Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LRP5_HUMAN
Description:low density lipoprotein receptor-related protein 5 [Source:HGNC Symbol;Acc:6697]
Location:chr11 q13.2
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1593DSCPPsPATERPhosphoSitePlus
S1138LKRIEsCDLSGLdl_recept_bPhosphoSitePlus
S1589LSAEDsCPPSPPhosphoSitePlus
S1142ESCDLsGANRLLdl_recept_bPhosphoSitePlus
S1503LNPPPsPATDPPhosphoSitePlus
T185GMDGStRKIIVLdl_recept_bPhosphoSitePlus
Y1494TKATLyPPILNPhosphoSitePlus
T1492SSTKAtLYPPIPhosphoSitePlus
Y1473GGVPLyDRNHVPhosphoSitePlus
Y1552VCDSDySASRWPhosphoSitePlus

Dephosphorylation site
LRP5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000294304G106SCOSMICOvarian Cancer21720365
ENSP00000294304E1150KCOSMICSkin Cancer21984974
ENSP00000294304R353QHPIOther Cancer16252235
ENSP00000294304F295SCOSMICHead and Neck Cancer21798893
ENSP00000294304S307FHPIOther Cancer16252235
ENSP00000294304D434NHPIOther Cancer16252235
ENSP00000294304A400EHPIOther Cancer16252235
ENSP00000294304D683NHPIOther Cancer16252235
ENSP00000294304W196LCOSMICSkin Cancer21984974
ENSP00000294304R570WOMIMOther Cancer11719191
ENSP00000294304G610RHPIOther Cancer16252235 15981244
ENSP00000294304D1099YHPIOther Cancer16252235
ENSP00000294304Y733HHPIOther Cancer16252235
ENSP00000294304R1113CHPIOther Cancer16252235
ENSP00000294304E1094GCOSMICOvarian Cancer21720365
ENSP00000294304T390KHPIOther Cancer16252235
ENSP00000294304S356LHPIOther Cancer16252235 16234968
ENSP00000294304G975ACOSMICSkin Cancer21984974
ENSP00000294304D203NHPIOther Cancer16252235
ENSP00000294304R925PCOSMICLung Cancer20668451
ENSP00000294304R494QHPIOther Cancer11719191 16252235
ENSP00000294304R494QOMIMOther Cancer11719191
ENSP00000294304G404RHPIOther Cancer16252235
ENSP00000294304L458VCOSMICOvarian Cancer21720365
ENSP00000294304E460KHPIOther Cancer16252235
ENSP00000294304G520VHPIOther Cancer16252235
ENSP00000294304G1401DHPIOther Cancer16252235
ENSP00000294304W478RHPIOther Cancer16679074
ENSP00000294304S501FCOSMICMelanoma21499247
ENSP00000294304R570WHPIOther Cancer11719191 16252235 19673927
ENSP00000294304N531IHPIOther Cancer17437160
ENSP00000294304V667MOMIMOther Cancer11719191
ENSP00000294304W504CHPIOther Cancer16679074
ENSP00000294304T409AHPIOther Cancer18602879
ENSP00000294304G106STCGAOvarian Cancer21720365, 18772890
ENSP00000294304T244MHPIOther Cancer16252235 21875572
ENSP00000294304R348WHPIOther Cancer16252235

Differential expressed protein
LRP5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LRP5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SOST_HUMANLRP5_HUMANligand -> receptorHPMR
APOE_HUMANLRP5_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045840positive regulation of mitosisIDAbiological_process
GO:0060612adipose tissue developmentIMPbiological_process
GO:0042632cholesterol homeostasisIMPbiological_process
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0006897endocytosisIEAbiological_process
GO:0061304retinal blood vessel morphogenesisIMPbiological_process
GO:0060349bone morphogenesisIMPbiological_process
GO:0048539bone marrow developmentIMPbiological_process
GO:0045600positive regulation of fat cell differentiationIMPbiological_process
GO:0001702gastrulation with mouth forming secondIBAbiological_process
GO:0017147Wnt-protein bindingIBAmolecular_function
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0046849bone remodelingIBAbiological_process
GO:0030326embryonic limb morphogenesisIBAbiological_process
GO:0045668negative regulation of osteoblast differentiationIMPbiological_process
GO:0071901negative regulation of protein serine/threonine kiIMPbiological_process
GO:0016055Wnt receptor signaling pathwayIDAbiological_process
GO:0060042retina morphogenesis in camera-type eyeIMPbiological_process
GO:0044332Wnt receptor signaling pathway involved in dorsal/IDAbiological_process
GO:0008217regulation of blood pressureIMPbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0006007glucose catabolic processIMPbiological_process
GO:0043235receptor complexIDAcellular_component
GO:0060059embryonic retina morphogenesis in camera-type eyeIBAbiological_process
GO:0002076osteoblast developmentIBAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0061178regulation of insulin secretion involved in cellulIBAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0060444branching involved in mammary gland duct morphogenIBAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIDAbiological_process
GO:0060828regulation of canonical Wnt receptor signaling patIMPbiological_process
GO:0048596embryonic camera-type eye morphogenesisIBAbiological_process
GO:0015026coreceptor activityIBAmolecular_function
GO:0009952anterior/posterior pattern specificationIBAbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatIMPbiological_process


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