Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LRP8_HUMAN
Description:low density lipoprotein receptor-related protein 8, apolipoprotein e receptor [Source:HGNC Symbol;Acc:6700]
Location:chr1 p32.3
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y866FDNPVyRKTTEPhosphoSitePlus
S238DCEDRsDEAAELdl_recept_aPhosphoSitePlus

Dephosphorylation site
LRP8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000303634P631SCOSMICSkin Cancer21984974

Differential expressed protein
LRP8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LRP8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RELN_HUMANLRP8_HUMANligand -> receptorHPMR
APOE_HUMANLRP8_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
LRP8_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007596blood coagulationTASbiological_process
GO:0005901caveolaIDAcellular_component
GO:0021541ammon gyrus developmentISSbiological_process
GO:0034185apolipoprotein bindingICmolecular_function
GO:0032793positive regulation of CREB transcription factor aISSbiological_process
GO:0061003positive regulation of dendritic spine morphogenesISSbiological_process
GO:0019221cytokine-mediated signaling pathwayNASbiological_process
GO:0045860positive regulation of protein kinase activityIEAbiological_process
GO:0061098positive regulation of protein tyrosine kinase actISSbiological_process
GO:0016021integral to membraneICcellular_component
GO:0038026reelin-mediated signaling pathwayISSbiological_process
GO:0000122negative regulation of transcription from RNA polyISSbiological_process
GO:0006629lipid metabolic processNASbiological_process
GO:0038025reelin receptor activityISSmolecular_function
GO:0050731positive regulation of peptidyl-tyrosine phosphoryISSbiological_process
GO:0006508proteolysisNASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0006897endocytosisIDAbiological_process
GO:0021819layer formation in cerebral cortexIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005509calcium ion bindingIEAmolecular_function
GO:1900006positive regulation of dendrite developmentISSbiological_process
GO:0021766hippocampus developmentIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0004888transmembrane signaling receptor activityTASmolecular_function
GO:0030229very-low-density lipoprotein particle receptor actIDAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0050804regulation of synaptic transmissionISSbiological_process


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