Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ISG15_HUMAN
Description:ISG15 ubiquitin-like modifier [Source:HGNC Symbol;Acc:4053]
Location:chr1 p36.33
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S26SSMSVsELKAQHPRD

Dephosphorylation site
ISG15_HUMAN do not have dephosphorylation site.

Mutation site
ISG15_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000368699Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3518646787
ENSP00000368699Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.04518646787
ENSP00000368699Oral CancerNormal vs. CancertissueUp2119297561
ENSP00000368699Breast CancerNormal vs. CancertissueUp0.4420739354

Hyperphosphorylation site
ISG15_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IRF7_HUMANISG15_HUMANTF -> target geneTRANSFAC
IRF3_HUMANISG15_HUMANTF -> target geneTRANSFAC
IRF1_HUMANISG15_HUMANTF -> target geneTRANSFAC
IRF4_HUMANISG15_HUMANTF -> target geneTRANSFAC
SPI1_HUMANISG15_HUMANTF -> target geneTRANSFAC
IRF8_HUMANISG15_HUMANTF -> target geneTRANSFAC
IRF9_HUMANISG15_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ISG15_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005615extracellular spaceNAScellular_component
GO:0019941modification-dependent protein catabolic processIEAbiological_process
GO:0032020ISG15-protein conjugationIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0032480negative regulation of type I interferon productioTASbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0031386protein tagIEAmolecular_function
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0005737cytoplasmNAScellular_component
GO:0007267cell-cell signalingNASbiological_process
GO:0032020ISG15-protein conjugationIDAbiological_process


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