Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HCK_HUMAN
Description:hemopoietic cell kinase [Source:HGNC Symbol;Acc:4840]
Location:chr20 q11.21
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y330TKEPIyIITEFPkinase_TyrPhosphoSitePlus
Y209DNGGFyISPRSHCKphosphoELM; RegPhos
Y127TRKEGyIPSNYSH3_1PhosphoSitePlus
S238LCQKLsVPCMSPhosphoSitePlus
T412EDNEYtAREGAPkinase_TyrPhosphoSitePlus
T202HYKIRtLDNGGSH2PhosphoSitePlus
Y522ATESQyQQHCKphosphoELM
Y180TTKGSySLSVRSH2PhosphoSitePlus
Y411IEDNEyTAREGHCKHPRD; phosphoELM; RegPhos; SysPTM
S119WWKARsLATRKSH3_1PhosphoSitePlus
Y522ATESQyQQQPCSKRegPhos
Y411IEDNEyTAREGPkinase_TyrPhosphoSitePlus; SysPTM
Y51PHCPVyVPDPTPhosphoSitePlus
S520YTATEsQYQQQPhosphoSitePlus
Y89VALYDyEAIHHSH3_1PhosphoSitePlus
T36QVGGNtFSKTEPhosphoSitePlus
Y51PHCPVyVPDPTHCKHPRD; RegPhos
T311ANVMKtLQHDKPkinase_TyrPhosphoSitePlus
Y522ATESQyQQCSKHPRD
S462PYPGMsNPEVIPkinase_TyrPhosphoSitePlus
Y209DNGGFyISPRSHPRD; phosphoELM
Y411IEDNEyTAREGautocatalysisRegPhos; SysPTM
Y209DNGGFyISPRSSH2PhosphoSitePlus
Y522ATESQyQQQPHCKRegPhos
Y522ATESQyQQQP_PhosphoSitePlus

Dephosphorylation site
HCK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000429848P477LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000441169P477LTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
HCK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HCK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HCK_HUMANSTA5B_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
HCK_HUMANWASP_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
HCK_HUMANDOK2_HUMANkinase -> substrateHPRD
HCK_HUMANELMO1_HUMANkinase -> substrateHPRD
HCK_HUMANHCK_HUMANkinase -> substrateRegPhos; NetPath
HCK_HUMANBCR_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
HCK_HUMANRPGF1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CSK_HUMANHCK_HUMANkinase -> substrateHPRD; RegPhos
HCK_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
HCK_HUMANCSF3R_HUMANkinase -> substrateRegPhos
HCK_HUMANADA15_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
HCK_HUMANPLCG2_HUMANkinase -> substrateRegPhos
HCK_HUMANQKI_HUMANkinase -> substrateRobert H Newman (2013)
HCK_HUMANCBL_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
HCK_HUMANPLCG1_HUMANkinase -> substrateRegPhos
HCK_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04062Chemokine signaling pathway
hsa04666Fc gamma R-mediated phagocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050764regulation of phagocytosisIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007498mesoderm developmentTASbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0018108peptidyl-tyrosine phosphorylationIMPbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:2000251positive regulation of actin cytoskeleton reorganiIMPbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0006909phagocytosisIEAbiological_process
GO:0071801regulation of podosome assemblyIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0030838positive regulation of actin filament polymerizatiTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005901caveolaIDAcellular_component
GO:0046777protein autophosphorylationIMPbiological_process
GO:0050727regulation of inflammatory responseTASbiological_process
GO:0008360regulation of cell shapeIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0005884actin filamentIDAcellular_component
GO:0045728respiratory burst after phagocytosisTASbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0004713protein tyrosine kinase activityIMPmolecular_function
GO:0006954inflammatory responseIEAbiological_process
GO:0005764lysosomeIDAcellular_component
GO:0030133transport vesicleIEAcellular_component
GO:0007229integrin-mediated signaling pathwayTASbiological_process
GO:0050690regulation of defense response to virus by virusTASbiological_process
GO:0051090regulation of sequence-specific DNA binding transcIMPbiological_process
GO:0031234extrinsic to internal side of plasma membraneIMPcellular_component
GO:0002758innate immune response-activating signal transductTASbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0042995cell projectionIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005925focal adhesionIMPcellular_component
GO:0016032viral reproductionTASbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayTASbiological_process
GO:0043299leukocyte degranulationTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0002522leukocyte migration involved in immune responseTASbiological_process
GO:0006468protein phosphorylationTASbiological_process


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