Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLCG2_HUMAN
Description:phospholipase C, gamma 2 (phosphatidylinositol-specific) [Source:HGNC Symbol;Acc:9066]
Location:chr16 q23.3
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y759DVSRMyVDPSELCKHPRD; RegPhos
Y753DINSLyDVSRMLckphosphoELM; RegPhos
Y482QQGELyMWDSIPhosphoSitePlus
Y1197SEEELySSCRQBTKHPRD; phosphoELM; RegPhos
Y759DVSRMyVDPSELckphosphoELM; RegPhos
Y759DVSRMyVDPSESRCphosphoELM
Y733KMRLRyPVTPEPhosphoSitePlus; HPRD; phosphoELM
Y743ELLERyNMERDFynphosphoELM; RegPhos
Y1217NQLFLyDTHQNBTKHPRD; phosphoELM; RegPhos
Y743ELLERyNMERDLynphosphoELM; RegPhos
Y1197SEEELySSCRQPhosphoSitePlus
Y647ESKPWyYDSLSSH2PhosphoSitePlus
Y720ELVSYyEKHSLSH2PhosphoSitePlus
Y495KWTRHyCAIADPhosphoSitePlus
S679REGSDsYAITFSH2PhosphoSitePlus
Y759DVSRMyVDPSEPhosphoSitePlus; phosphoELM; RegPhos
Y743ELLERyNMERDLckphosphoELM; RegPhos
Y811WWKGDyGTRIQSH3_1PhosphoSitePlus
Y1036NGRTGyVLQPEPI-PLC-YPhosphoSitePlus
Y753DINSLyDVSRMSRCphosphoELM
S756SLYDVsRMYVDPhosphoSitePlus
T1034SLNGRtGYVLQPI-PLC-YPhosphoSitePlus
T683DSYAItFRARGSH2PhosphoSitePlus
Y753DINSLyDVSRMSrcRegPhos
Y1048MRTEKyDPMPPPhosphoSitePlus
Y680EGSDSyAITFRSH2PhosphoSitePlus
S941YCKPTsKTKDNPI-PLC-YPhosphoSitePlus
Y759DVSRMyVDPSESrcRegPhos
Y753DINSLyDVSRMFYNHPRD; RegPhos
Y753DINSLyDVSRMBTKphosphoELM; RegPhos
Y753DINSLyDVSRMFynRegPhos
Y759DVSRMyVDPSELYNHPRD; RegPhos
Y242DASAVyLHDFQefhand_likePhosphoSitePlus
S789RSDELsFCRGASH3_1PhosphoSitePlus
T857ILDLNtYNVVKPHPhosphoSitePlus
Y759DVSRMyVDPSEFYNHPRD; RegPhos
Y858LDLNTyNVVKAPHPhosphoSitePlus
Y1020QTADKyMQMNHPI-PLC-YPhosphoSitePlus
S1265NSKFYs_____PhosphoSitePlus
Y780KALYDyKAKRSSH3_1PhosphoSitePlus
Y1217NQLFLyDTHQNPhosphoSitePlus
Y759DVSRMyVDPSELynRegPhos
T1219LFLYDtHQNLRPhosphoSitePlus
T276KFIDDtMRETAefhand_likePhosphoSitePlus
S1029NHALFsLNGRTPI-PLC-YPhosphoSitePlus
Y778TVKALyDYKAKSH3_1PhosphoSitePlus
Y936SDLVVyCKPTSPI-PLC-YPhosphoSitePlus
Y1264SNSKFyS____PhosphoSitePlus
S763MYVDPsEINPSPhosphoSitePlus
S965ETKADsIIRQKPI-PLC-YPhosphoSitePlus
S1261KRVSNsKFYS_PhosphoSitePlus
S1259REKRVsNSKFYPhosphoSitePlus
Y759DVSRMyVDPSEHCKHPRD; RegPhos
Y1137LRFVVyEEDMFC2PhosphoSitePlus
Y1217NQLFLyDTHQNLckphosphoELM
S160QTRRNsISLREPhosphoSitePlus
S677RKREGsDSYAISH2PhosphoSitePlus
Y371GKPVIyHGWTRPI-PLC-XPhosphoSitePlus
T276KFIDDtMRETAHPRD
Y753DINSLyDVSRMHCKHPRD; RegPhos
Y743ELLERyNMERDPhosphoSitePlus
Y1197SEEELySSCRQLckphosphoELM
Y759DVSRMyVDPSEFynRegPhos
T1045PESMRtEKYDPPhosphoSitePlus
S957FREIRsFVETKPI-PLC-YPhosphoSitePlus
Y818TRIQQyFPSNYSH3_1PhosphoSitePlus
Y753DINSLyDVSRMLYNHPRD; RegPhos
S994GQRVDsSNYDPPI-PLC-YPhosphoSitePlus
S1164KSGFRsVPLKNPhosphoSitePlus
Y753DINSLyDVSRMPhosphoSitePlus; phosphoELM; RegPhos
Y1245NQLQLyQEKCNPhosphoSitePlus; phosphoELM; RegPhos
Y753DINSLyDVSRMLynRegPhos
Y753DINSLyDVSRMLCKHPRD; RegPhos
Y759DVSRMyVDPSEBTKHPRD; phosphoELM; RegPhos

Dephosphorylation site
PLCG2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000352336Y1036DTCGAOvarian Cancer21720365, 18772890
ENSP00000352336Q924*COSMICOvarian Cancer20668451
ENSP00000352336D274NCOSMICHead and Neck Cancer21798893
ENSP00000352336A612SCOSMICLung Cancer20668451
ENSP00000352336H534LCOSMICHead and Neck Cancer21798893
ENSP00000352336C1249RBIOMARTBreast Cancer21930507, 21930502
ENSP00000352336D261YDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000352336P433LCOSMICLung Cancer20668451
ENSP00000352336T138MCOSMICLung Cancer20668451
ENSP00000352336G595RCOSMICLung Cancer20668451
ENSP00000352336V1189FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
PLCG2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PLCG2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LCK_HUMANPLCG2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KSYK_HUMANPLCG2_HUMANkinase -> substrateKEGG; NetPath
TEC_HUMANPLCG2_HUMANkinase -> substrateNetPath
ITK_HUMANPLCG2_HUMANkinase -> substrateNetPath
BTK_HUMANPLCG2_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
LYN_HUMANPLCG2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FYN_HUMANPLCG2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
HCK_HUMANPLCG2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANPLCG2_HUMANkinase -> substrateRegPhos
PLCG2_HUMANGRP3_HUMANotherKEGG
PLCG2_HUMANKPCB_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05223Non-small cell lung cancer
hsa04666Fc gamma R-mediated phagocytosis
hsa04020Calcium signaling pathway
hsa00562Inositol phosphate metabolism
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04012ErbB signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04370VEGF signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04064NF-kappa B signaling pathway
hsa05200Pathways in cancer
hsa05110Vibrio cholerae infection
hsa01100Metabolic pathways
hsa04722Neurotrophin signaling pathway
hsa05214Glioma
hsa04380Osteoclast differentiation
hsa04070Phosphatidylinositol signaling system
hsa04664Fc epsilon RI signaling pathway
hsa04662B cell receptor signaling pathway
hsa05169Epstein-Barr virus infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0009395phospholipid catabolic processIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0019722calcium-mediated signalingNASbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0004435phosphatidylinositol phospholipase C activityIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0030183B cell differentiationISSbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0002316follicular B cell differentiationIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0008081phosphoric diester hydrolase activityIEAmolecular_function
GO:0032959inositol trisphosphate biosynthetic processIEAbiological_process
GO:0032237activation of store-operated calcium channel activIEAbiological_process
GO:0006661phosphatidylinositol biosynthetic processIDAbiological_process
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0030168platelet activationTASbiological_process
GO:0051209release of sequestered calcium ion into cytosolIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0030183B cell differentiationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004629phospholipase C activityTASmolecular_function
GO:0016055Wnt receptor signaling pathwayTASbiological_process
GO:0043069negative regulation of programmed cell deathIEAbiological_process


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