UniProt/SwissProt ID: | LSHR_HUMAN |
Description: | luteinizing hormone/choriogonadotropin receptor [Source:HGNC Symbol;Acc:6585] |
Location: | chr2 p16.3 |
Node attribute: | GPCR; receptor; PPI(target) |
Phosphorylation site |
LSHR_HUMAN do not have phosphorylation site. |
Dephosphorylation site |
LSHR_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000294954 | P597H | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000294954 | D578H | HPI | Testicular Cancer | 10580072 21490077 17045393 16918965 15539429 12356766 12447668 11857565 11356670 |
ENSP00000294954 | T467I | COSMIC | Melanoma | 21499247 |
ENSP00000294954 | R554* | COSMIC | Lung Cancer | 20668451 |
ENSP00000294954 | D564N | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 |
ENSP00000294954 | S387I | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000294954 | A583T | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
ENSP00000294954 | I573N | COSMIC | Breast Cancer | 20668451 |
ENSP00000294954 | M582T | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000294954 | I528T | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000294954 | E463G | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000294954 | T272M | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
ENSP00000294954 | S616F | COSMIC | Skin Cancer | 21984974 |
ENSP00000294954 | D405N | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000294954 | L650H | COSMIC | Lung Cancer | 20668451 |
ENSP00000294954 | E323K | COSMIC | Head and Neck Cancer | 21798893 |
ENSP00000294954 | R219H | COSMIC | Head and Neck Cancer | 21798893 |
ENSP00000294954 | E206K | COSMIC | Skin Cancer | 21984974 |
Differential expressed protein |
LSHR_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
LSHR_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
LSHB_HUMAN | LSHR_HUMAN | ligand -> receptor | HPMR |
GLHA_HUMAN | LSHR_HUMAN | ligand -> receptor | HPMR |
CGHB_HUMAN | LSHR_HUMAN | ligand -> receptor | HPMR |
LSHR_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
LSHR_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
LSHR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
LSHR_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
LSHR_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
LSHR_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
LSHR_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
LSHR_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
GLHA_HUMAN | LSHR_HUMAN | other | KEGG |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04080 | Neuroactive ligand-receptor interaction |
hsa04020 | Calcium signaling pathway |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0005887 | integral to plasma membrane | ISS | cellular_component |
GO:0046544 | development of secondary male sexual characteristi | IEA | biological_process |
GO:0008584 | male gonad development | IEA | biological_process |
GO:0038106 | choriogonadotropin hormone binding | IEA | molecular_function |
GO:0071371 | cellular response to gonadotropin stimulus | IEA | biological_process |
GO:0071371 | cellular response to gonadotropin stimulus | ISS | biological_process |
GO:0008584 | male gonad development | TAS | biological_process |
GO:0005887 | integral to plasma membrane | IEA | cellular_component |
GO:0007190 | activation of adenylate cyclase activity | ISS | biological_process |
GO:0030539 | male genitalia development | TAS | biological_process |
GO:0035472 | choriogonadotropin hormone receptor activity | IEA | molecular_function |
GO:0005886 | plasma membrane | TAS | cellular_component |
GO:0022602 | ovulation cycle process | IEA | biological_process |
GO:0005768 | endosome | TAS | cellular_component |
GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
GO:0007200 | phospholipase C-activating G-protein coupled recep | IEA | biological_process |
GO:0072520 | seminiferous tubule development | IEA | biological_process |
GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
GO:0007200 | phospholipase C-activating G-protein coupled recep | ISS | biological_process |
GO:0038106 | choriogonadotropin hormone binding | ISS | molecular_function |
GO:0016021 | integral to membrane | IEA | cellular_component |
GO:0001541 | ovarian follicle development | IEA | biological_process |
GO:0060065 | uterus development | IEA | biological_process |
GO:0008585 | female gonad development | IEA | biological_process |
GO:0043950 | positive regulation of cAMP-mediated signaling | ISS | biological_process |
GO:0090030 | regulation of steroid hormone biosynthetic process | IEA | biological_process |
GO:0007190 | activation of adenylate cyclase activity | IEA | biological_process |
GO:0007283 | spermatogenesis | IEA | biological_process |
GO:0032962 | positive regulation of inositol trisphosphate bios | ISS | biological_process |
GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
GO:0035472 | choriogonadotropin hormone receptor activity | ISS | molecular_function |
GO:0004964 | luteinizing hormone receptor activity | IEA | molecular_function |
GO:0043950 | positive regulation of cAMP-mediated signaling | IEA | biological_process |
GO:0032962 | positive regulation of inositol trisphosphate bios | IEA | biological_process |