| UniProt/SwissProt ID: | RAP1A_HUMAN |
| Description: | RAP1A, member of RAS oncogene family [Source:HGNC Symbol;Acc:9855] |
| Location: | chr1 p13.2 |
| Node attribute: | PPI(source); substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S11 | LVVLGsGGVGK | Ras | PhosphoSitePlus |
| S180 | KPKKKsCLLL_ | PhosphoSitePlus | |
| S11 | LVVLGsGGVGK | HPRD | |
| Y159 | VNEIFyDLVRQ | Ras | PhosphoSitePlus |
| S180 | KPKKKsCL | PRKACA | HPRD |
| S180 | KPKKKsCLLL | PKA_group | RegPhos |
| S180 | KPKKKsCLLL | PKACa | RegPhos |
| S39 | PTIEDsYRKQV | Ras | PhosphoSitePlus |
| S180 | KPKKKsCL | PKA_group | phosphoELM |
| Dephosphorylation site |
| RAP1A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| RAP1A_HUMAN do not have mutation site. |
| Differential expressed protein |
| RAP1A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RAP1A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| YES_HUMAN | RAP1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC2_HUMAN | RAP1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| OXSR1_HUMAN | RAP1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM1_HUMAN | RAP1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR4_HUMAN | RAP1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK16_HUMAN | RAP1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK07_HUMAN | RAP1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | RAP1A_HUMAN | kinase -> substrate | KEGG; HPRD |
| M3K7_HUMAN | RAP1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RAP1A_HUMAN | BRAF_HUMAN | other | KEGG |
| RAP1A_HUMAN | MK08_HUMAN | other | KEGG |
| RPGF1_HUMAN | RAP1A_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| hsa04510 | Focal adhesion |
| hsa04722 | Neurotrophin signaling pathway |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04720 | Long-term potentiation |
| hsa05211 | Renal cell carcinoma |
| hsa04062 | Chemokine signaling pathway |
| hsa04972 | Pancreatic secretion |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006913 | nucleocytoplasmic transport | IEA | biological_process |
| GO:0017016 | Ras GTPase binding | IEA | molecular_function |
| GO:0006184 | GTP catabolic process | IEA | biological_process |
| GO:0032045 | guanyl-nucleotide exchange factor complex | IEA | cellular_component |
| GO:0008283 | cell proliferation | IEA | biological_process |
| GO:0006886 | intracellular protein transport | IEA | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0000186 | activation of MAPKK activity | TAS | biological_process |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0050796 | regulation of insulin secretion | TAS | biological_process |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |