Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRS6A_HUMAN
Description:proteasome (prosome, macropain) 26S subunit, ATPase, 3 [Source:HGNC Symbol;Acc:9549]
Location:chr11 p11.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S345PALLRsGRLDRAAAPhosphoSitePlus
Y132STRQTyFLPVIPhosphoSitePlus
S9LPNIEsPVTRQPhosphoSitePlus; HPRD

Dephosphorylation site
PRS6A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000298852N207HCOSMICOvarian Cancer21720365
ENSP00000298852Q184*COSMICOvarian Cancer21720365
ENSP00000298852E353*COSMICOvarian Cancer21720365
ENSP00000298852D98HCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000298852acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000298852acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000298852acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000298852acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343

Hyperphosphorylation site
PRS6A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KKCC1_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
CLK1_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PRS6A_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016787hydrolase activityIEAmolecular_function
GO:0006310DNA recombinationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0000075cell cycle checkpointTASbiological_process
GO:0000502proteasome complexTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0003713transcription coactivator activityTASmolecular_function
GO:0000932cytoplasmic mRNA processing bodyISScellular_component
GO:0010467gene expressionTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0030163protein catabolic processIEAbiological_process
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0002479antigen processing and presentation of exogenous pTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0016887ATPase activityIEAmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0051436negative regulation of ubiquitin-protein ligase acTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0000209protein polyubiquitinationTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0017111nucleoside-triphosphatase activityIEAmolecular_function
GO:0016032viral reproductionTASbiological_process
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0022624proteasome accessory complexIEAcellular_component
GO:0006977DNA damage response, signal transduction by p53 clTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0003714transcription corepressor activityTASmolecular_function
GO:0006281DNA repairIEAbiological_process
GO:0009378four-way junction helicase activityIEAmolecular_function
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0006521regulation of cellular amino acid metabolic procesTASbiological_process
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0001824blastocyst developmentIEAbiological_process


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