Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FOXA2_HUMAN
Description:forkhead box A2 [Source:HGNC Symbol;Acc:5022]
Location:chr20 p11.21
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S111LSPSLsPLGGQFork_head_NPhosphoSitePlus
T156YRRSYtHAKPPFork_head_NPhosphoSitePlus
S107MGPHLsPSLSPFork_head_NPhosphoSitePlus
Y248FENGCyLRRQKFork_headPhosphoSitePlus

Dephosphorylation site
FOXA2_HUMAN do not have dephosphorylation site.

Mutation site
FOXA2_HUMAN do not have mutation site.

Differential expressed protein
FOXA2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S111Fork_head_NPHLSPSLsPLGGQAAhepatocellular carcinoma22196886PhosphoSitePlus
S107Fork_head_NAGMGPHLsPSLSPLGhepatocellular carcinoma22196886PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
FOXA2_HUMANPDX1_HUMANTF -> target geneTRANSFAC
FOXA2_HUMANTHRB_HUMANTF -> target geneTRANSFAC
FOXA2_HUMANIBP1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
FOXA2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0019904protein domain specific bindingIBAmolecular_function
GO:0048665neuron fate specificationIEAbiological_process
GO:0060487lung epithelial cell differentiationIEAbiological_process
GO:0044464cell partIEAcellular_component
GO:2000543positive regulation of gastrulationIEAbiological_process
GO:0090009primitive streak formationIEAbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIMPbiological_process
GO:0021533cell differentiation in hindbrainIEAbiological_process
GO:0008134transcription factor bindingIBAmolecular_function
GO:0033132negative regulation of glucokinase activityIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0001705ectoderm formationIBAbiological_process
GO:0000433negative regulation of transcription from RNA polyISSbiological_process
GO:2000976regulation of transcription from RNA polymerase IIISSbiological_process
GO:2000049positive regulation of cell-cell adhesion mediatedICbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0000432positive regulation of transcription from RNA polyIEAbiological_process
GO:0051090regulation of sequence-specific DNA binding transcIBAbiological_process
GO:0007492endoderm developmentIBAbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0032289central nervous system myelin formationIBAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0048468cell developmentIEAbiological_process
GO:2000976regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0031018endocrine pancreas developmentIEAbiological_process
GO:0060487lung epithelial cell differentiationIBAbiological_process
GO:0000432positive regulation of transcription from RNA polyISSbiological_process
GO:0045945positive regulation of transcription from RNA polyIEAbiological_process
GO:0021904dorsal/ventral neural tube patterningIEAbiological_process
GO:0060441epithelial tube branching involved in lung morphogIBAbiological_process
GO:0033132negative regulation of glucokinase activityISSbiological_process
GO:0061178regulation of insulin secretion involved in cellulISSbiological_process
GO:0021904dorsal/ventral neural tube patterningIBAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:2000543positive regulation of gastrulationISSbiological_process
GO:0044212transcription regulatory region DNA bindingIMPmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0001701in utero embryonic developmentIBAbiological_process
GO:0045665negative regulation of neuron differentiationIBAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIBAmolecular_function
GO:0005667transcription factor complexIBAcellular_component
GO:0021533cell differentiation in hindbrainIBAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0000978RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0021779oligodendrocyte cell fate commitmentIBAbiological_process
GO:0009952anterior/posterior pattern specificationIBAbiological_process
GO:0030193regulation of blood coagulationIDAbiological_process
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0032525somite rostral/caudal axis specificationIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0003690double-stranded DNA bindingIBAmolecular_function
GO:0023019signal transduction involved in regulation of geneIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0001708cell fate specificationIEAbiological_process
GO:0000433negative regulation of transcription from RNA polyIEAbiological_process
GO:0010719negative regulation of epithelial to mesenchymal tIMPbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0048646anatomical structure formation involved in morphogIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0090009primitive streak formationISSbiological_process
GO:2000971negative regulation of detection of glucoseIEAbiological_process
GO:0045666positive regulation of neuron differentiationIBAbiological_process
GO:0061178regulation of insulin secretion involved in cellulIEAbiological_process
GO:0040019positive regulation of embryonic developmentISSbiological_process
GO:0070741response to interleukin-6TASbiological_process
GO:0040019positive regulation of embryonic developmentIEAbiological_process
GO:0048665neuron fate specificationIBAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0060441epithelial tube branching involved in lung morphogIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0001705ectoderm formationIEAbiological_process
GO:0031018endocrine pancreas developmentIBAbiological_process
GO:0016568chromatin modificationIEAbiological_process
GO:0009953dorsal/ventral pattern formationIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0071542dopaminergic neuron differentiationIEAbiological_process
GO:0008344adult locomotory behaviorIEAbiological_process
GO:0009653anatomical structure morphogenesisIEAbiological_process
GO:2000971negative regulation of detection of glucoseISSbiological_process
GO:0003677DNA bindingIEAmolecular_function