Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ILK_HUMAN
Description:integrin-linked kinase [Source:HGNC Symbol;Acc:6040]
Location:chr11 p15.4
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S343ADVKFsFQCPGPkinase_TyrPhosphoSitePlus
T181RPRNGtLNKHSPhosphoSitePlus
T172TFWKGtTRTRPPhosphoSitePlus
S246RLRIFsHPNVLPkinase_TyrPhosphoSitePlus
S186TLNKHsGIDFKPhosphoSitePlus
T173FWKGTtRTRPRPhosphoSitePlus
S343ADVKFsFQCPGILKHPRD; phosphoELM; RegPhos

Dephosphorylation site
ILK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000403487D138GTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000299421A405VCOSMICGastric Cancer21097718
ENSP00000299421D138GTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000379975D138GTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000379975Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
ILK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ILK_HUMANAKT3_HUMANkinase -> substrateKEGG
ILK_HUMANMYPT1_HUMANkinase -> substrateHPRD; RegPhos
ILK_HUMANPDPK1_HUMANkinase -> substrateRobert H Newman (2013)
ILK_HUMANPP14A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ILK_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
ILK_HUMANILK_HUMANkinase -> substrateHPRD; RegPhos
ILK_HUMANIF4A2_HUMANkinase -> substrateRobert H Newman (2013)
ILK_HUMANNACA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ILK_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)
ILK_HUMANPP14B_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ILK_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
ILK_HUMANDDX20_HUMANkinase -> substrateRobert H Newman (2013)
ILK_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
ILK_HUMANGSK3B_HUMANkinase -> substrateNetPath
ILK_HUMANPP14C_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ILK_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
ILK_HUMANAKT1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
PI3R5_HUMANILK_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05213Endometrial cancer
hsa04510Focal adhesion
hsa03320PPAR signaling pathway
hsa05100Bacterial invasion of epithelial cells

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042327positive regulation of phosphorylationIMPbiological_process
GO:0050775positive regulation of dendrite morphogenesisIEAbiological_process
GO:0001954positive regulation of cell-matrix adhesionIEAbiological_process
GO:0045197establishment or maintenance of epithelial cell apIEAbiological_process
GO:0014912negative regulation of smooth muscle cell migratioIEAbiological_process
GO:0045773positive regulation of axon extensionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045663positive regulation of myoblast differentiationIEAbiological_process
GO:0030027lamellipodiumIEAcellular_component
GO:0004871signal transducer activityIEAmolecular_function
GO:0034446substrate adhesion-dependent cell spreadingIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0009966regulation of signal transductionIEAbiological_process
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0048812neuron projection morphogenesisIEAbiological_process
GO:0007160cell-matrix adhesionNASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0018105peptidyl-serine phosphorylationIEAbiological_process
GO:0043206extracellular fibril organizationIEAbiological_process
GO:0008283cell proliferationNASbiological_process
GO:0005178integrin bindingIEAmolecular_function
GO:0050772positive regulation of axonogenesisIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0007050cell cycle arrestIEAbiological_process
GO:0005911cell-cell junctionIEAcellular_component
GO:0010667negative regulation of cardiac muscle cell apoptotIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0030017sarcomereIEAcellular_component
GO:0019901protein kinase bindingIPImolecular_function
GO:0043198dendritic shaftIEAcellular_component
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0030424axonIEAcellular_component
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0043195terminal buttonIEAcellular_component
GO:0005737cytoplasmNAScellular_component
GO:0034329cell junction assemblyTASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0090263positive regulation of canonical Wnt receptor signIMPbiological_process
GO:0030513positive regulation of BMP signaling pathwayIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0001558regulation of cell growthIEAbiological_process
GO:0032288myelin assemblyIEAbiological_process
GO:0007569cell agingIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0048662negative regulation of smooth muscle cell proliferIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0032956regulation of actin cytoskeleton organizationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0045669positive regulation of osteoblast differentiationIEAbiological_process
GO:0051897positive regulation of protein kinase B signaling IEAbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0006469negative regulation of protein kinase activityIEAbiological_process
GO:0005925focal adhesionIEAcellular_component
GO:0043406positive regulation of MAP kinase activityIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043034costamereIEAcellular_component