| UniProt/SwissProt ID: | RBPJL_HUMAN |
| Description: | recombination signal binding protein for immunoglobulin kappa J region-like [Source:HGNC Symbol;Acc:13761] |
| Location: | chr20 q13.12 |
| Node attribute: | PPI(target); TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T228 | SQTVStRYLSV | BTD | PhosphoSitePlus |
| T225 | RLRSQtVSTRY | BTD | PhosphoSitePlus |
| S227 | RSQTVsTRYLS | BTD | PhosphoSitePlus |
| S223 | FNRLRsQTVST | BTD | PhosphoSitePlus |
| Dephosphorylation site |
| RBPJL_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000341243 | C208F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000341243 | C208F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000341243 | A492T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000341243 | A299E | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000341243 | P429S | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| RBPJL_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RBPJL_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NOTC1_HUMAN | RBPJL_HUMAN | other | KEGG |
| HDAC1_HUMAN | RBPJL_HUMAN | other | KEGG |
| RBPJL_HUMAN | HES1_HUMAN | TF -> target gene | KEGG |
| RBPJL_HUMAN | PTCRA_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04330 | Notch signaling pathway |
| hsa05203 | Viral carcinogenesis |
| hsa05169 | Epstein-Barr virus infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region se | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0000982 | RNA polymerase II core promoter proximal region se | IEA | molecular_function |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |