| UniProt/SwissProt ID: | SPHK2_HUMAN |
| Description: | sphingosine kinase 2 [Source:HGNC Symbol;Acc:18859] |
| Location: | chr19 q13.33 |
| Node attribute: | substrate; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S105 | CCTLRsRSPSD | PhosphoSitePlus | |
| T402 | AKSELtLTPDP | PhosphoSitePlus | |
| S355 | FRALGsARFTL | PhosphoSitePlus | |
| S387 | TVEPAsPTPAH | PhosphoSitePlus; HPRD | |
| S399 | LPRAKsELTLT | PhosphoSitePlus | |
| T371 | LATLHtYRGRL | PhosphoSitePlus | |
| T389 | EPASPtPAHSL | HPRD; phosphoELM | |
| T359 | GSARFtLGTVL | PhosphoSitePlus | |
| S419 | SPLHRsVSDLP | PhosphoSitePlus | |
| T404 | SELTLtPDPAP | PhosphoSitePlus; HPRD | |
| S473 | DPLLSsPPGSP | PhosphoSitePlus | |
| S421 | LHRSVsDLPLP | PhosphoSitePlus | |
| S414 | PPMAHsPLHRS | PhosphoSitePlus; HPRD | |
| S484 | KAALHsPVSEG | HPRD; phosphoELM | |
| S477 | SSPPGsPKAAL | PhosphoSitePlus | |
| S107 | TLRSRsPSDSA | PhosphoSitePlus | |
| T614 | RLEPLtPRGVL | PhosphoSitePlus | |
| Dephosphorylation site |
| SPHK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000245222 | P407Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000245222 | V242I | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000245222 | G194D | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| SPHK2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SPHK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | SPHK2_HUMAN | kinase -> substrate | KEGG |
| SPHK2_HUMAN | RASH_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04370 | VEGF signaling pathway |
| hsa05152 | Tuberculosis |
| hsa01100 | Metabolic pathways |
| hsa04020 | Calcium signaling pathway |
| hsa00600 | Sphingolipid metabolism |
| hsa04666 | Fc gamma R-mediated phagocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005765 | lysosomal membrane | IEA | cellular_component |
| GO:0043066 | negative regulation of apoptotic process | NAS | biological_process |
| GO:0030148 | sphingolipid biosynthetic process | TAS | biological_process |
| GO:0016020 | membrane | IDA | cellular_component |
| GO:0001568 | blood vessel development | IEA | biological_process |
| GO:0007205 | protein kinase C-activating G-protein coupled rece | IEA | biological_process |
| GO:0006665 | sphingolipid metabolic process | TAS | biological_process |
| GO:0004143 | diacylglycerol kinase activity | IEA | molecular_function |
| GO:0017016 | Ras GTPase binding | NAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005829 | cytosol | IDA | cellular_component |
| GO:0008284 | positive regulation of cell proliferation | IEA | biological_process |
| GO:0006670 | sphingosine metabolic process | IEA | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0007420 | brain development | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008481 | sphinganine kinase activity | NAS | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0017050 | D-erythro-sphingosine kinase activity | IEA | molecular_function |
| GO:0008283 | cell proliferation | NAS | biological_process |
| GO:0006669 | sphinganine-1-phosphate biosynthetic process | NAS | biological_process |
| GO:0006644 | phospholipid metabolic process | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |