Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADA1B_HUMAN
Description:adrenoceptor alpha 1B [Source:HGNC Symbol;Acc:278]
Location:chr5 q33.3
Node attribute:receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S410DSLDDsGSCLSPRKCAHPRD
T264NFHEDtLSSTKRegPhos
S396WTRGGsLERSQPKCaRegPhos
Y144ISIDRyIGVRY7tm_1PhosphoSitePlus
S402LERSQsRKDSLPKCaRegPhos
S396WTRGGsLERSQPRKCAHPRD
S410DSLDDsGSCLSPKCaRegPhos
S402LERSQsRKDSLPRKCAHPRD
S417SCLSGsQRTLPPhosphoSitePlus
Y153RYSLQyPTLVT7tm_1PhosphoSitePlus
S267EDTLSsTKAKGRegPhos
S410DSLDDsGSCLSPhosphoSitePlus
Y149YIGVRySLQYP7tm_1PhosphoSitePlus
S406QSRKDsLDDSGPRKCAHPRD
S412LDDSGsCLSGSPRKCAHPRD
S406QSRKDsLDDSGPKCaRegPhos
S412LDDSGsCLSGSPKCaRegPhos
S412LDDSGsCLSGSPhosphoSitePlus

Dephosphorylation site
ADA1B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000306662L20FCOSMICLung Cancer20668451

Differential expressed protein
ADA1B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADA1B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DOPO_HUMANADA1B_HUMANligand -> receptorHPMR
KPCA_HUMANADA1B_HUMANkinase -> substrateHPRD
ZAGL2_HUMANADA1B_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04970Salivary secretion
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04270Vascular smooth muscle contraction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005887integral to plasma membraneTAScellular_component
GO:0005634nucleusIDAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0001987vasoconstriction of artery involved in baroreceptoIEAbiological_process
GO:0007626locomotory behaviorIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0042593glucose homeostasisIEAbiological_process
GO:0001996positive regulation of heart rate by epinephrine-nIEAbiological_process
GO:0007512adult heart developmentIEAbiological_process
GO:0035265organ growthIEAbiological_process
GO:0048148behavioral response to cocaineIEAbiological_process
GO:0031965nuclear membraneIDAcellular_component
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007275multicellular organismal developmentTASbiological_process
GO:0043410positive regulation of MAPK cascadeIDAbiological_process
GO:0001997positive regulation of the force of heart contractIEAbiological_process
GO:0045818negative regulation of glycogen catabolic processIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0043278response to morphineIEAbiological_process
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0007243intracellular protein kinase cascadeTASbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recTASbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0008542visual learningIEAbiological_process
GO:0001974blood vessel remodelingIEAbiological_process
GO:0045819positive regulation of glycogen catabolic processIEAbiological_process
GO:0016049cell growthIEAbiological_process
GO:0004937alpha1-adrenergic receptor activityIEAmolecular_function


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