| UniProt/SwissProt ID: | ZIC1_HUMAN |
| Description: | Zic family member 1 [Source:HGNC Symbol;Acc:12872] |
| Location: | chr3 q24 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T15 | PAIGVtTFGAS | HPRD | |
| S247 | CNKTFsTMHEL | zf-C2H2 | PhosphoSitePlus |
| T245 | KSCNKtFSTMH | zf-C2H2 | PhosphoSitePlus |
| T327 | HKRTHtGEKPF | PhosphoSitePlus | |
| T325 | KIHKRtHTGEK | zf-C2H2 | PhosphoSitePlus |
| S20 | TTFGAsRHHSA | HPRD | |
| Dephosphorylation site |
| ZIC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000282928 | K333N | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000282928 | S346G | BIOMART | Brain Cancer | 21930507, 21930502 | ENSP00000282928 | S399C | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000282928 | E337Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000282928 | Q8E | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000282928 | D4N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000282928 | S399C | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000282928 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 21 hour) | cell line | Down | 0.21 | 15169874 |
| Hyperphosphorylation site |
| ZIC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZIC1_HUMAN | APOE_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ZIC1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0008589 | regulation of smoothened signaling pathway | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0042472 | inner ear morphogenesis | ISS | biological_process |
| GO:0007610 | behavior | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | ISS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0042307 | positive regulation of protein import into nucleus | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0007389 | pattern specification process | ISS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0007417 | central nervous system development | IEA | biological_process |
| GO:0008589 | regulation of smoothened signaling pathway | ISS | biological_process |
| GO:0007389 | pattern specification process | IEA | biological_process |
| GO:0007610 | behavior | ISS | biological_process |
| GO:0042307 | positive regulation of protein import into nucleus | ISS | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | ISS | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0007420 | brain development | IDA | biological_process |
| GO:0021510 | spinal cord development | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |