Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADA2A_HUMAN
Description:adrenoceptor alpha 2A [Source:HGNC Symbol;Acc:281]
Location:chr10 q25.2
Node attribute:GPCR; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S232TRVPPsRRGPD7tm_1PhosphoSitePlus
S299EESSSsDHAERBARK1RegPhos
S346VKPGDsLPRRGHPRD
S171FPPLIsIEKKGTM; 7tm_1PhosphoSitePlus
S339GKARAsQVKPGHPRD
S313LEESSsSDHAEADRBK1HPRD
S311LDLEEsSSSDHADRBK1HPRD
S314EESSSsDHAERADRBK1HPRD
S297DLEESsSSDHA7tm_1PhosphoSitePlus
S232TRVPPsRRGPDPKC_groupphosphoELM; RegPhos
S296LDLEEsSSSDHphosphoELM; RegPhos
T136RYWSItQAIEY7tm_1PhosphoSitePlus
S298LEESSsSDHAEphosphoELM; RegPhos
S297DLEESsSSDHABARK1RegPhos
S299EESSSsDHAER7tm_1PhosphoSitePlus
S299EESSSsDHAERphosphoELM; RegPhos
S296LDLEEsSSSDHBARK1RegPhos
S297DLEESsSSDHAphosphoELM; RegPhos
S298LEESSsSDHAE7tm_1PhosphoSitePlus
S296LDLEEsSSSDH7tm_1PhosphoSitePlus
S247TRVPPsRRGPDPRKCDHPRD
S134LDRYWsITQAI7tm_1PhosphoSitePlus
S360GAAKAsRWRGR7tm_1; T2SMPhosphoSitePlus
S298LEESSsSDHAEBARK1RegPhos
S232TRVPPsRRGPDPKCdRegPhos
S312DLEESsSSDHAADRBK1HPRD
Y132ISLDRyWSITQ7tm_1PhosphoSitePlus

Dephosphorylation site
ADA2A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000280155T161MBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
ADA2A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADA2A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DOPO_HUMANADA2A_HUMANligand -> receptorHPMR
ADA2A_HUMANGNA11_HUMANGPCR -> GproteingpDB
ADA2A_HUMANGNAI1_HUMANGPCR -> GproteingpDB
ADA2A_HUMANGNAI3_HUMANGPCR -> GproteingpDB
ADA2A_HUMANGNAI2_HUMANGPCR -> GproteingpDB
ADA2A_HUMANGNAS2_HUMANGPCR -> GproteingpDB
ADA2A_HUMANGNAS1_HUMANGPCR -> GproteingpDB
ADA2A_HUMANGNAO_HUMANGPCR -> GproteingpDB
ADA2A_HUMANGNAQ_HUMANGPCR -> GproteingpDB
KPCD_HUMANADA2A_HUMANkinase -> substrateHPRD
ZAGL2_HUMANADA2A_HUMANkinase -> substrateRegPhos
ARBK1_HUMANADA2A_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016323basolateral plasma membraneTAScellular_component
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0004938alpha2-adrenergic receptor activityIDAmolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0007565female pregnancyIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0045955negative regulation of calcium ion-dependent exocyICbiological_process
GO:0043235receptor complexIDAcellular_component
GO:0030036actin cytoskeleton organizationTASbiological_process
GO:0071881adenylate cyclase-inhibiting adrenergic receptor sIDAbiological_process
GO:0007194negative regulation of adenylate cyclase activityISSbiological_process
GO:0030168platelet activationTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0071878negative regulation of adrenergic receptor signaliISSbiological_process
GO:0045955negative regulation of calcium ion-dependent exocyIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0030818negative regulation of cAMP biosynthetic processISSbiological_process
GO:0050892intestinal absorptionTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0061179negative regulation of insulin secretion involved IEAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0002526acute inflammatory responseIEAbiological_process
GO:0006928cellular component movementTASbiological_process
GO:0042593glucose homeostasisIMPbiological_process
GO:0001819positive regulation of cytokine productionIDAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0043406positive regulation of MAP kinase activityIDAbiological_process
GO:0090303positive regulation of wound healingIMPbiological_process
GO:0061179negative regulation of insulin secretion involved IMPbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0043268positive regulation of potassium ion transportISSbiological_process
GO:0046676negative regulation of insulin secretionIMPbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0031696alpha-2C adrenergic receptor bindingIPImolecular_function
GO:0007265Ras protein signal transductionTASbiological_process
GO:0006260DNA replicationIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0050796regulation of insulin secretionTASbiological_process
GO:0051926negative regulation of calcium ion transportISSbiological_process
GO:0035625epidermal growth factor-activated receptor transacIDAbiological_process
GO:0051379epinephrine bindingIDAmolecular_function
GO:0031996thioesterase bindingIPImolecular_function
GO:0032795heterotrimeric G-protein bindingIDAmolecular_function
GO:0042593glucose homeostasisIEAbiological_process
GO:1901020negative regulation of calcium ion transmembrane tISSbiological_process
GO:0007186G-protein coupled receptor signaling pathwayISSbiological_process
GO:0045741positive regulation of epidermal growth factor-actIDAbiological_process
GO:0051044positive regulation of membrane protein ectodomainIDAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0032811negative regulation of epinephrine secretionNASbiological_process
GO:0032147activation of protein kinase activityIDAbiological_process
GO:0070473negative regulation of uterine smooth muscle contrIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0032148activation of protein kinase B activityIDAbiological_process
GO:0045909positive regulation of vasodilationIEAbiological_process
GO:0071882phospholipase C-activating adrenergic receptor sigIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0051380norepinephrine bindingIDAmolecular_function
GO:0046982protein heterodimerization activityISSmolecular_function
GO:0007266Rho protein signal transductionTASbiological_process
GO:0004935adrenergic receptor activityIEAmolecular_function
GO:0031692alpha-1B adrenergic receptor bindingISSmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0071883activation of MAPK activity by adrenergic receptorIDAbiological_process
GO:0050955thermoceptionIEAbiological_process
GO:0010700negative regulation of norepinephrine secretionNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0050995negative regulation of lipid catabolic processIGIbiological_process
GO:0032870cellular response to hormone stimulusIGIbiological_process
GO:0004938alpha2-adrenergic receptor activityIEAmolecular_function
GO:0045202synapseIEAcellular_component
GO:0042596fear responseIEAbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process