Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITA2B_HUMAN
Description:integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) [Source:HGNC Symbol;Acc:6138]
Location:chr17 q21.31
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y479NQVAVyRAQPVFG-GAPPhosphoSitePlus
Y344VGAPLyMESRAFG-GAPPhosphoSitePlus
Y384TGTQLyGRFGSPhosphoSitePlus
Y197SWDKRyCEAGFPhosphoSitePlus
S60DFHKDsHGRVAPhosphoSitePlus
Y319EQMASyFGHSVPhosphoSitePlus
Y360EVGRVyLFLQPFG-GAPPhosphoSitePlus

Dephosphorylation site
ITA2B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262407S415ICOSMICLung Cancer
ENSP00000262407R889LCOSMICOvarian Cancer21720365
ENSP00000262407G472RCOSMICOvarian Cancer21720365

Differential expressed protein
ITA2B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ITA2B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
Q15552_HUMANITA2B_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANITA2B_HUMANTF -> target geneTRANSFAC
GATA1_HUMANITA2B_HUMANTF -> target geneTRANSFAC
SPI1_HUMANITA2B_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ITA2B_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007155cell adhesionTASbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0031092platelet alpha granule membraneTAScellular_component
GO:0005925focal adhesionIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0050840extracellular matrix bindingIEAmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0008305integrin complexIEAcellular_component


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