPbiological_process
GO:0007250activation of NF-kappaB-inducing kinase activityIDAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0016301kinase activityIDAmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cTASbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0034134toll-like receptor 2 signaling pathwayIEAbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0001959regulation of cytokine-mediated signaling pathwayIMPbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0032088negative regulation of NF-kappaB transcription facIMPbiological_process
GO:0007178transmembrane receptor protein serine/threonine kiNASbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0070498interleukin-1-mediated signaling pathwayIMPbiological_process
GO:0045323interleukin-1 receptor complexNAScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0016567protein ubiquitinationTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0005149interleukin-1 receptor bindingIEAmolecular_function
GO:0031663lipopolysaccharide-mediated signaling pathwayIMPbiological_process
GO:0004674protein serine/threonine kinase activityNASmolecular_function
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayIMPbiological_process
GO:0070555response to interleukin-1IMPbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071456cellular response to hypoxiaIEAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0004842ubiquitin-protein ligase activityTASmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0008063Toll signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process