Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRKDC_HUMAN
Description:protein kinase, DNA-activated, catalytic polypeptide [Source:HGNC Symbol;Acc:9413]
Location:chr8 q11.21
Node attribute:substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T3811LENTVtLKDLLPI3_PI4_kinasePhosphoSitePlus
Y779EEWSIyIDRHVPhosphoSitePlus
S2624RTQEGsLSARWPhosphoSitePlus; phosphoELM; RegPhos
T2647HDFTLtQTADGPhosphoSitePlus; phosphoELM
S3205LPEDNsMNVDQFATPhosphoSitePlus
S3290HCRSRsQGCSEFATPhosphoSitePlus
S1352TLLNTsPEGWKHPRD
Y3859AYMLMyKGANRPI3_PI4_kinasePhosphoSitePlus
Y3855HDVGAyMLMYKPI3_PI4_kinasePhosphoSitePlus
S2674DHTSPsSDSLLPhosphoSitePlus; HPRD; phosphoELM
T1694KGQAVtLLPFFHPRD
T1856LKSRFtKLNESNUC194PhosphoSitePlus
T2792HSSLItPLQAVHPRD; phosphoELM
S841KTKNLsSNEAIPhosphoSitePlus
S552DEAFFsVNSSSPhosphoSitePlus
S1065FKRLYsLALHPPhosphoSitePlus
S1470HNILPsQSTDLPhosphoSitePlus
S492LIRICsKPVVLPhosphoSitePlus
T2609PMFVEtQASQGDNA-PKphosphoELM
T2638GQIRAtQQQHDDNA-PKphosphoELM
S2789QIKHSsLITPLHPRD; phosphoELM
T2620TLQTRtQEGSLDNAPKRegPhos
S2053GVQSYsYSSQDNUC194PhosphoSitePlus
Y2440CLDIIyKMMPKPhosphoSitePlus
T1275FIGERtVGALQHPRD
S893REKRLsFAVPFPhosphoSitePlus; HPRD; phosphoELM
T2615QASQGtLQTRTPhosphoSitePlus
S2675HTSPSsDSLLFHPRD; phosphoELM
T2649FTLTQtADGRSHPRD; phosphoELM; RegPhos
T2647HDFTLtQTADGDNA-PKphosphoELM
Y1064LFKRLySLALHPhosphoSitePlus
T516SGEVRtGKWKVPhosphoSitePlus
S1546ASLGSsQGSVIPhosphoSitePlus
T2638GQIRAtQQQHDDNAPKRegPhos
T2638GQIRAtQQQHDPhosphoSitePlus; phosphoELM
T2647HDFTLtQTADGPRKDCHPRD
S2655ADGRSsFDWLTPhosphoSitePlus
S3233SSLIRsCKFSMFATPhosphoSitePlus
T2609PMFVEtQASQGautocatalysisRegPhos
S2034SYLADsTLSEENUC194PhosphoSitePlus
S2051STGVQsYSYSSNUC194PhosphoSitePlus
T2647HDFTLtQTADGautocatalysisRegPhos
T2620TLQTRtQEGSLPhosphoSitePlus; phosphoELM
Y682AKKIKyFEGVSPhosphoSitePlus
T2609PMFVEtQASQGDNAPKRegPhos
S2612VETQAsQGTLQPRKDCHPRD
S4026LKKGGsWIQEIPhosphoSitePlus; HPRD; phosphoELM
T3663DFNDItNMLLLPhosphoSitePlus
T2620TLQTRtQEGSLPRKDCHPRD
Y2743KLSLMyARKGVPhosphoSitePlus; HPRD; phosphoELM
S842TKNLSsNEAISPhosphoSitePlus
Y721VKMKQyKDELLPhosphoSitePlus
Y3791LQLRTySVVPMPI3_PI4_kinasePhosphoSitePlus
S3365LELSGsSSEDSHPRD
S1052QQQEKsPVNTKPhosphoSitePlus; HPRD
S2624RTQEGsLSARWDNAPKRegPhos
S1841LREFFsTIVVDHPRD
Y2329GLILRyVMERKPhosphoSitePlus
T2638GQIRAtQQQHDPRKDCHPRD
Y667LISGFyKLLSIPhosphoSitePlus
T2671PLVDHtSPSSDHPRD; phosphoELM
S511EDHRAsGEVRTPhosphoSitePlus
T2609PMFVEtQASQGPRKDCHPRD
T1621LKLATtILQHWPhosphoSitePlus
S3205LPEDNsMNVDQDNAPKRegPhos
S2612VETQAsQGTLQDNAPKRegPhos
Y1086AFNNIyREFREPhosphoSitePlus
S3500FISWIsHMVALPhosphoSitePlus
S2612VETQAsQGTLQPhosphoSitePlus; phosphoELM
S1545TASLGsSQGSVPhosphoSitePlus
T1620GLKLAtTILQHPhosphoSitePlus
T2638GQIRAtQQQHDautocatalysisRegPhos
S3233SSLIRsCKFSMHPRD
S1701LPFFTsLTGGSHPRD
S687YFEGVsPKSLKPhosphoSitePlus
S3205LPEDNsMNVDQPRKDCHPRD
Y2936RSIGEyDVLRGPhosphoSitePlus
T2609PMFVEtQASQGPhosphoSitePlus; phosphoELM
S3215QDGDPsDRMEVFATPhosphoSitePlus
S882DEMMKsYVAWDPhosphoSitePlus
S3982TGLMYsIMVHAHPRD
S2117QGEEDsVPRDLHPRD
S2599DWRFRsTVLTPPhosphoSitePlus; HPRD
T2603RSTVLtPMFVEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S2056SYSYSsQDPRPNUC194PhosphoSitePlus
S2612VETQAsQGTLQautocatalysisRegPhos
S2056SYSYSsQDPRPDNA-PKphosphoELM
S503PKGPEsESEDHPhosphoSitePlus
T1700LLPFFtSLTGGHPRD
S2814FSSLFsGILKEPhosphoSitePlus
S3205LPEDNsMNVDQHPRD; phosphoELM; RegPhos
S2677SPSSDsLLFAHHPRD; phosphoELM
T2620TLQTRtQEGSLDNA-PKphosphoELM
Y883EMMKSyVAWDRPhosphoSitePlus
T1481HHSVGtELLSLPhosphoSitePlus
T2647HDFTLtQTADGDNAPKRegPhos
Y2546ALNSLySPKIEHPRD
T2618QGTLQtRTQEGPhosphoSitePlus
S2672LVDHTsPSSDSPhosphoSitePlus; HPRD; phosphoELM
T1703FFTSLtGGSLEHPRD
Y3378VIAGLyQRAFQFATPhosphoSitePlus
S3497CWQFIsWISHMPhosphoSitePlus
S2117QGEEDsVPRDLNUC194PhosphoSitePlus
S2056SYSYSsQDPRPDNAPKRegPhos
T1842REFFStIVVDAHPRD
S3657LRMKLsDFNDIPhosphoSitePlus
S847SNEAIsLEEIRPhosphoSitePlus
S3489TKEISsVPCWQPhosphoSitePlus
T3950AFGSAtQFLPVPI3_PI4_kinasePhosphoSitePlus
S505GPESEsEDHRAPhosphoSitePlus
Y3828EEKAAyLSDPRPI3_PI4_kinasePhosphoSitePlus
S2612VETQAsQGTLQDNA-PKphosphoELM
T2600WRFRStVLTPMPhosphoSitePlus
T2645QQHDFtLTQTAPhosphoSitePlus; HPRD
S2624RTQEGsLSARWPRKDCHPRD
S229LKGLSsLLCNFHPRD
T137IKLLQtFRSSRPhosphoSitePlus; HPRD

Dephosphorylation site
PRKDC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000313420V386ICOSMICLung Cancer20668451
ENSP00000313420S702FCOSMICBreast Cancer20668451
ENSP00000313420S2592CCOSMICLung Cancer20668451
ENSP00000313420L3361VCOSMICLung Cancer20668451
ENSP00000313420E2342GCOSMICLung Cancer20668451
ENSP00000313420S936CDing2008, COSMICLung Cancer18948947, 20668451
ENSP00000313420A2031VCOSMICOvarian Cancer21720365
ENSP00000313420Y3474CBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000313420M3845IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000313420F2382LCOSMICLung Cancer20668451
ENSP00000313420M1879IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000313420S2625LBIOMARTBreast Cancer21930507, 21930502
ENSP00000313420R2635MDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000313420Gastric CancerMetastasiscell lineDown0.5517022644
ENSP00000313420Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000313420Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp5.818491314
ENSP00000313420Hepatocellular CarcinomaMetastasiscell lineUp1.619016532
ENSP00000313420Small cell lung carcinomaTreatment (none vs. isogenic Doxorubicin-resistant)cell lineDown0.4218654985
ENSP00000313420Gastric CancerMetastasiscell lineDown0.5517022644

Hyperphosphorylation site
PRKDC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PRKDC_HUMANXPA_HUMANkinase -> substrateHPRD
PRKDC_HUMANRFA2_HUMANkinase -> substrateHPRD
PRKDC_HUMANP53_HUMANkinase -> substrateHPRD
PRKDC_HUMANDNLI4_HUMANkinase -> substrateHPRD
PRKDC_HUMANHS90A_HUMANkinase -> substrateHPRD
PRKDC_HUMANSRF_HUMANkinase -> substrateHPRD
PRKDC_HUMANPRKDC_HUMANkinase -> substrateHPRD
PRKDC_HUMANGCR_HUMANkinase -> substrateHPRD
PRKDC_HUMANJUN_HUMANkinase -> substrateHPRD
ZAGL2_HUMANPRKDC_HUMANkinase -> substrateRegPhos
PRKDC_HUMANP53_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle
hsa03450Non-homologous end-joining

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002328pro-B cell differentiationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005958DNA-dependent protein kinase-DNA ligase 4 complexIDAcellular_component
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0033153T cell receptor V(D)J recombinationIEAbiological_process
GO:0031648protein destabilizationIEAbiological_process
GO:0006303double-strand break repair via nonhomologous end jTASbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0002360T cell lineage commitmentIEAbiological_process
GO:0001756somitogenesisIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0006464cellular protein modification processTASbiological_process
GO:0005488bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004672protein kinase activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0032869cellular response to insulin stimulusIMPbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0035234germ cell programmed cell deathIEAbiological_process
GO:0005730nucleolusIEAcellular_component
GO:0010332response to gamma radiationIEAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0030098lymphocyte differentiationIEAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0005667transcription factor complexIDAcellular_component
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0070419nonhomologous end joining complexIDAcellular_component
GO:0002326B cell lineage commitmentIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0006302double-strand break repairIEAbiological_process
GO:0033152immunoglobulin V(D)J recombinationIEAbiological_process
GO:0004677DNA-dependent protein kinase activityIDAmolecular_function
GO:0019899enzyme bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0000723telomere maintenanceIEAbiological_process


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