Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNNT2_HUMAN
Description:troponin T type 2 (cardiac) [Source:HGNC Symbol;Acc:11949]
Location:chr1 q32.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S195KTERKsGKRQTMAP3K5HPRD
T291GKAKVtGRPRKCAHPRD
S205KTERKsGKRQTMAP3K5HPRD
S2MSDIEeVCK2_groupRegPhos
S2____MsDIEEVPhosphoSitePlus
T294GKAKVtGRWKPKCaRegPhos
S208QTERKsGKRQTMAP3K5RegPhos
Y197MHFGGyIQKQATroponinPhosphoSitePlus
T200SGKRQtEREKKPRKCAHPRD
T284GKAKVtGRPRKCAHPRD
T203SGKRQtEREKKPRKCAHPRD
T191GYIQKtERKSGMAP3K5HPRD
Y251LWQSIyNLEAETroponinPhosphoSitePlus
T213SGKRQtEREKKPKCaRegPhos
S198QTERKsGKRQTMAP3K5HPRD
T281GKAKVtGRPRKCAHPRD
T210SGKRQtEREKKPRKCAHPRD
T194QKQAQtERKSGMAP3K5HPRD
S208QTERKsGKRQTTroponinPhosphoSitePlus
T204QKQAQtERKSGMAP3K5RegPhos
T201GYIQKtERKSGMAP3K5HPRD

Dephosphorylation site
TNNT2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356287D227HBIOMARTBreast Cancer21930507, 21930502
ENSP00000356291D224HBIOMARTBreast Cancer21930507, 21930502
ENSP00000356284D224HBIOMARTBreast Cancer21930507, 21930502
ENSP00000422031D227HBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
TNNT2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S208TroponinQAQTERKsGKRQTERLVR; MI20418543PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
M3K5_HUMANTNNT2_HUMANkinase -> substrateRegPhos
KPCA_HUMANTNNT2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04260Cardiac muscle contraction
hsa05414Dilated cardiomyopathy

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006200ATP catabolic processIDAbiological_process
GO:0032780negative regulation of ATPase activityIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0055009atrial cardiac muscle tissue morphogenesisIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0051592response to calcium ionIMPbiological_process
GO:0005861troponin complexIDAcellular_component
GO:0045214sarcomere organizationIEAbiological_process
GO:0005861troponin complexIEAcellular_component
GO:0005523tropomyosin bindingIDAmolecular_function
GO:0003779actin bindingIDAmolecular_function
GO:0030016myofibrilIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0030017sarcomereTAScellular_component
GO:0030017sarcomereIEAcellular_component
GO:0005865striated muscle thin filamentIDAcellular_component
GO:0055010ventricular cardiac muscle tissue morphogenesisIEAbiological_process
GO:0016887ATPase activityIDAmolecular_function
GO:0005200structural constituent of cytoskeletonIEAmolecular_function
GO:0032781positive regulation of ATPase activityIDAbiological_process
GO:0008016regulation of heart contractionIEAbiological_process
GO:0030049muscle filament slidingIDAbiological_process
GO:0055010ventricular cardiac muscle tissue morphogenesisIMPbiological_process
GO:0031013troponin I bindingIPImolecular_function
GO:0006936muscle contractionIEAbiological_process
GO:0030172troponin C bindingIPImolecular_function
GO:0008016regulation of heart contractionIMPbiological_process