Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DRD4_HUMAN
Description:dopamine receptor D4 [Source:HGNC Symbol;Acc:3025]
Location:chr11 p15.5
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S245GPGPPsPTPPA7tm_1PhosphoSitePlus
T159LLIGAtWLLSA7tm_1; TMPhosphoSitePlus
S239APRRPsGPGPP7tm_1PhosphoSitePlus
S163ATWLLsAAVAA7tm_1; TMPhosphoSitePlus

Dephosphorylation site
DRD4_HUMAN do not have dephosphorylation site.

Mutation site
DRD4_HUMAN do not have mutation site.

Differential expressed protein
DRD4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DRD4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TY3H_HUMANDRD4_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04728Dopaminergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051586positive regulation of dopamine uptake involved inICbiological_process
GO:0042053regulation of dopamine metabolic processIEAbiological_process
GO:0035176social behaviorNASbiological_process
GO:0048148behavioral response to cocaineISSbiological_process
GO:0008344adult locomotory behaviorIEAbiological_process
GO:0043195terminal buttonIEAcellular_component
GO:0033674positive regulation of kinase activityIDAbiological_process
GO:0030818negative regulation of cAMP biosynthetic processIDAbiological_process
GO:1901386negative regulation of voltage-gated calcium channIDAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0016020membraneIDAcellular_component
GO:0043197dendritic spineIEAcellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0008355olfactory learningIEAbiological_process
GO:0030424axonIEAcellular_component
GO:0001662behavioral fear responseIEAbiological_process
GO:0007212dopamine receptor signaling pathwayIEAbiological_process
GO:0042596fear responseIEAbiological_process
GO:0042053regulation of dopamine metabolic processISSbiological_process
GO:0042596fear responseISSbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0015459potassium channel regulator activityNASmolecular_function
GO:0001963synaptic transmission, dopaminergicIEAbiological_process
GO:0060080regulation of inhibitory postsynaptic membrane potISSbiological_process
GO:0017124SH3 domain bindingIDAmolecular_function
GO:0007614short-term memoryIEAbiological_process
GO:0006874cellular calcium ion homeostasisICbiological_process
GO:0046928regulation of neurotransmitter secretionIEAbiological_process
GO:0007195adenylate cyclase-inhibiting dopamine receptor sigIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0050482arachidonic acid secretionIDAbiological_process
GO:0048149behavioral response to ethanolTASbiological_process
GO:0060080regulation of inhibitory postsynaptic membrane potIEAbiological_process
GO:0008144drug bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0050848regulation of calcium-mediated signalingIEAbiological_process
GO:0001662behavioral fear responseNASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0050804regulation of synaptic transmissionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007195adenylate cyclase-inhibiting dopamine receptor sigIDAbiological_process
GO:0001591dopamine neurotransmitter receptor activity, couplISSmolecular_function
GO:0007194negative regulation of adenylate cyclase activityIDAbiological_process
GO:0001591dopamine neurotransmitter receptor activity, couplIEAmolecular_function
GO:0050709negative regulation of protein secretionIDAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0012506vesicle membraneIEAcellular_component
GO:0032417positive regulation of sodium:hydrogen antiporter IDAbiological_process
GO:0004952dopamine neurotransmitter receptor activityIDAmolecular_function
GO:0000187activation of MAPK activityIDAbiological_process
GO:0008306associative learningIEAbiological_process
GO:0048148behavioral response to cocaineIEAbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0034776response to histamineIDAbiological_process
GO:0008344adult locomotory behaviorISSbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0001975response to amphetamineISSbiological_process
GO:0005938cell cortexIEAcellular_component
GO:0035240dopamine bindingIDAmolecular_function
GO:0007212dopamine receptor signaling pathwayIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0042417dopamine metabolic processICbiological_process