| UniProt/SwissProt ID: | ITA2B_HUMAN |
| Description: | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) [Source:HGNC Symbol;Acc:6138] |
| Location: | chr17 q21.31 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y479 | NQVAVyRAQPV | FG-GAP | PhosphoSitePlus |
| Y344 | VGAPLyMESRA | FG-GAP | PhosphoSitePlus |
| Y384 | TGTQLyGRFGS | PhosphoSitePlus | |
| Y197 | SWDKRyCEAGF | PhosphoSitePlus | |
| S60 | DFHKDsHGRVA | PhosphoSitePlus | |
| Y319 | EQMASyFGHSV | PhosphoSitePlus | |
| Y360 | EVGRVyLFLQP | FG-GAP | PhosphoSitePlus |
| Dephosphorylation site |
| ITA2B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000262407 | S415I | COSMIC | Lung Cancer | ENSP00000262407 | R889L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000262407 | G472R | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| ITA2B_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ITA2B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| Q15552_HUMAN | ITA2B_HUMAN | TF -> target gene | TRANSFAC |
| HNF1A_HUMAN | ITA2B_HUMAN | TF -> target gene | TRANSFAC |
| GATA1_HUMAN | ITA2B_HUMAN | TF -> target gene | TRANSFAC |
| SPI1_HUMAN | ITA2B_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ITA2B_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0002576 | platelet degranulation | TAS | biological_process |
| GO:0031092 | platelet alpha granule membrane | TAS | cellular_component |
| GO:0005925 | focal adhesion | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0050840 | extracellular matrix binding | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007160 | cell-matrix adhesion | IEA | biological_process |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0007229 | integrin-mediated signaling pathway | IEA | biological_process |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0008305 | integrin complex | IEA | cellular_component |