| UniProt/SwissProt ID: | KPYR_HUMAN |
| Description: | pyruvate kinase, liver and RBC [Source:HGNC Symbol;Acc:9020] |
| Location: | chr1 q22 |
| Node attribute: | PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S43 | YLRRAsVAQLT | PhosphoSitePlus | |
| S562 | GWRPGsGYTNI | PK_C | PhosphoSitePlus |
| Y564 | RPGSGyTNIMR | PK_C | PhosphoSitePlus |
| T556 | LVIVVtGWRPG | HPRD; SysPTM | |
| Y218 | VGGRIyIDDGL | PK | PhosphoSitePlus |
| S26 | RDLAKsILIGA | HPRD | |
| Y38 | GGPAGyLRRAS | PhosphoSitePlus | |
| T525 | LVIVVtGWRPG | HPRD | |
| S261 | FVRKAsDVAAV | HPRD | |
| S292 | FVRKAsDVAAV | HPRD | |
| S292 | FVRKAsDVAAV | PK | PhosphoSitePlus |
| T556 | LVIVVtGWRPG | PK_C | PhosphoSitePlus; SysPTM |
| Dephosphorylation site |
| KPYR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000339933 | R289L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000339933 | G332V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000339933 | E387K | COSMIC | Melanoma | 21499247 | ENSP00000339933 | S17F | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000339933 | G251S | COSMIC | Melanoma | 20016485 |
| Differential expressed protein |
| KPYR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KPYR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SRBP1_HUMAN | KPYR_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00620 | Pyruvate metabolism |
| hsa00230 | Purine metabolism |
| hsa01100 | Metabolic pathways |
| hsa04950 | Maturity onset diabetes of the young |
| hsa04930 | Type II diabetes mellitus |
| hsa00010 | Glycolysis / Gluconeogenesis |
| hsa04910 | Insulin signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006006 | glucose metabolic process | TAS | biological_process |
| GO:0000287 | magnesium ion binding | IEA | molecular_function |
| GO:0001666 | response to hypoxia | IEA | biological_process |
| GO:0007584 | response to nutrient | IEA | biological_process |
| GO:0033198 | response to ATP | IEA | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0014070 | response to organic cyclic compound | IEA | biological_process |
| GO:0006096 | glycolysis | IEA | biological_process |
| GO:0051707 | response to other organism | IEA | biological_process |
| GO:0051591 | response to cAMP | IEA | biological_process |
| GO:0009749 | response to glucose stimulus | IEA | biological_process |
| GO:0009408 | response to heat | IEA | biological_process |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0031325 | positive regulation of cellular metabolic process | TAS | biological_process |
| GO:0005975 | carbohydrate metabolic process | IEA | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |
| GO:0006754 | ATP biosynthetic process | IEA | biological_process |
| GO:0010038 | response to metal ion | IEA | biological_process |
| GO:0030955 | potassium ion binding | IEA | molecular_function |
| GO:0004743 | pyruvate kinase activity | IEA | molecular_function |
| GO:0010226 | response to lithium ion | IEA | biological_process |
| GO:0032869 | cellular response to insulin stimulus | IEA | biological_process |
| GO:0031018 | endocrine pancreas development | TAS | biological_process |
| GO:0042866 | pyruvate biosynthetic process | IEA | biological_process |