Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GDF9_HUMAN
Description:growth differentiation factor 9 [Source:HGNC Symbol;Acc:4224]
Location:chr5 q31.1
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y394AVGHRyGSPVHTGF_betaPhosphoSitePlus
S186KEPKSsSRTLGPhosphoSitePlus
S288YKRRPsQGPDQPhosphoSitePlus
S325GQETVsSELKKPhosphoSitePlus
T189KSSSRtLGRAPPhosphoSitePlus
S156EHLLKsVLLYNPhosphoSitePlus
S170SVSFSsAVKCVPhosphoSitePlus
Y407VQNIIyEKLDSTGF_betaPhosphoSitePlus
S196GRAPYsFTFNSPhosphoSitePlus
S185IKEPKsSSRTLPhosphoSitePlus

Dephosphorylation site
GDF9_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000367942L62ICOSMICSkin Cancer21984974
ENSP00000296875A64TCOSMICHead and Neck Cancer21798893
ENSP00000296875S280CCOSMICHead and Neck Cancer21798893
ENSP00000367942E341KBIOMARTBreast Cancer21930507, 21930502
ENSP00000296875P247RBIOMARTBreast Cancer21930507, 21930502
ENSP00000367942S280CCOSMICHead and Neck Cancer21798893
ENSP00000296875P127SCOSMICMelanoma21499247
ENSP00000296875E341KBIOMARTBreast Cancer21930507, 21930502
ENSP00000367942P247RBIOMARTBreast Cancer21930507, 21930502
ENSP00000367942A64TCOSMICHead and Neck Cancer21798893
ENSP00000367942P127SCOSMICMelanoma21499247
ENSP00000296875L62ICOSMICSkin Cancer21984974

Differential expressed protein
GDF9_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GDF9_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GDF9_HUMANBMPR2_HUMANligand -> receptorHPMR
GDF9_HUMANTGFR1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
GDF9_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0007292female gamete generationTASbiological_process
GO:0001555oocyte growthIEAbiological_process
GO:0005125cytokine activityIEAmolecular_function
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:2000870regulation of progesterone secretionIDAbiological_process
GO:0030308negative regulation of cell growthIEAbiological_process


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