Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:JAG2_HUMAN
Description:jagged 2 [Source:HGNC Symbol;Acc:6189]
Location:chr14 q32.33
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S35FELQLsALRNVMNNLPhosphoSitePlus
Y203CDENYySATCNDSLPhosphoSitePlus
S1059TQRGNsSLLLAPhosphoSitePlus
S1060QRGNSsLLLAVPhosphoSitePlus
S1123LPREEsANNQWPhosphoSitePlus
T1155QCKNFtPPPRRPhosphoSitePlus
T1066LLLAVtEVKVEPhosphoSitePlus
Y202RCDENyYSATCDSLPhosphoSitePlus

Dephosphorylation site
JAG2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000328169R550LDing2008, COSMICLung Cancer18948947
ENSP00000328169G338CDing2008, COSMICLung Cancer18948947
ENSP00000328169D402NCOSMICBreast Cancer20668451
ENSP00000328169D592YCOSMICBreast Cancer20668451
ENSP00000328169Q1055*COSMICSkin Cancer21984974
ENSP00000328169D538NDing2008Lung Cancer18948947
ENSP00000328169D538NCOSMICSkin Cancer21984974

Differential expressed protein
JAG2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
JAG2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAG2_HUMANNOTC1_HUMANligand -> receptorHPMR
JAG2_HUMANNOTC3_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04330Notch signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030217T cell differentiationIDAbiological_process
GO:0009912auditory receptor cell fate commitmentIEAbiological_process
GO:0007219Notch signaling pathwayNASbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0042492gamma-delta T cell differentiationIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0007049cell cycleNASbiological_process
GO:0005112Notch bindingIPImolecular_function
GO:0001501skeletal system developmentIEAbiological_process
GO:0016331morphogenesis of embryonic epitheliumIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0042127regulation of cell proliferationIDAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0003016respiratory system processIEAbiological_process
GO:0008083growth factor activityIDAmolecular_function
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0009912auditory receptor cell fate commitmentISSbiological_process
GO:0045061thymic T cell selectionIDAbiological_process
GO:0030155regulation of cell adhesionIEAbiological_process
GO:0030154cell differentiationIDAbiological_process
GO:0007154cell communicationIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007220Notch receptor processingTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0007283spermatogenesisIEPbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0005887integral to plasma membraneISScellular_component
GO:0030334regulation of cell migrationNASbiological_process


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