Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SNF5_HUMAN
Description:SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 [Source:HGNC Symbol;Acc:11103]
Location:chr22 q11.23
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S49YKRYPsLWRRLPhosphoSitePlus
S120KAKRNsQWVPTHPRD
T372DQDRNtRRMRRSNF5PhosphoSitePlus
T134SQWVPtLPNSSPhosphoSitePlus
S129KAKRNsQWVPTPhosphoSitePlus; HPRD; phosphoELM
S7MMMALsKTFGQPhosphoSitePlus
T150VPCSTtINRNRSNF5PhosphoSitePlus

Dephosphorylation site
SNF5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263121R242KCOSMICMelanoma
ENSP00000263121P173SCOSMICNeoplasms by Histologic Type11921280
ENSP00000263121R377fs*10COSMICCentral Nervous System Neoplasms17152049
ENSP00000263121R201*COSMICCentral Nervous System Neoplasms10556283
ENSP00000263121R53*COSMICNeoplasms by Histologic Type21061303
ENSP00000263121Q368*COSMICLymphoma11104031
ENSP00000263121P48SCOSMICNeoplasms by Histologic Type10556283
ENSP00000263121E306*COSMICCentral Nervous System Neoplasms12429635
ENSP00000263121Y47*COSMICCentral Nervous System Neoplasms10556283
ENSP00000263121E280*COSMICNeoplasms by Histologic Type10556283
ENSP00000263121I112fs*31COSMICNeoplasms by Histologic Type17152049
ENSP00000263121P290fs*6COSMICNeoplasms by Histologic Type12429635
ENSP00000263121R158*COSMICCentral Nervous System Neoplasms10556283
ENSP00000263121G317fs*3COSMICNeoplasms by Histologic Type9671307
ENSP00000263121R341LCOSMICLymphoma11104031
ENSP00000263121A109TCOSMICSkin Cancer21984974
ENSP00000263121Q257*COSMICSarcoma19683621
ENSP00000263121Y326*COSMICCentral Nervous System Neoplasms17152049
ENSP00000263121P117fs*26COSMICNeoplasms by Histologic Type12429635
ENSP00000263121W206*COSMICCentral Nervous System Neoplasms10556283
ENSP00000263121P188LCOSMICMelanoma21499247
ENSP00000263121P116TCOSMICPancreatic Cancer17040295
ENSP00000263121E216*COSMICNeoplasms by Histologic Type10602515
ENSP00000263121V262ICOSMICOvarian Cancer21720365
ENSP00000263121L142*COSMICCentral Nervous System Neoplasms19276269
ENSP00000263121T118fs*25COSMICNeoplasms by Histologic Type10556283
ENSP00000263121P383fs*3COSMICCentral Nervous System Neoplasms10914721
ENSP00000263121R377HCOSMICBrain Cancer11161377
ENSP00000263121R127GCOSMICCentral Nervous System Neoplasms10556283
ENSP00000263121W51*COSMICCentral Nervous System Neoplasms10556283
ENSP00000263121A327TCOSMICLung Cancer20668451
ENSP00000263121N152DCOSMICLymphoma12684622
ENSP00000383984P342STCGAOvarian Cancer21720365, 18772890
ENSP00000263121I237fs*30COSMICCentral Nervous System Neoplasms19276269
ENSP00000263121Q182fs*27COSMICCentral Nervous System Neoplasms10556283
ENSP00000263121K265*COSMICCentral Nervous System Neoplasms12429635
ENSP00000383984Q359RTCGAOvarian Cancer21720365, 18772890
ENSP00000263121R374QCOSMICLymphoma11104031
ENSP00000263121R40*COSMICNeoplasms by Histologic Type10602515
ENSP00000263121Q260*COSMICCentral Nervous System Neoplasms9892189
ENSP00000263121P183LCOSMICMelanoma21499247
ENSP00000263121Q368RCOSMICOvarian Cancer21720365
ENSP00000263121S284LCOSMICNeoplasms by Histologic Type10556283
ENSP00000263121Q243*COSMICNeoplasms by Histologic Type9892189
ENSP00000263121A144fs*32COSMICCentral Nervous System Neoplasms17152049
ENSP00000263121P351SCOSMICOvarian Cancer21720365
ENSP00000263121R40fs*15COSMICCentral Nervous System Neoplasms15779233
ENSP00000263121A203TCOSMICLymphoma11104031
ENSP00000263121W281*COSMICNeoplasms by Histologic Type12429635
ENSP00000263121A382fs*4COSMICCentral Nervous System Neoplasms12429635
ENSP00000263121K211*COSMICNeoplasms by Histologic Type10556283
ENSP00000263121S49*COSMICCentral Nervous System Neoplasms12429635

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000263121Uterine CancerTreatment(none vs. transfected with the pOP13 vector that containing E7)cell lineDown14997504

Hyperphosphorylation site
SNF5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IRAK1_HUMANSNF5_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SNF5_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071564npBAF complexISScellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0007049cell cycleIEAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0071564npBAF complexIEAcellular_component
GO:0003713transcription coactivator activityIMPmolecular_function
GO:0030957Tat protein bindingIPImolecular_function
GO:0015074DNA integrationTASbiological_process
GO:0000228nuclear chromosomeIEAcellular_component
GO:0016514SWI/SNF complexIDAcellular_component
GO:0043923positive regulation by host of viral transcriptionIMPbiological_process
GO:0071565nBAF complexIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0005730nucleolusIDAcellular_component
GO:0001824blastocyst developmentIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006337nucleosome disassemblyIDAbiological_process
GO:0045090retroviral genome replicationIDAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0016514SWI/SNF complexIEAcellular_component
GO:0006338chromatin remodelingIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0001835blastocyst hatchingIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0016585chromatin remodeling complexIEAcellular_component
GO:0071565nBAF complexISScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0001741XY bodyIEAcellular_component
GO:0006357regulation of transcription from RNA polymerase IINASbiological_process
GO:0002039p53 bindingIPImolecular_function


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