Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:APOE_HUMAN
Description:apolipoprotein E [Source:HGNC Symbol;Acc:613]
Location:chr19 q13.32
Node attribute:phosphotase; ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S314AAPVPsDNH__PhosphoSitePlus
S147AMLGQsTEELRApolipoproteinPhosphoSitePlus
T212RVRAAtVGSLAApolipoproteinPhosphoSitePlus
S147AMLGQsTEELRHPRD
S241MEEMGsRTRDRApolipoproteinPhosphoSitePlus
S241MEEMGsRTRDRHPRD
Y180KRLAVyQAGARApolipoproteinPhosphoSitePlus

Dephosphorylation site
APOE_HUMAN do not have dephosphorylation site.

Mutation site
APOE_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000252486Pancreatic CancerNormal vs. CancertissueUp2016215274
ENSP00000252486Pancreatic CancerNormal vs. CancertissueUp7.716212428
ENSP00000252486hepatitis C virusNormal vs. CancertissueUp3.816097030
ENSP00000252486Ovarian CancerNormal vs. CancertissueDown17137333
ENSP00000252486Pancreatic CancerNormal vs. CancertissueUp<215526344

Hyperphosphorylation site
APOE_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
APOE_HUMANVLDLR_HUMANligand -> receptorHPMR
APOE_HUMANLRP5_HUMANligand -> receptorHPMR
APOE_HUMANLDLR_HUMANligand -> receptorHPMR
APOE_HUMANSORL_HUMANligand -> receptorHPMR
APOE_HUMANLRP8_HUMANligand -> receptorHPMR
APOE_HUMANTAU_HUMANphosphatase -> substrateHPRD
ESR1_HUMANAPOE_HUMANTF -> target geneTRANSFAC
ZIC2_HUMANAPOE_HUMANTF -> target geneTRANSFAC
SRF_HUMANAPOE_HUMANTF -> target geneTRANSFAC
SP1_HUMANAPOE_HUMANTF -> target geneTRANSFAC
ZIC1_HUMANAPOE_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051000positive regulation of nitric-oxide synthase activIDAbiological_process
GO:0030516regulation of axon extensionTASbiological_process
GO:0006641triglyceride metabolic processIMPbiological_process
GO:0005319lipid transporter activityIDAmolecular_function
GO:0010875positive regulation of cholesterol effluxIGIbiological_process
GO:0032526response to retinoic acidIEAbiological_process
GO:0042632cholesterol homeostasisIEAbiological_process
GO:0005737cytoplasmNAScellular_component
GO:0042159lipoprotein catabolic processIEAbiological_process
GO:0042627chylomicronIDAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0046907intracellular transportTASbiological_process
GO:0016209antioxidant activityIDAmolecular_function
GO:0006898receptor-mediated endocytosisIDAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0033700phospholipid effluxIDAbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0006707cholesterol catabolic processIEAbiological_process
GO:0072358cardiovascular system developmentIEAbiological_process
GO:0051651maintenance of location in cellIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0046848hydroxyapatite bindingIEAmolecular_function
GO:0005770late endosomeIEAcellular_component
GO:0033344cholesterol effluxIEAbiological_process
GO:0014012peripheral nervous system axon regenerationIEAbiological_process
GO:0001540beta-amyloid bindingIDAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0043407negative regulation of MAP kinase activityIDAbiological_process
GO:0045773positive regulation of axon extensionIEAbiological_process
GO:0051044positive regulation of membrane protein ectodomainIDAbiological_process
GO:0008201heparin bindingIDAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0046911metal chelating activityIDAmolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0034361very-low-density lipoprotein particleIDAcellular_component
GO:0042311vasodilationIEAbiological_process
GO:0071397cellular response to cholesterolIEAbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0034374low-density lipoprotein particle remodelingIEAbiological_process
GO:0001937negative regulation of endothelial cell proliferatIDAbiological_process
GO:0006629lipid metabolic processTASbiological_process
GO:0034447very-low-density lipoprotein particle clearanceIDAbiological_process
GO:0042158lipoprotein biosynthetic processIEAbiological_process
GO:0034380high-density lipoprotein particle assemblyIDAbiological_process
GO:0048156tau protein bindingIPImolecular_function
GO:0042157lipoprotein metabolic processTASbiological_process
GO:0034384high-density lipoprotein particle clearanceIDAbiological_process
GO:0007271synaptic transmission, cholinergicTASbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0010873positive regulation of cholesterol esterificationIEAbiological_process
GO:0034364high-density lipoprotein particleIDAcellular_component
GO:0008203cholesterol metabolic processIMPbiological_process
GO:0070326very-low-density lipoprotein particle receptor binIPImolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0000302response to reactive oxygen speciesNASbiological_process
GO:0005319lipid transporter activityIEAmolecular_function
GO:0010544negative regulation of platelet activationIDAbiological_process
GO:0008289lipid bindingIDAmolecular_function
GO:0008219cell deathIEAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0005615extracellular spaceIEAcellular_component
GO:0048844artery morphogenesisIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0017127cholesterol transporter activityIEAmolecular_function
GO:0006629lipid metabolic processIEAbiological_process
GO:0071347cellular response to interleukin-1IEAbiological_process
GO:0030828positive regulation of cGMP biosynthetic processIDAbiological_process
GO:0043537negative regulation of blood vessel endothelial ceIDAbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0006917induction of apoptosisIDAbiological_process
GO:0050750low-density lipoprotein particle receptor bindingIPImolecular_function
GO:0034382chylomicron remnant clearanceIMPbiological_process
GO:0007568agingIEAbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0043691reverse cholesterol transportIDAbiological_process
GO:0060228phosphatidylcholine-sterol O-acyltransferase activIEAmolecular_function
GO:0006869lipid transportIEAbiological_process
GO:0032805positive regulation of low-density lipoprotein parIDAbiological_process
GO:0034375high-density lipoprotein particle remodelingIGIbiological_process
GO:0050728negative regulation of inflammatory responseIEAbiological_process
GO:0071813lipoprotein particle bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0034362low-density lipoprotein particleIEAcellular_component
GO:0034372very-low-density lipoprotein particle remodelingIEAbiological_process
GO:0019934cGMP-mediated signalingIDAbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0007010cytoskeleton organizationTASbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0031232extrinsic to external side of plasma membraneIEAcellular_component
GO:0042802identical protein bindingIDAmolecular_function
GO:0055088lipid homeostasisIEAbiological_process
GO:0032489regulation of Cdc42 protein signal transductionIDAbiological_process
GO:0002021response to dietary excessIEAbiological_process
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0048168regulation of neuronal synaptic plasticityTASbiological_process
GO:0042157lipoprotein metabolic processIEAbiological_process
GO:0048709oligodendrocyte differentiationIEAbiological_process
GO:0045541negative regulation of cholesterol biosynthetic prIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0030195negative regulation of blood coagulationIDAbiological_process
GO:0007263nitric oxide mediated signal transductionIDAbiological_process
GO:0034363intermediate-density lipoprotein particleIDAcellular_component
GO:0032868response to insulin stimulusIEAbiological_process