Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SORL_HUMAN
Description:sortilin-related receptor, L(DLR class) A repeats containing [Source:HGNC Symbol;Acc:11185]
Location:chr11 q24.1
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S82LRRKRsAALQPPhosphoSitePlus
Y139DVYVSyDYGKSPhosphoSitePlus
T1824SAWAKtDLGDSfn3PhosphoSitePlus
T598KSTVFtIFGSNPhosphoSitePlus
S375TNLYIsEAEGLPhosphoSitePlus
S322GSEQQsSVQLWHPRD
S329VQLWVsFGRKPHPRD
T1811KVGNLtAHTSYfn3PhosphoSitePlus
S114WAGEKsNVIVAPhosphoSitePlus; HPRD
S318VHLLGsEQQSSHPRD
S2206MITGFsDDVPMPhosphoSitePlus
Y1874VYGIFyATSFLPhosphoSitePlus
Y1719LVNTLyTVRVAfn3PhosphoSitePlus
Y136KSSDVyVSYDYPhosphoSitePlus
S2167HRRLQsSFTAFPhosphoSitePlus
S385LKFSLsLENVLPhosphoSitePlus
S499ILSKEsAPGLIPhosphoSitePlus

Dephosphorylation site
SORL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000260197L1972VHPIColorectal Cancer16959974
ENSP00000260197G622CTCGAOvarian Cancer21720365, 18772890
ENSP00000260197Y934DCOSMICHead and Neck Cancer21798893
ENSP00000260197P1213SCOSMICSkin Cancer21984974
ENSP00000260197M1581LSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000260197E348KCOSMICMelanoma21499247
ENSP00000260197V96ACOSMICSkin Cancer21984974
ENSP00000260197N466SCOSMICOvarian Cancer21720365
ENSP00000260197N466STCGAOvarian Cancer21720365, 18772890
ENSP00000260197L120SSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000260197Y728CTCGAOvarian Cancer21720365, 18772890
ENSP00000260197M1581fs*34COSMICBreast Cancer17932254
ENSP00000260197D1267NCOSMICOvarian Cancer21720365
ENSP00000260197G622*COSMICOvarian Cancer21720365
ENSP00000260197L1908VCOSMICHead and Neck Cancer21798893
ENSP00000260197Y728CCOSMICOvarian Cancer21720365
ENSP00000260197Y1136CCOSMICHepatocellular Carcinoma21822264
ENSP00000260197L1972VSjoblom2006, COSMICIntestines Cancer16959974

Differential expressed protein
SORL_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SORL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
APOE_HUMANSORL_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
SORL_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034362low-density lipoprotein particleIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0006898receptor-mediated endocytosisTASbiological_process
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006869lipid transportIEAbiological_process
GO:0004888transmembrane signaling receptor activityTASmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0030169low-density lipoprotein particle bindingIPImolecular_function


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