Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DYRK3_HUMAN
Description:dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 [Source:HGNC Symbol;Acc:3094]
Location:chr1 q32.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T368YQKLYtYIQSRPkinasePhosphoSitePlus
S537TIDKVsGKRVVPhosphoSitePlus
T456YCSVTtQADGRPkinasePhosphoSitePlus
T532PRPLTtIDKVSPhosphoSitePlus
Y209HLAYRyEVLKIHPRD; phosphoELM
T455RYCSVtTQADGPkinasePhosphoSitePlus
S453IPRYCsVTTQAPkinasePhosphoSitePlus
T351HGRSStKVIDFPkinasePhosphoSitePlus
Y349QKLYTyIQSRFHPRD
S469LVGGRsRRGKKPkinasePhosphoSitePlus
Y209HLAYRyEVLKIPkinasePhosphoSitePlus
Y369QKLYTyIQSRFHPRD; phosphoELM
S350HHGRSsTKVIDPkinasePhosphoSitePlus
Y189HLAYRyEVLKIHPRD
S372YTYIQsRFYRAPkinasePhosphoSitePlus
Y369QKLYTyIQSRFPkinasePhosphoSitePlus
Y367EYQKLyTYIQSPkinasePhosphoSitePlus

Dephosphorylation site
DYRK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356076T34ACOSMICGastric Cancer21097718
ENSP00000356076R313CCOSMICGastric Cancer21097718
ENSP00000356073R205KBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000356073R225KBIOMARTNeoplasms by Histologic Type21930507, 21930502

Differential expressed protein
DYRK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DYRK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DYRK3_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANSMBT1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANCREB1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANSPF45_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANGRHL1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANTE2IP_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANLRIG1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK3_HUMANXPA_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
DYRK3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004672protein kinase activityIDAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0030218erythrocyte differentiationIEAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0004712protein serine/threonine/tyrosine kinase activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0030218erythrocyte differentiationIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process


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