| UniProt/SwissProt ID: | M3K5_HUMAN |
| Description: | mitogen-activated protein kinase kinase kinase 5 [Source:HGNC Symbol;Acc:6857] |
| Location: | chr6 q23.3 |
| Node attribute: | ubiquitination(target); substrate; kinase; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S83 | RGRGSsVGGGS | AKT_group | RegPhos |
| S964 | NEYLRsISLPV | PhosphoSitePlus | |
| S83 | RGRGSsVGGGS | AKT1 | HPRD; RegPhos |
| S1033 | HSAPPsPEEKD | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S83 | RGRGSsVGGGS | Akt2(PKB beta | RegPhos |
| S1029 | NFEDHsAPPSP | PhosphoSitePlus; HPRD; phosphoELM | |
| Y574 | IYQPSyLSINN | PhosphoSitePlus | |
| Y814 | VLINTySGVLK | Pkinase | PhosphoSitePlus |
| T813 | NVLINtYSGVL | Pkinase | PhosphoSitePlus |
| S1240 | QSAHRsLNVQL | PhosphoSitePlus | |
| T842 | ETFTGtLQYMA | HPRD; RegPhos | |
| S966 | YLRSIsLPVPV | MAP3K5 | phosphoELM; RegPhos |
| Y718 | ERDSRySQPLH | Pkinase | PhosphoSitePlus |
| Y982 | SSSSEyGSVSP | PhosphoSitePlus | |
| T842 | ETFTGtLQYMA | Pkinase | PhosphoSitePlus |
| T838 | NPCTEtFTGTL | MAP3K5 | HPRD; RegPhos |
| S83 | RGRGSsVGGGS | PhosphoSitePlus | |
| S986 | EYGSVsPDTEL | PhosphoSitePlus | |
| T838 | NPCTEtFTGTL | PDK1 | RegPhos |
| T838 | NPCTEtFTGTL | PDK-1 | phosphoELM |
| S966 | YLRSIsLPVPV | PhosphoSitePlus; HPRD; RegPhos | |
| S958 | ALSAGsNEYLR | PhosphoSitePlus; RegPhos | |
| T838 | NPCTEtFTGTL | phosphoELM; RegPhos | |
| S83 | RGRGSsVGGGS | PKB_group | phosphoELM |
| S461 | GVKLSsLLGKK | DUF4071 | PhosphoSitePlus |
| T838 | NPCTEtFTGTL | Pkinase | PhosphoSitePlus |
| S83 | RGRGSsVGGGS | PKB_beta | phosphoELM |
| T528 | HFVKLtTEQPV | DUF4071 | PhosphoSitePlus |
| Y570 | EPTKIyQPSYL | PhosphoSitePlus | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T842 | CTETFTGtLQYMAPE | PPP5C | HPRD |
| Mutation site |
| M3K5_HUMAN do not have mutation site. |
| Differential expressed protein |
| M3K5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| M3K5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| M3K5_HUMAN | MP2K4_HUMAN | kinase -> substrate | RegPhos |
| M3K5_HUMAN | MP2K6_HUMAN | kinase -> substrate | KEGG |
| AKT3_HUMAN | M3K5_HUMAN | kinase -> substrate | KEGG |
| M3K5_HUMAN | M3K5_HUMAN | kinase -> substrate | RegPhos |
| AKT1_HUMAN | M3K5_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | M3K5_HUMAN | kinase -> substrate | RegPhos |
| PDPK1_HUMAN | M3K5_HUMAN | kinase -> substrate | RegPhos |
| M3K5_HUMAN | TNNT2_HUMAN | kinase -> substrate | RegPhos |
| FAK2_HUMAN | M3K5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K5_HUMAN | MP2K3_HUMAN | kinase -> substrate | KEGG |
| PPP5_HUMAN | M3K5_HUMAN | phosphatase -> substrate | HPRD; KEGG |
| BIRC2_HUMAN | M3K5_HUMAN | ubiquitination | NetPath |
| DAXX_HUMAN | M3K5_HUMAN | other | KEGG |
| TRAF2_HUMAN | M3K5_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| hsa04722 | Neurotrophin signaling pathway |
| hsa04010 | MAPK signaling pathway |
| hsa04141 | Protein processing in endoplasmic reticulum |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008631 | intrinsic apoptotic signaling pathway in response | IDA | biological_process |
| GO:0097190 | apoptotic signaling pathway | TAS | biological_process |
| GO:0000187 | activation of MAPK activity | IEA | biological_process |
| GO:0010941 | regulation of cell death | IEA | biological_process |
| GO:0043065 | positive regulation of apoptotic process | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0008656 | cysteine-type endopeptidase activator activity inv | IDA | molecular_function |
| GO:0005783 | endoplasmic reticulum | IEA | cellular_component |
| GO:0045087 | innate immune response | IEA | biological_process |
| GO:0007254 | JNK cascade | IDA | biological_process |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0000165 | MAPK cascade | IDA | biological_process |
| GO:0070301 | cellular response to hydrogen peroxide | IDA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0007257 | activation of JUN kinase activity | TAS | biological_process |
| GO:0000287 | magnesium ion binding | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0042803 | protein homodimerization activity | IDA | molecular_function |
| GO:0043280 | positive regulation of cysteine-type endopeptidase | IDA | biological_process |
| GO:0006919 | activation of cysteine-type endopeptidase activity | IDA | biological_process |
| GO:0004672 | protein kinase activity | IDA | molecular_function |
| GO:0019903 | protein phosphatase binding | IPI | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0010421 | hydrogen peroxide-mediated programmed cell death | IDA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IEA | molecular_function |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0000186 | activation of MAPKK activity | IDA | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |