Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MAST2_HUMAN
Description:microtubule associated serine/threonine kinase 2 [Source:HGNC Symbol;Acc:19035]
Location:chr1 p34.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1429TSRKHsLDLPHPhosphoSitePlus
S290EEGRQsPAMRPDUF1908PhosphoSitePlus
S995GRSSGsSPAMEPhosphoSitePlus
S900SWVIGsPEILRPhosphoSitePlus; HPRD; phosphoELM
S993AVGRSsGSSPAPhosphoSitePlus
T1508SSEDDtEEGPEphosphoELM
S855NKVYSsMERLSPhosphoSitePlus
T279TKHFStESVPDDUF1908PhosphoSitePlus
S209SPRNFsPNAPAHPRD
S1503IREVDsSEDDTphosphoELM
S281HFSTEsVPDEEDUF1908PhosphoSitePlus
S860SMERLsLLEERPhosphoSitePlus
S920HTESDsSPPMTPhosphoSitePlus
S66VVTGVsPLLFRPhosphoSitePlus; HPRD
S305LSPGRsPVSFDDUF1908PhosphoSitePlus
S230DGRRWsLASLPDUF1908PhosphoSitePlus
S191LPRPHsPLHGHPhosphoSitePlus
S1393LSRPKsAEPPRPhosphoSitePlus
S297AMRPRsRSLSPDUF1908PhosphoSitePlus
S144RMRNQsLGQSAPhosphoSitePlus
S204NSPLDsPRNFSDUF1908PhosphoSitePlus
S1275SLSPRsPTQGYPhosphoSitePlus
S278LTKHFsTESVPDUF1908PhosphoSitePlus
S209SPRNFsPNAPADUF1908PhosphoSitePlus
S1399AEPPRsPLLKRPhosphoSitePlus
S148QSLGQsAPSLTPhosphoSitePlus; HPRD
S876TKRSLsEEKEDPhosphoSitePlus
Y461CDIPRyIVSQLDUF1908PhosphoSitePlus
S301RSRSLsPGRSPDUF1908PhosphoSitePlus
S1435LDLPHsELKKEPhosphoSitePlus
T274ELHFLtKHFSTDUF1908PhosphoSitePlus
S151GQSAPsLTAGLPhosphoSitePlus; HPRD
S92LQRQLsQDDCKPhosphoSitePlus
S301RSRSLsPGRSPHPRD
S895KGRDRsWVIGSPhosphoSitePlus
S996RSSGSsPAMETPhosphoSitePlus
T82DIFSStGKVKLPhosphoSitePlus
S1340RKSAGsIPLSPPhosphoSitePlus
S1425KKLATsRKHSLPhosphoSitePlus
Y461CDIPRyIVSQLHPRD
S1032RHRLLsGDSTEPhosphoSitePlus
S854FNKVYsSMERLPhosphoSitePlus
T867LEERRtPPPTKPhosphoSitePlus
S81PDIFSsTGKVKPhosphoSitePlus
Y853RFNKVySSMERPhosphoSitePlus
S74LFRKLsNPDIFPhosphoSitePlus; HPRD; phosphoELM
S1351LAHTPsPPPPTPhosphoSitePlus
T1349SPLAHtPSPPPPhosphoSitePlus
S299RPRSRsLSPGRDUF1908PhosphoSitePlus
Y812EDDTSyFDTRSPkinase_CPhosphoSitePlus
T185SSTSPtLPRPHPhosphoSitePlus
S299RPRSRsLSPGRHPRD
T871RTPPPtKRSLSPhosphoSitePlus
S1771QKSEPsLRRGQPhosphoSitePlus
S1768PLTQKsEPSLRPhosphoSitePlus

Dephosphorylation site
MAST2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354671L91VCOSMICOvarian Cancer21720365
ENSP00000354671T274ACOSMICGastric Cancer21097718
ENSP00000354671K1420NCOSMICBiliary Tract Cancer18772397
ENSP00000354671Y625NCOSMICOvarian Cancer21720365
ENSP00000354671P459ADing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000354671P730LTCGAOvarian Cancer21720365, 18772890
ENSP00000354671P1548LCOSMICSkin Cancer21984974
ENSP00000354671S131LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000354671P1382LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000354671P730LCOSMICOvarian Cancer21720365
ENSP00000354671G655AHPIBreast Cancer17344846
ENSP00000354671R537HTCGAOvarian Cancer21720365, 18772890
ENSP00000354671K275EHPIOvarian Cancer17344846
ENSP00000354671E746KCOSMICGastric Cancer21097718
ENSP00000354671Y625NTCGAOvarian Cancer21720365, 18772890
ENSP00000354671R537HCOSMICOvarian Cancer21720365
ENSP00000354671*1799YCOSMICOvarian Cancer21720365

Differential expressed protein
MAST2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MAST2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MAST2_HUMANSCG1_HUMANkinase -> substrateRobert H Newman (2013)
MAST2_HUMANUB2L3_HUMANkinase -> substrateRobert H Newman (2013)
MAST2_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MAST2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0015630microtubule cytoskeletonIEAcellular_component
GO:0048515spermatid differentiationISSbiological_process
GO:0006468protein phosphorylationISSbiological_process
GO:0000287magnesium ion bindingISSmolecular_function
GO:0005524ATP bindingISSmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0045075regulation of interleukin-12 biosynthetic processISSbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0008017microtubule bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0019902phosphatase bindingIPImolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function


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