Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DLL4_HUMAN
Description:delta-like 4 (Drosophila) [Source:HGNC Symbol;Acc:2910]
Location:chr15 q15.1
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S7AAASRsASGWAPhosphoSitePlus

Dephosphorylation site
DLL4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000249749K591NBIOMARTBreast Cancer21930507, 21930502
ENSP00000249749S471FCOSMICBreast Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000249749Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.3615169874

Hyperphosphorylation site
DLL4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DLL4_HUMANNOTC1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04330Notch signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIEAcellular_component
GO:0061314Notch signaling involved in heart developmentISSbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0072554blood vessel lumenizationIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0050767regulation of neurogenesisIEAbiological_process
GO:0003208cardiac ventricle morphogenesisIEAbiological_process
GO:0001525angiogenesisISSbiological_process
GO:0008015blood circulationTASbiological_process
GO:0001974blood vessel remodelingIEAbiological_process
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0001974blood vessel remodelingISSbiological_process
GO:0005112Notch bindingIEAmolecular_function
GO:0003344pericardium morphogenesisIEAbiological_process
GO:0043537negative regulation of blood vessel endothelial ceIEAbiological_process
GO:0035912dorsal aorta morphogenesisIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0003209cardiac atrium morphogenesisISSbiological_process
GO:0061314Notch signaling involved in heart developmentIEAbiological_process
GO:0035912dorsal aorta morphogenesisISSbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0003209cardiac atrium morphogenesisIEAbiological_process
GO:0003208cardiac ventricle morphogenesisISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0003222ventricular trabecula myocardium morphogenesisIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyISSbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0007154cell communicationIEAbiological_process
GO:0003222ventricular trabecula myocardium morphogenesisISSbiological_process
GO:0001569patterning of blood vesselsISSbiological_process
GO:0003344pericardium morphogenesisISSbiological_process


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