Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KPYR_HUMAN
Description:pyruvate kinase, liver and RBC [Source:HGNC Symbol;Acc:9020]
Location:chr1 q22
Node attribute:PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S43YLRRAsVAQLTPhosphoSitePlus
S562GWRPGsGYTNIPK_CPhosphoSitePlus
Y564RPGSGyTNIMRPK_CPhosphoSitePlus
T556LVIVVtGWRPGHPRD; SysPTM
Y218VGGRIyIDDGLPKPhosphoSitePlus
S26RDLAKsILIGAHPRD
Y38GGPAGyLRRASPhosphoSitePlus
T525LVIVVtGWRPGHPRD
S261FVRKAsDVAAVHPRD
S292FVRKAsDVAAVHPRD
S292FVRKAsDVAAVPKPhosphoSitePlus
T556LVIVVtGWRPGPK_CPhosphoSitePlus; SysPTM

Dephosphorylation site
KPYR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000339933R289LCOSMICOvarian Cancer21720365
ENSP00000339933G332VCOSMICHead and Neck Cancer21798893
ENSP00000339933E387KCOSMICMelanoma21499247
ENSP00000339933S17FBIOMARTBreast Cancer21930507, 21930502
ENSP00000339933G251SCOSMICMelanoma20016485

Differential expressed protein
KPYR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KPYR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRBP1_HUMANKPYR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00620Pyruvate metabolism
hsa00230Purine metabolism
hsa01100Metabolic pathways
hsa04950Maturity onset diabetes of the young
hsa04930Type II diabetes mellitus
hsa00010Glycolysis / Gluconeogenesis
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006006glucose metabolic processTASbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0001666response to hypoxiaIEAbiological_process
GO:0007584response to nutrientIEAbiological_process
GO:0033198response to ATPIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0003824catalytic activityIEAmolecular_function
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0006096glycolysisIEAbiological_process
GO:0051707response to other organismIEAbiological_process
GO:0051591response to cAMPIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0009408response to heatIEAbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0031325positive regulation of cellular metabolic processTASbiological_process
GO:0005975carbohydrate metabolic processIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0006112energy reserve metabolic processTASbiological_process
GO:0006754ATP biosynthetic processIEAbiological_process
GO:0010038response to metal ionIEAbiological_process
GO:0030955potassium ion bindingIEAmolecular_function
GO:0004743pyruvate kinase activityIEAmolecular_function
GO:0010226response to lithium ionIEAbiological_process
GO:0032869cellular response to insulin stimulusIEAbiological_process
GO:0031018endocrine pancreas developmentTASbiological_process
GO:0042866pyruvate biosynthetic processIEAbiological_process


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