Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRF8_HUMAN
Description:interferon regulatory factor 8 [Source:HGNC Symbol;Acc:5358]
Location:chr16 q24.1
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y110EPYKVyRIVPEIRFPhosphoSitePlus
Y373QIEQLyVRQLAIRF-3PhosphoSitePlus
Y107DISEPyKVYRIIRFPhosphoSitePlus

Dephosphorylation site
IRF8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000268638R81KSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000268638K148RCOSMICOvarian Cancer21720365
ENSP00000268638R37WCOSMICOvarian Cancer21720365
ENSP00000268638A197TSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000268638K148RTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
IRF8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IRF8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IRF8_HUMANISG15_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
IRF8_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006955immune responseIEAbiological_process
GO:0032735positive regulation of interleukin-12 productionIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0009617response to bacteriumIEAbiological_process
GO:0044130negative regulation of growth of symbiont in hostIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiTASmolecular_function
GO:0000122negative regulation of transcription from RNA polyTASbiological_process
GO:0006909phagocytosisIEAbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0042832defense response to protozoanIEAbiological_process
GO:0000975regulatory region DNA bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0030099myeloid cell differentiationIEAbiological_process
GO:0042742defense response to bacteriumIEAbiological_process
GO:0032729positive regulation of interferon-gamma productionIEAbiological_process
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23