Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDC42_HUMAN
Description:cell division cycle 42 [Source:HGNC Symbol;Acc:1736]
Location:chr1 p36.12
Node attribute:PPI(source); PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T141PITPEtAEKLARas; ORC3_NPhosphoSitePlus
Y32KFPSEyVPTVFRasPhosphoSitePlus
Y64AGQEDyDRLRPSRCphosphoELM
Y64AGQEDyDRLRPRasPhosphoSitePlus
Y64AGQEDyDRLRPSrcRegPhos
S30TNKFPsEYVPTRasPhosphoSitePlus

Dephosphorylation site
CDC42_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000383118S30LCOSMICLymphoma19657110
ENSP00000341072S30LCOSMICLymphoma19657110

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000314458Gastric CancerMetastasiscell lineDown0.6717022644
ENSP00000314458Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineDown0.5616319398
ENSP00000314458Gastric CancerMetastasiscell lineDown0.6717022644

Hyperphosphorylation site
CDC42_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANCDC42_HUMANotherKEGG
CDC42_HUMANACTG_HUMANotherKEGG
CDC42_HUMANDIAP3_HUMANotherKEGG
CDC42_HUMANMK14_HUMANotherKEGG
CDC42_HUMANPAR6A_HUMANotherKEGG
CDC42_HUMANRAC1_HUMANotherKEGG
CDC42_HUMANCDC42_HUMANotherKEGG
RAC1_HUMANCDC42_HUMANotherKEGG
FGD1_HUMANCDC42_HUMANotherKEGG
CDC42_HUMANM3K1_HUMANotherKEGG
CDC42_HUMANWASP_HUMANotherKEGG
VGFR2_HUMANCDC42_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa05211Renal cell carcinoma
hsa04144Endocytosis
hsa04370VEGF signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04666Fc gamma R-mediated phagocytosis
hsa04520Adherens junction
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa04912GnRH signaling pathway
hsa05203Viral carcinogenesis
hsa05100Bacterial invasion of epithelial cells
hsa04660T cell receptor signaling pathway
hsa05212Pancreatic cancer
hsa04010MAPK signaling pathway
hsa05130Pathogenic Escherichia coli infection
hsa04360Axon guidance
hsa05132Salmonella infection
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa05200Pathways in cancer
hsa04722Neurotrophin signaling pathway
hsa05131Shigellosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003924GTPase activityTASmolecular_function
GO:0046847filopodium assemblyIEAbiological_process
GO:0007097nuclear migrationIEAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0042692muscle cell differentiationTASbiological_process
GO:0043005neuron projectionIDAcellular_component
GO:0016020membraneIEAcellular_component
GO:0002040sprouting angiogenesisIEAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0031069hair follicle morphogenesisIEAbiological_process
GO:0090135actin filament branchingIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0043497regulation of protein heterodimerization activityIEAbiological_process
GO:0051835positive regulation of synapse structural plasticiIEAbiological_process
GO:0006184GTP catabolic processTASbiological_process
GO:0042059negative regulation of epidermal growth factor recTASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0045177apical part of cellIEAcellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0003161cardiac conduction system developmentIEAbiological_process
GO:0090316positive regulation of intracellular protein transIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0007088regulation of mitosisIEAbiological_process
GO:0042995cell projectionIEAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0045740positive regulation of DNA replicationIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0000139Golgi membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005622intracellularIEAcellular_component
GO:0043552positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0034332adherens junction organizationIEAbiological_process
GO:0045859regulation of protein kinase activityIEAbiological_process
GO:0090136epithelial cell-cell adhesionIEAbiological_process
GO:0031274positive regulation of pseudopodium assemblyIDAbiological_process
GO:0051988regulation of attachment of spindle microtubules tIMPbiological_process
GO:0051647nucleus localizationIEAbiological_process
GO:0007163establishment or maintenance of cell polarityTASbiological_process
GO:0030175filopodiumIDAcellular_component
GO:0048554positive regulation of metalloenzyme activityIEAbiological_process
GO:0030742GTP-dependent protein bindingIEAmolecular_function
GO:0051149positive regulation of muscle cell differentiationTASbiological_process
GO:0051683establishment of Golgi localizationIEAbiological_process
GO:0003334keratinocyte developmentIEAbiological_process
GO:0034613cellular protein localizationIEAbiological_process
GO:0031424keratinizationIEAbiological_process
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0042176regulation of protein catabolic processIEAbiological_process
GO:0031333negative regulation of protein complex assemblyIPIbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0060684epithelial-mesenchymal cell signalingIEAbiological_process
GO:0043025neuronal cell bodyIDAcellular_component
GO:0031647regulation of protein stabilityIEAbiological_process
GO:0030225macrophage differentiationTASbiological_process
GO:0030036actin cytoskeleton organizationIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0060047heart contractionIEAbiological_process
GO:0071338positive regulation of hair follicle cell proliferIEAbiological_process
GO:0031435mitogen-activated protein kinase kinase kinase binIEAmolecular_function
GO:0072686mitotic spindleIDAcellular_component
GO:0051489regulation of filopodium assemblyIDAbiological_process
GO:0071944cell peripheryIEAcellular_component
GO:0005815microtubule organizing centerIEAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0046330positive regulation of JNK cascadeIEAbiological_process
GO:0060789hair follicle placode formationIEAbiological_process
GO:0072384organelle transport along microtubuleIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0015031protein transportIEAbiological_process
GO:0051246regulation of protein metabolic processIEAbiological_process
GO:0035264multicellular organism growthIEAbiological_process
GO:0051017actin filament bundle assemblyIEAbiological_process
GO:0060661submandibular salivary gland formationIEAbiological_process
GO:0030496midbodyIDAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0051233spindle midzoneIDAcellular_component
GO:0035088establishment or maintenance of apical/basal cell IEAbiological_process
GO:0071777positive regulation of cell cycle cytokinesisIMPbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0048730epidermis morphogenesisIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0007015actin filament organizationIEAbiological_process
GO:0030141secretory granuleIEAcellular_component
GO:0034191apolipoprotein A-I receptor bindingIPImolecular_function
GO:0031996thioesterase bindingIPImolecular_function
GO:0019901protein kinase bindingIDAmolecular_function
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0048664neuron fate determinationIEAbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIEAbiological_process
GO:0007030Golgi organizationIEAbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0005829cytosolTAScellular_component