| UniProt/SwissProt ID: | FAS_HUMAN |
| Description: | fatty acid synthase [Source:HGNC Symbol;Acc:3594] |
| Location: | chr17 q25.3 |
| Node attribute: | PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y2424 | AARSFyYKLRA | Thioesterase | PhosphoSitePlus |
| S2499 | ISIIHsSLAEP | HPRD | |
| Y45 | WKAGLyGLPRR | ketoacyl-synt | PhosphoSitePlus |
| T251 | ILNAGtNTDGF | HPRD | |
| T898 | SIVWKtLARAL | PhosphoSitePlus | |
| S725 | AQWHSsLARTS | HPRD | |
| T1593 | IPGKWtSQDSL | HPRD | |
| Y2433 | RAAEQyTPKAK | Thioesterase | PhosphoSitePlus |
| S2123 | YRDRDsQRDLV | HPRD; SysPTM | |
| S2198 | KADEAsELACP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y277 | LIRSLyQSAGV | Ketoacyl-synt_C | PhosphoSitePlus |
| Y2269 | LSIPTyGLQCT | Thioesterase | PhosphoSitePlus |
| T34 | GVDMVtDDDRR | ketoacyl-synt | PhosphoSitePlus |
| S1411 | PTPQDsPIFLP | PhosphoSitePlus; HPRD; phosphoELM | |
| T976 | HPESPtPNPTE | PhosphoSitePlus; HPRD; phosphoELM | |
| T217 | CKAFDtAGNGY | HPRD | |
| S1174 | IPRDPsQQELP | PhosphoSitePlus | |
| T245 | RRVYAtILNAG | HPRD | |
| T928 | TILPKtGTVSL | PhosphoSitePlus | |
| T2483 | EGDHRtLLEGS | HPRD | |
| S1479 | LSNLSsTSHVP | PhosphoSitePlus | |
| S1947 | STSNIsSLEGA | PhosphoSitePlus | |
| S361 | NLHFHsPNPEI | Ketoacyl-synt_C | PhosphoSitePlus |
| Y2425 | ARSFYyKLRAA | Thioesterase | PhosphoSitePlus |
| S1948 | TSNISsLEGAR | PhosphoSitePlus | |
| S2192 | LQELSsKADEA | PhosphoSitePlus | |
| S724 | EAQWHsSLART | HPRD | |
| S1543 | RGDLSsIRWVC | ADH_zinc_N | PhosphoSitePlus |
| S2123 | YRDRDsQRDLV | PP-binding | PhosphoSitePlus; SysPTM |
| S2236 | LMRLNsVQSSE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S2175 | LNLVLsVREVR | PP-binding | PhosphoSitePlus |
| Y1506 | LVMNVyRDGAW | PhosphoSitePlus | |
| S207 | RLGMLsPEGTC | HPRD; phosphoELM; SysPTM | |
| Y222 | TAGNGyCRSEG | ketoacyl-synt | PhosphoSitePlus |
| S1594 | PGKWTsQDSLL | HPRD | |
| Y2034 | AGQSNyGFANS | PhosphoSitePlus | |
| Y222 | TAGNGyCRSEG | HPRD | |
| Y2439 | TPKAKyHGNVM | Thioesterase | PhosphoSitePlus |
| T253 | NAGTNtDGFKE | HPRD | |
| S207 | RLGMLsPEGTC | ketoacyl-synt | PhosphoSitePlus; SysPTM |
| S2488 | TLLEGsGLESI | HPRD | |
| S1542 | TRGDLsSIRWV | ADH_zinc_N | PhosphoSitePlus |
| T1999 | PKYSGtLNLDR | PhosphoSitePlus | |
| Y1047 | AKHGLyLPTRV | PhosphoSitePlus | |
| S974 | FDHPEsPTPNP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T2204 | ELACPtPKEDG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T1273 | LSYTAtDRHPQ | PhosphoSitePlus | |
| Dephosphorylation site |
| FAS_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000304592 | A167T | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000304592 | P2357S | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000304592 | hepatitis C virus | Normal vs. Cancer | tissue | Down | 0.4 | 18715028 | ENSP00000304592 | Gastric Cancer | Metastasis | cell line | Down | 0.65 | 17022644 | ENSP00000304592 | Prostate Cancer | Treatment (none vs. bicalutamide treatment) | cell line | Up | 1.9 | 17152098 | ENSP00000304592 | Breast Cancer | Metastasis | cell line | Up | 11 | 16048908 | ENSP00000304592 | Prostate Cancer | Metastasis | tissue | Up | 2.8 | 18553995 | ENSP00000304592 | Breast Cancer | Treatment (none vs. 17b-Estradiol treatment) | cell line | Up | 2.8 | 18491314 | ENSP00000304592 | Hepatocellular Carcinoma | Metastasis | cell line | Up | 1.5 | 19016532 | ENSP00000304592 | Gastric Cancer | Metastasis | cell line | Down | 0.65 | 17022644 | ENSP00000304592 | Breast Cancer | Normal vs. Cancer | cell line | Up | 5.3 | 20198662 |
| Hyperphosphorylation site |
| FAS_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SRBP1_HUMAN | FAS_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04910 | Insulin signaling pathway |
| hsa01100 | Metabolic pathways |
| hsa00061 | Fatty acid biosynthesis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006633 | fatty acid biosynthetic process | IEA | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0004319 | enoyl-[acyl-carrier-protein] reductase (NADPH, B-s | IEA | molecular_function |
| GO:0004313 | [acyl-carrier-protein] S-acetyltransferase activit | IEA | molecular_function |
| GO:0004320 | oleoyl-[acyl-carrier-protein] hydrolase activity | IEA | molecular_function |
| GO:0047451 | 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydrata | IEA | molecular_function |
| GO:0009058 | biosynthetic process | IEA | biological_process |
| GO:0006766 | vitamin metabolic process | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0016296 | palmitoyl-[acyl-carrier-protein] hydrolase activit | IEA | molecular_function |
| GO:0004314 | [acyl-carrier-protein] S-malonyltransferase activi | IEA | molecular_function |
| GO:0004312 | fatty acid synthase activity | IEA | molecular_function |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |
| GO:0016788 | hydrolase activity, acting on ester bonds | IEA | molecular_function |
| GO:0008144 | drug binding | IEA | molecular_function |
| GO:0008152 | metabolic process | IEA | biological_process |
| GO:0016491 | oxidoreductase activity | IEA | molecular_function |
| GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process | TAS | biological_process |
| GO:0006631 | fatty acid metabolic process | TAS | biological_process |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0004316 | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) | IEA | molecular_function |
| GO:0042470 | melanosome | IEA | cellular_component |
| GO:0042802 | identical protein binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0008168 | methyltransferase activity | IEA | molecular_function |
| GO:0004317 | 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat | IEA | molecular_function |
| GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity | IEA | molecular_function |
| GO:0042587 | glycogen granule | IEA | cellular_component |
| GO:0070402 | NADPH binding | IEA | molecular_function |
| GO:0044255 | cellular lipid metabolic process | TAS | biological_process |
| GO:0004312 | fatty acid synthase activity | TAS | molecular_function |
| GO:0055114 | oxidation-reduction process | IEA | biological_process |
| GO:0016295 | myristoyl-[acyl-carrier-protein] hydrolase activit | IEA | molecular_function |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0006084 | acetyl-CoA metabolic process | IEA | biological_process |
| GO:0031325 | positive regulation of cellular metabolic process | TAS | biological_process |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0016747 | transferase activity, transferring acyl groups oth | IEA | molecular_function |
| GO:0006767 | water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0015939 | pantothenate metabolic process | TAS | biological_process |
| GO:0019432 | triglyceride biosynthetic process | TAS | biological_process |
| GO:0031177 | phosphopantetheine binding | IEA | molecular_function |