Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:OPRM_HUMAN
Description:opioid receptor, mu 1 [Source:HGNC Symbol;Acc:8156]
Location:chr6 q25.2
Node attribute:substrate; GPCR; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S377TRDHPsTANTVPhosphoSitePlus; HPRD
S268SVRMLsGSKEK7tm_1PhosphoSitePlus
Y338LNPVLyAFLDE7tm_1PhosphoSitePlus
T356EFCIPtSSNIEHPRD
T356EFCIPtSSNIEADRBK1HPRD
T372RIRQNtRDHPSPhosphoSitePlus; HPRD
S365IEQQNsTRIRQPhosphoSitePlus; HPRD
T396NLEAEtAPHPRD
S358CIPTSsNIEQQHPRD
T182ALDFRtPRNAKHPRD
S270RMLSGsKEKDR7tm_1PhosphoSitePlus
T378RDHPStANTVDPhosphoSitePlus
Y168MSVDRyIAVCH7tm_1PhosphoSitePlus
S358CIPTSsNIEQQADRBK1HPRD
S263ILRLKsVRMLS7tm_1PhosphoSitePlus
T182ALDFRtPRNAKADRBK2HPRD

Dephosphorylation site
OPRM_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000399359*404SCOSMICCentral Nervous System Neoplasms10560660
ENSP00000394624S363FCOSMICSkin Cancer21984974
ENSP00000394624R440QCOSMICSkin Cancer21984974
ENSP00000353598R369CCOSMICSkin Cancer21984974
ENSP00000394624E483KCOSMICHead and Neck Cancer21798893
ENSP00000229768S270FCOSMICSkin Cancer21984974
ENSP00000229768R369CCOSMICSkin Cancer21984974
ENSP00000353598R347QCOSMICSkin Cancer21984974
ENSP00000353598S270FCOSMICSkin Cancer21984974
ENSP00000229768R278QCOSMICHead and Neck Cancer21798893
ENSP00000394624R462CCOSMICSkin Cancer21984974
ENSP00000229768R347QCOSMICSkin Cancer21984974
ENSP00000353598R278QCOSMICHead and Neck Cancer21798893
ENSP00000328264R369CBIOMARTchronic lymphocytic leukemia21930507, 21930502

Differential expressed protein
OPRM_HUMAN is not differential expressed protein.

Hyperphosphorylation site
OPRM_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
COLI_HUMANOPRM_HUMANligand -> receptorHPMR
OPRM_HUMANGNAI3_HUMANGPCR -> GproteingpDB
OPRM_HUMANGNAO_HUMANGPCR -> GproteingpDB
OPRM_HUMANGNAI1_HUMANGPCR -> GproteingpDB
OPRM_HUMANGNAI2_HUMANGPCR -> GproteingpDB
ARBK1_HUMANOPRM_HUMANkinase -> substrateHPRD
ARBK2_HUMANOPRM_HUMANkinase -> substrateHPRD
STAT6_HUMANOPRM_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05032Morphine addiction
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004979beta-endorphin receptor activityIMPmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0043950positive regulation of cAMP-mediated signalingIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0033554cellular response to stressIMPbiological_process
GO:0045019negative regulation of nitric oxide biosynthetic pIDAbiological_process
GO:0007200phospholipase C-activating G-protein coupled recepIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0045429positive regulation of nitric oxide biosynthetic pIDAbiological_process
GO:0038047morphine receptor activityISSmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0038047morphine receptor activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0007600sensory perceptionNASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0050795regulation of behaviorIMPbiological_process
GO:0005245voltage-gated calcium channel activityIEAmolecular_function
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0043951negative regulation of cAMP-mediated signalingIDAbiological_process
GO:0007610behaviorIEAbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0071315cellular response to morphineIEAbiological_process
GO:0019233sensory perception of painIEAbiological_process
GO:2000310regulation of N-methyl-D-aspartate selective glutaIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007626locomotory behaviorIEAbiological_process
GO:0051481reduction of cytosolic calcium ion concentrationIDAbiological_process
GO:0004985opioid receptor activityIEAmolecular_function
GO:0007204elevation of cytosolic calcium ion concentrationIDAbiological_process
GO:0004930G-protein coupled receptor activityISSmolecular_function
GO:0007191adenylate cyclase-activating dopamine receptor sigIEAbiological_process
GO:0007194negative regulation of adenylate cyclase activityIEAbiological_process
GO:0038003opioid receptor signaling pathwayIEAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0007194negative regulation of adenylate cyclase activityISSbiological_process
GO:0007200phospholipase C-activating G-protein coupled recepISSbiological_process
GO:0005245voltage-gated calcium channel activityISSmolecular_function
GO:0019233sensory perception of painISSbiological_process
GO:0007610behaviorNASbiological_process
GO:0050769positive regulation of neurogenesisISSbiological_process
GO:0005783endoplasmic reticulumTAScellular_component
GO:0001965G-protein alpha-subunit bindingIDAmolecular_function
GO:0005794Golgi apparatusTAScellular_component
GO:2000310regulation of N-methyl-D-aspartate selective glutaISSbiological_process
GO:0048149behavioral response to ethanolIMPbiological_process
GO:0050769positive regulation of neurogenesisIEAbiological_process
GO:0007187G-protein coupled receptor signaling pathway, coupTASbiological_process
GO:0061358negative regulation of Wnt protein secretionIMPbiological_process
GO:0007193adenylate cyclase-inhibiting G-protein coupled recIEAbiological_process