Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FGD1_HUMAN
Description:FYVE, RhoGEF and PH domain containing 1 [Source:HGNC Symbol;Acc:3663]
Location:chrX p11.22
Node attribute:PPI(target); PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S365MERQEsVELTVCenp-B_dimerisPhosphoSitePlus
T711REDEDtPPNSPzf-DHHCPhosphoSitePlus
S208EASPSsAAVSSPhosphoSitePlus
T711REDEDtPPNSPHPRD; phosphoELM
S48LARRGsGSALGPhosphoSitePlus; HPRD; phosphoELM
S715DTPPNsPNVDLHPRD; phosphoELM
T704KLLNStNREDEzf-DHHCPhosphoSitePlus
S114RILVKsLSLDPPhosphoSitePlus
S205PRAEAsPSSAAPhosphoSitePlus; HPRD; phosphoELM
S50RRGSGsALGGPHPRD; phosphoELM
T704KLLNStNREDEHPRD; phosphoELM
S558TAAEHsNAAIRRhoGEFPhosphoSitePlus
T553LELIAtAAEHSRhoGEFPhosphoSitePlus
S116LVKSLsLDPGQPhosphoSitePlus; HPRD; phosphoELM
S649MELKEsSNLNLHPRD
S212SSAAVsSLIEKPhosphoSitePlus
S715DTPPNsPNVDLzf-DHHCPhosphoSitePlus

Dephosphorylation site
FGD1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000364277V852MCOSMICCentral Nervous System Neoplasms18772396
ENSP00000364277D617NCOSMICOvarian Cancer21720365
ENSP00000364277A818SCOSMICOvarian Cancer21720365
ENSP00000364277R563CCOSMICHead and Neck Cancer21984974
ENSP00000364277R636WCOSMICMelanoma20016485
ENSP00000364277S309RBIOMARTBreast Cancer21930507, 21930502
ENSP00000364277E594QBIOMARTBreast Cancer21930507, 21930502
ENSP00000364277L908VCOSMICOvarian Cancer21720365

Differential expressed protein
FGD1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FGD1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG12_HUMANFGD1_HUMANotherKEGG
FGD1_HUMANCDC42_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0007010cytoskeleton organizationISSbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0001726ruffleISScellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0001726ruffleIEAcellular_component
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0030036actin cytoskeleton organizationIDAbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0046847filopodium assemblyIDAbiological_process
GO:0005085guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0008360regulation of cell shapeISSbiological_process
GO:0008360regulation of cell shapeIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0031267small GTPase bindingIDAmolecular_function
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0043088regulation of Cdc42 GTPase activityIDAbiological_process
GO:0009887organ morphogenesisTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0007275multicellular organismal developmentTASbiological_process
GO:0005794Golgi apparatusISScellular_component
GO:0005737cytoplasmISScellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0030027lamellipodiumISScellular_component
GO:0007010cytoskeleton organizationIEAbiological_process
GO:0030027lamellipodiumIEAcellular_component


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