Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SPHK2_HUMAN
Description:sphingosine kinase 2 [Source:HGNC Symbol;Acc:18859]
Location:chr19 q13.33
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S105CCTLRsRSPSDPhosphoSitePlus
T402AKSELtLTPDPPhosphoSitePlus
S355FRALGsARFTLPhosphoSitePlus
S387TVEPAsPTPAHPhosphoSitePlus; HPRD
S399LPRAKsELTLTPhosphoSitePlus
T371LATLHtYRGRLPhosphoSitePlus
T389EPASPtPAHSLHPRD; phosphoELM
T359GSARFtLGTVLPhosphoSitePlus
S419SPLHRsVSDLPPhosphoSitePlus
T404SELTLtPDPAPPhosphoSitePlus; HPRD
S473DPLLSsPPGSPPhosphoSitePlus
S421LHRSVsDLPLPPhosphoSitePlus
S414PPMAHsPLHRSPhosphoSitePlus; HPRD
S484KAALHsPVSEGHPRD; phosphoELM
S477SSPPGsPKAALPhosphoSitePlus
S107TLRSRsPSDSAPhosphoSitePlus
T614RLEPLtPRGVLPhosphoSitePlus

Dephosphorylation site
SPHK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000245222P407QCOSMICHead and Neck Cancer21798893
ENSP00000245222V242IBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000245222G194DCOSMICLung Cancer20668451

Differential expressed protein
SPHK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SPHK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANSPHK2_HUMANkinase -> substrateKEGG
SPHK2_HUMANRASH_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04370VEGF signaling pathway
hsa05152Tuberculosis
hsa01100Metabolic pathways
hsa04020Calcium signaling pathway
hsa00600Sphingolipid metabolism
hsa04666Fc gamma R-mediated phagocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005765lysosomal membraneIEAcellular_component
GO:0043066negative regulation of apoptotic processNASbiological_process
GO:0030148sphingolipid biosynthetic processTASbiological_process
GO:0016020membraneIDAcellular_component
GO:0001568blood vessel developmentIEAbiological_process
GO:0007205protein kinase C-activating G-protein coupled receIEAbiological_process
GO:0006665sphingolipid metabolic processTASbiological_process
GO:0004143diacylglycerol kinase activityIEAmolecular_function
GO:0017016Ras GTPase bindingNASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005829cytosolIDAcellular_component
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0006670sphingosine metabolic processIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0007420brain developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008481sphinganine kinase activityNASmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0017050D-erythro-sphingosine kinase activityIEAmolecular_function
GO:0008283cell proliferationNASbiological_process
GO:0006669sphinganine-1-phosphate biosynthetic processNASbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0005515protein bindingIEAmolecular_function


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