| UniProt/SwissProt ID: | MAST2_HUMAN |
| Description: | microtubule associated serine/threonine kinase 2 [Source:HGNC Symbol;Acc:19035] |
| Location: | chr1 p34.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1429 | TSRKHsLDLPH | PhosphoSitePlus | |
| S290 | EEGRQsPAMRP | DUF1908 | PhosphoSitePlus |
| S995 | GRSSGsSPAME | PhosphoSitePlus | |
| S900 | SWVIGsPEILR | PhosphoSitePlus; HPRD; phosphoELM | |
| S993 | AVGRSsGSSPA | PhosphoSitePlus | |
| T1508 | SSEDDtEEGPE | phosphoELM | |
| S855 | NKVYSsMERLS | PhosphoSitePlus | |
| T279 | TKHFStESVPD | DUF1908 | PhosphoSitePlus |
| S209 | SPRNFsPNAPA | HPRD | |
| S1503 | IREVDsSEDDT | phosphoELM | |
| S281 | HFSTEsVPDEE | DUF1908 | PhosphoSitePlus |
| S860 | SMERLsLLEER | PhosphoSitePlus | |
| S920 | HTESDsSPPMT | PhosphoSitePlus | |
| S66 | VVTGVsPLLFR | PhosphoSitePlus; HPRD | |
| S305 | LSPGRsPVSFD | DUF1908 | PhosphoSitePlus |
| S230 | DGRRWsLASLP | DUF1908 | PhosphoSitePlus |
| S191 | LPRPHsPLHGH | PhosphoSitePlus | |
| S1393 | LSRPKsAEPPR | PhosphoSitePlus | |
| S297 | AMRPRsRSLSP | DUF1908 | PhosphoSitePlus |
| S144 | RMRNQsLGQSA | PhosphoSitePlus | |
| S204 | NSPLDsPRNFS | DUF1908 | PhosphoSitePlus |
| S1275 | SLSPRsPTQGY | PhosphoSitePlus | |
| S278 | LTKHFsTESVP | DUF1908 | PhosphoSitePlus |
| S209 | SPRNFsPNAPA | DUF1908 | PhosphoSitePlus |
| S1399 | AEPPRsPLLKR | PhosphoSitePlus | |
| S148 | QSLGQsAPSLT | PhosphoSitePlus; HPRD | |
| S876 | TKRSLsEEKED | PhosphoSitePlus | |
| Y461 | CDIPRyIVSQL | DUF1908 | PhosphoSitePlus |
| S301 | RSRSLsPGRSP | DUF1908 | PhosphoSitePlus |
| S1435 | LDLPHsELKKE | PhosphoSitePlus | |
| T274 | ELHFLtKHFST | DUF1908 | PhosphoSitePlus |
| S151 | GQSAPsLTAGL | PhosphoSitePlus; HPRD | |
| S92 | LQRQLsQDDCK | PhosphoSitePlus | |
| S301 | RSRSLsPGRSP | HPRD | |
| S895 | KGRDRsWVIGS | PhosphoSitePlus | |
| S996 | RSSGSsPAMET | PhosphoSitePlus | |
| T82 | DIFSStGKVKL | PhosphoSitePlus | |
| S1340 | RKSAGsIPLSP | PhosphoSitePlus | |
| S1425 | KKLATsRKHSL | PhosphoSitePlus | |
| Y461 | CDIPRyIVSQL | HPRD | |
| S1032 | RHRLLsGDSTE | PhosphoSitePlus | |
| S854 | FNKVYsSMERL | PhosphoSitePlus | |
| T867 | LEERRtPPPTK | PhosphoSitePlus | |
| S81 | PDIFSsTGKVK | PhosphoSitePlus | |
| Y853 | RFNKVySSMER | PhosphoSitePlus | |
| S74 | LFRKLsNPDIF | PhosphoSitePlus; HPRD; phosphoELM | |
| S1351 | LAHTPsPPPPT | PhosphoSitePlus | |
| T1349 | SPLAHtPSPPP | PhosphoSitePlus | |
| S299 | RPRSRsLSPGR | DUF1908 | PhosphoSitePlus |
| Y812 | EDDTSyFDTRS | Pkinase_C | PhosphoSitePlus |
| T185 | SSTSPtLPRPH | PhosphoSitePlus | |
| S299 | RPRSRsLSPGR | HPRD | |
| T871 | RTPPPtKRSLS | PhosphoSitePlus | |
| S1771 | QKSEPsLRRGQ | PhosphoSitePlus | |
| S1768 | PLTQKsEPSLR | PhosphoSitePlus | |
| Dephosphorylation site |
| MAST2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000354671 | L91V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000354671 | T274A | COSMIC | Gastric Cancer | 21097718 | ENSP00000354671 | K1420N | COSMIC | Biliary Tract Cancer | 18772397 | ENSP00000354671 | Y625N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000354671 | P459A | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000354671 | P730L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000354671 | P1548L | COSMIC | Skin Cancer | 21984974 | ENSP00000354671 | S131L | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000354671 | P1382L | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000354671 | P730L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000354671 | G655A | HPI | Breast Cancer | 17344846 | ENSP00000354671 | R537H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000354671 | K275E | HPI | Ovarian Cancer | 17344846 | ENSP00000354671 | E746K | COSMIC | Gastric Cancer | 21097718 | ENSP00000354671 | Y625N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000354671 | R537H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000354671 | *1799Y | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| MAST2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MAST2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MAST2_HUMAN | SCG1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAST2_HUMAN | UB2L3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAST2_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MAST2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0015630 | microtubule cytoskeleton | IEA | cellular_component |
| GO:0048515 | spermatid differentiation | ISS | biological_process |
| GO:0006468 | protein phosphorylation | ISS | biological_process |
| GO:0000287 | magnesium ion binding | ISS | molecular_function |
| GO:0005524 | ATP binding | ISS | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045075 | regulation of interleukin-12 biosynthetic process | ISS | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0008017 | microtubule binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0019902 | phosphatase binding | IPI | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |