| UniProt/SwissProt ID: | GDF9_HUMAN |
| Description: | growth differentiation factor 9 [Source:HGNC Symbol;Acc:4224] |
| Location: | chr5 q31.1 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y394 | AVGHRyGSPVH | TGF_beta | PhosphoSitePlus |
| S186 | KEPKSsSRTLG | PhosphoSitePlus | |
| S288 | YKRRPsQGPDQ | PhosphoSitePlus | |
| S325 | GQETVsSELKK | PhosphoSitePlus | |
| T189 | KSSSRtLGRAP | PhosphoSitePlus | |
| S156 | EHLLKsVLLYN | PhosphoSitePlus | |
| S170 | SVSFSsAVKCV | PhosphoSitePlus | |
| Y407 | VQNIIyEKLDS | TGF_beta | PhosphoSitePlus |
| S196 | GRAPYsFTFNS | PhosphoSitePlus | |
| S185 | IKEPKsSSRTL | PhosphoSitePlus | |
| Dephosphorylation site |
| GDF9_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000367942 | L62I | COSMIC | Skin Cancer | 21984974 | ENSP00000296875 | A64T | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000296875 | S280C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000367942 | E341K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000296875 | P247R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000367942 | S280C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000296875 | P127S | COSMIC | Melanoma | 21499247 | ENSP00000296875 | E341K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000367942 | P247R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000367942 | A64T | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000367942 | P127S | COSMIC | Melanoma | 21499247 | ENSP00000296875 | L62I | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| GDF9_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GDF9_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GDF9_HUMAN | BMPR2_HUMAN | ligand -> receptor | HPMR |
| GDF9_HUMAN | TGFR1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| GDF9_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008284 | positive regulation of cell proliferation | IDA | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0007292 | female gamete generation | TAS | biological_process |
| GO:0001555 | oocyte growth | IEA | biological_process |
| GO:0005125 | cytokine activity | IEA | molecular_function |
| GO:0007179 | transforming growth factor beta receptor signaling | TAS | biological_process |
| GO:0008083 | growth factor activity | IEA | molecular_function |
| GO:2000870 | regulation of progesterone secretion | IDA | biological_process |
| GO:0030308 | negative regulation of cell growth | IEA | biological_process |