Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NOTC1_HUMAN
Description:notch 1 [Source:HGNC Symbol;Acc:7881]
Location:chr9 q34.3
Node attribute:PPI(source); cleavage(target); glycosylation(target); receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y2323MVPNQyNPLRGPhosphoSitePlus
S1900LETGNsEEEEDPhosphoSitePlus
S1951RLLEAsADANIAnk_2PhosphoSitePlus
S2522PDQWSsSSPHSDUF3454PhosphoSitePlus
Y2145CSPNGyLGSLKPhosphoSitePlus
T1927NQTDRtGETALAnk_2PhosphoSitePlus
T1861SAMAPtPPQGEHPRD
T1930DRTGEtALHLAAnk_2PhosphoSitePlus
T1897GGGLEtGNSEEPhosphoSitePlus
S900CQAGYsGRNCEEGF_CAPhosphoSitePlus
S2521SPDQWsSSSPHDUF3454PhosphoSitePlus
S2136GTPTLsPPLCSPhosphoSitePlus
S2523DQWSSsSPHSNDUF3454PhosphoSitePlus
S2524QWSSSsPHSNVDUF3454PhosphoSitePlus

Dephosphorylation site
NOTC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000277541C478FCOSMICSkin Cancer21984974
ENSP00000277541P517SCOSMICSkin Cancer21984974
ENSP00000277541V1671IBIOMARTLung Cancer21930507, 21930502
ENSP00000277541Q1923*COSMICSkin Cancer21984974
ENSP00000277541E719*COSMICHead and Neck Cancer21798893
ENSP00000277541R353HCOSMICHead and Neck Cancer21798897
ENSP00000277541R1984*COSMICHead and Neck Cancer21798897
ENSP00000277541D1517NCOSMICHead and Neck Cancer21798893
ENSP00000277541G484VCOSMICHead and Neck Cancer21798897
ENSP00000277541C554*COSMICHead and Neck Cancer21798897
ENSP00000277541F1291LCOSMICHead and Neck Cancer21798897
ENSP00000277541S402*COSMICHead and Neck Cancer21798897
ENSP00000277541R365CCOSMICHead and Neck Cancer21798897
ENSP00000277541G812WCOSMICHead and Neck Cancer21798897
ENSP00000277541E948*COSMICHead and Neck Cancer21798897
ENSP00000277541P391SCOSMICHead and Neck Cancer21798897
ENSP00000277541W1843*COSMICHead and Neck Cancer21798897
ENSP00000277541R1594QCOSMICSkin Cancer21984974
ENSP00000277541W861CBIOMARTBreast Cancer21930507, 21930502
ENSP00000277541G1339ACOSMICHead and Neck Cancer21798897
ENSP00000277541Q610*COSMICSkin Cancer21984974
ENSP00000277541R1279CCOSMICHead and Neck Cancer21798897
ENSP00000277541M2010RCOSMICHead and Neck Cancer21798897
ENSP00000277541R2327WCOSMICOvarian Cancer21720365
ENSP00000277541G310RCOSMICHead and Neck Cancer21798897
ENSP00000277541Q290*COSMICHead and Neck Cancer21798897
ENSP00000277541Q1957*COSMICHead and Neck Cancer21798897
ENSP00000277541P2417ACOSMICOvarian Cancer21720365
ENSP00000277541E450KCOSMICHead and Neck Cancer21798897
ENSP00000277541P1770SCOSMICSkin Cancer21984974
ENSP00000277541P668fs*104COSMICCentral Nervous System Neoplasms21817013
ENSP00000277541V1671IDing2008Lung Cancer18948947
ENSP00000277541P2271SCOSMICHead and Neck Cancer21798897
ENSP00000277541E424KCOSMICHead and Neck Cancer21798893
ENSP00000277541I377fs*254COSMICHead and Neck Cancer21798897
ENSP00000277541C456RCOSMICHead and Neck Cancer21798897
ENSP00000277541V2038LCOSMICHead and Neck Cancer21798897
ENSP00000277541P422SCOSMICHead and Neck Cancer21798893
ENSP00000277541C1554fs*26COSMICHead and Neck Cancer21798897
ENSP00000277541Q1214*COSMICHead and Neck Cancer21798893
ENSP00000277541Q1049LBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000277541G1637VCOSMICHead and Neck Cancer21798897
ENSP00000277541G481SCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000277541Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
NOTC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAG2_HUMANNOTC1_HUMANligand -> receptorHPMR
PLXA1_HUMANNOTC1_HUMANligand -> receptorHPMR
DLL1_HUMANNOTC1_HUMANligand -> receptorHPMR
DLL4_HUMANNOTC1_HUMANligand -> receptorHPMR
JAG1_HUMANNOTC1_HUMANligand -> receptorHPMR
OFUT1_HUMANNOTC1_HUMANglycosylationNetPath
LFNG_HUMANNOTC1_HUMANglycosylationNetPath
ADA17_HUMANNOTC1_HUMANcleavageNetPath
FURIN_HUMANNOTC1_HUMANcleavageNetPath
NUMB_HUMANNOTC1_HUMANotherKEGG
NOTC1_HUMANDTX2_HUMANotherKEGG
DVL1_HUMANNOTC1_HUMANotherKEGG
NOTC1_HUMANRBPJL_HUMANotherKEGG
LFNG_HUMANNOTC1_HUMANotherKEGG
JAG1_HUMANNOTC1_HUMANotherKEGG
ADA17_HUMANNOTC1_HUMANotherKEGG
DLL3_HUMANNOTC1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05020Prion diseases
hsa04320Dorso-ventral axis formation
hsa04330Notch signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003184pulmonary valve morphogenesisIMPbiological_process
GO:0004857enzyme inhibitor activityIEAmolecular_function
GO:0003209cardiac atrium morphogenesisISSbiological_process
GO:0003222ventricular trabecula myocardium morphogenesisISSbiological_process
GO:0060979vasculogenesis involved in coronary vascular morphIEAbiological_process
GO:0060548negative regulation of cell deathIEAbiological_process
GO:0003207cardiac chamber formationIEAbiological_process
GO:0002193MAML1-RBP-Jkappa- ICN1 complexIDAcellular_component
GO:0030513positive regulation of BMP signaling pathwayISSbiological_process
GO:0060317cardiac epithelial to mesenchymal transitionIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0001190RNA polymerase II transcription factor binding traISSmolecular_function
GO:0004872receptor activityIEAmolecular_function
GO:0045662negative regulation of myoblast differentiationIMPbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:0030216keratinocyte differentiationIEAbiological_process
GO:0060948cardiac vascular smooth muscle cell developmentIEAbiological_process
GO:0072044collecting duct developmentIEAbiological_process
GO:0003180aortic valve morphogenesisIMPbiological_process
GO:0030514negative regulation of BMP signaling pathwayISSbiological_process
GO:0008544epidermis developmentIEAbiological_process
GO:0045955negative regulation of calcium ion-dependent exocyIEAbiological_process
GO:2000974negative regulation of pro-B cell differentiationIEAbiological_process
GO:1901201regulation of extracellular matrix assemblyIEAbiological_process
GO:0050768negative regulation of neurogenesisIEAbiological_process
GO:0003209cardiac atrium morphogenesisIEAbiological_process
GO:0007507heart developmentIMPbiological_process
GO:0045668negative regulation of osteoblast differentiationIEAbiological_process
GO:0060843venous endothelial cell differentiationIEAbiological_process
GO:0014031mesenchymal cell developmentIEAbiological_process
GO:0003214cardiac left ventricle morphogenesisIEAbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0072017distal tubule developmentIEAbiological_process
GO:0003198epithelial to mesenchymal transition involved in eIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0030279negative regulation of ossificationIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0060411cardiac septum morphogenesisISSbiological_process
GO:0001047core promoter bindingISSmolecular_function
GO:0007492endoderm developmentIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0060740prostate gland epithelium morphogenesisIEAbiological_process
GO:0010001glial cell differentiationIEAbiological_process
GO:0003169coronary vein morphogenesisISSbiological_process
GO:0060253negative regulation of glial cell proliferationISSbiological_process
GO:0048715negative regulation of oligodendrocyte differentiaIEAbiological_process
GO:0007386compartment pattern specificationIEAbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0072602interleukin-4 secretionIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0010467gene expressionTASbiological_process
GO:0060045positive regulation of cardiac muscle cell prolifeIEAbiological_process
GO:0003256regulation of transcription from RNA polymerase IIISSbiological_process
GO:0003213cardiac right atrium morphogenesisISSbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0001190RNA polymerase II transcription factor binding traIEAmolecular_function
GO:0061384heart trabecula morphogenesisISSbiological_process
GO:0000122negative regulation of transcription from RNA polyISSbiological_process
GO:0005634nucleusISScellular_component
GO:0045668negative regulation of osteoblast differentiationISSbiological_process
GO:0007368determination of left/right symmetryIEAbiological_process
GO:0061419positive regulation of transcription from RNA polyISSbiological_process
GO:0001708cell fate specificationIEAbiological_process
GO:0009912auditory receptor cell fate commitmentIEAbiological_process
GO:0043086negative regulation of catalytic activityIEAbiological_process
GO:0003181atrioventricular valve morphogenesisIEAbiological_process
GO:0006955immune responseNASbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0001047core promoter bindingIEAmolecular_function
GO:0019899enzyme bindingIEAmolecular_function
GO:0003273cell migration involved in endocardial cushion forIEAbiological_process
GO:0003222ventricular trabecula myocardium morphogenesisIEAbiological_process
GO:0048715negative regulation of oligodendrocyte differentiaISSbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0060956endocardial cell differentiationIEAbiological_process
GO:0004857enzyme inhibitor activityISSmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0003162atrioventricular node developmentIEAbiological_process
GO:0050678regulation of epithelial cell proliferationIEAbiological_process
GO:0031069hair follicle morphogenesisIEAbiological_process
GO:0060956endocardial cell differentiationISSbiological_process
GO:0007221positive regulation of transcription of Notch receIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0001947heart loopingISSbiological_process
GO:0003203endocardial cushion morphogenesisISSbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0003160endocardium morphogenesisISSbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0048663neuron fate commitmentIEAbiological_process
GO:0001837epithelial to mesenchymal transitionISSbiological_process
GO:0007221positive regulation of transcription of Notch receISSbiological_process
GO:0030279negative regulation of ossificationISSbiological_process
GO:0003270Notch signaling pathway involved in regulation of IEAbiological_process
GO:0003241growth involved in heart morphogenesisIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0007440foregut morphogenesisIEAbiological_process
GO:0003160endocardium morphogenesisIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0060768regulation of epithelial cell proliferation involvIEAbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0042640anagenIEAbiological_process
GO:0003198epithelial to mesenchymal transition involved in eISSbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0010832negative regulation of myotube differentiationIEAbiological_process
GO:2000974negative regulation of pro-B cell differentiationISSbiological_process
GO:0070986left/right axis specificationIEAbiological_process
GO:0060038cardiac muscle cell proliferationIEAbiological_process
GO:2000811negative regulation of anoikisIMPbiological_process
GO:0003214cardiac left ventricle morphogenesisISSbiological_process
GO:0002040sprouting angiogenesisIEAbiological_process
GO:0050793regulation of developmental processIEAbiological_process
GO:0060843venous endothelial cell differentiationISSbiological_process
GO:0055008cardiac muscle tissue morphogenesisISSbiological_process
GO:0060842arterial endothelial cell differentiationIEAbiological_process
GO:0030514negative regulation of BMP signaling pathwayIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0003344pericardium morphogenesisIEAbiological_process
GO:0003169coronary vein morphogenesisIEAbiological_process
GO:0003208cardiac ventricle morphogenesisIEAbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0019899enzyme bindingISSmolecular_function
GO:0003181atrioventricular valve morphogenesisISSbiological_process
GO:0010718positive regulation of epithelial to mesenchymal tIMPbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0003157endocardium developmentIEAbiological_process
GO:0061314Notch signaling involved in heart developmentIEAbiological_process
GO:0046533negative regulation of photoreceptor cell differenIEAbiological_process
GO:0048711positive regulation of astrocyte differentiationIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0046427positive regulation of JAK-STAT cascadeISSbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0003208cardiac ventricle morphogenesisISSbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0001837epithelial to mesenchymal transitionIEAbiological_process
GO:0060842arterial endothelial cell differentiationISSbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0060412ventricular septum morphogenesisIMPbiological_process
GO:0003273cell migration involved in endocardial cushion forISSbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0014031mesenchymal cell developmentISSbiological_process
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0003241growth involved in heart morphogenesisISSbiological_process
GO:0030513positive regulation of BMP signaling pathwayIEAbiological_process
GO:0097150neuronal stem cell maintenanceIEPbiological_process
GO:0060045positive regulation of cardiac muscle cell prolifeISSbiological_process
GO:0060528secretory columnal luminar epithelial cell differeIEAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0003344pericardium morphogenesisISSbiological_process
GO:0071372cellular response to follicle-stimulating hormone IDAbiological_process
GO:0061314Notch signaling involved in heart developmentIMPbiological_process
GO:0060253negative regulation of glial cell proliferationIEAbiological_process
GO:0003207cardiac chamber formationISSbiological_process
GO:0031490chromatin DNA bindingIEAmolecular_function
GO:0010718positive regulation of epithelial to mesenchymal tIEAbiological_process
GO:0048103somatic stem cell divisionIEAbiological_process
GO:0030334regulation of cell migrationIEAbiological_process
GO:0055008cardiac muscle tissue morphogenesisIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:1901201regulation of extracellular matrix assemblyISSbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0045618positive regulation of keratinocyte differentiatioIEAbiological_process
GO:0035116embryonic hindlimb morphogenesisIEAbiological_process
GO:0046427positive regulation of JAK-STAT cascadeIEAbiological_process
GO:0016021integral to membraneNAScellular_component
GO:0030335positive regulation of cell migrationISSbiological_process
GO:0048711positive regulation of astrocyte differentiationISSbiological_process
GO:0003157endocardium developmentISSbiological_process
GO:0021915neural tube developmentIEAbiological_process
GO:0003219cardiac right ventricle formationIEAbiological_process
GO:0060982coronary artery morphogenesisIEAbiological_process
GO:0060411cardiac septum morphogenesisIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005576extracellular regionTAScellular_component
GO:0060979vasculogenesis involved in coronary vascular morphISSbiological_process
GO:0060982coronary artery morphogenesisISSbiological_process
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0003203endocardial cushion morphogenesisIEAbiological_process
GO:0002437inflammatory response to antigenic stimulusIEAbiological_process
GO:0060317cardiac epithelial to mesenchymal transitionISSbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0050767regulation of neurogenesisIEAbiological_process
GO:0003192mitral valve formationIMPbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0010812negative regulation of cell-substrate adhesionIDAbiological_process
GO:0007368determination of left/right symmetryISSbiological_process
GO:2000737negative regulation of stem cell differentiationIMPbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0003213cardiac right atrium morphogenesisIEAbiological_process
GO:0072144glomerular mesangial cell developmentIEAbiological_process
GO:0014807regulation of somitogenesisIEAbiological_process
GO:0050768negative regulation of neurogenesisISSbiological_process
GO:0060948cardiac vascular smooth muscle cell developmentISSbiological_process
GO:0043086negative regulation of catalytic activityISSbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0003256regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0006959humoral immune responseIEAbiological_process
GO:0061419positive regulation of transcription from RNA polyIEAbiological_process
GO:0061384heart trabecula morphogenesisIEAbiological_process
GO:0010832negative regulation of myotube differentiationISSbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0032495response to muramyl dipeptideIEAbiological_process