Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GAB2_HUMAN
Description:GRB2-associated binding protein 2 [Source:HGNC Symbol;Acc:14458]
Location:chr11 q14.1
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T408ASSCEtYEYPQPhosphoSitePlus
S133LRNVSsAGHGPAbi_CPhosphoSitePlus
S480VYIPMsPGAHHPhosphoSitePlus
T385RSVAAtIPRRNPhosphoSitePlus; HPRD
S148AELSSsSQHLLHPRD
S223SFLMRsDTAVQPhosphoSitePlus
S623DFQPSsPSPHRMAPK1HPRD
S550ITKSWsRANHTPhosphoSitePlus; SysPTM
S623DFQPSsPSPHRPhosphoSitePlus
Y249QVHGFySLPKPPhosphoSitePlus
Y293DNEDVyTFKTPPhosphoSitePlus; phosphoELM; RegPhos
T391IPRRNtLPAMDPhosphoSitePlus
S543ELPFKsPITKSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S625QPSSPsPHRKPPhosphoSitePlus
S631PHRKPsTSSVTPhosphoSitePlus
T636STSSVtSDEKVPhosphoSitePlus
Y643DEKVDyVQVDKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y324TPLSAyQIPRTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y476NSQSVyIPMSPPhosphoSitePlus; phosphoELM; RegPhos
S164SAPSHsSQPTLPhosphoSitePlus
Y411CETYEyPQRGGPhosphoSitePlus
Y614TGSVDyLALDFZAP70HPRD; phosphoELM; RegPhos
Y409SSCETyEYPQRPhosphoSitePlus
S149ELSSSsQHLLRAbi_CPhosphoSitePlus
Y614TGSVDyLALDFPhosphoSitePlus
S210NARSAsFSQGTPhosphoSitePlus
S140GHGPRsSPAELHPRD; phosphoELM
S141HGPRSsPAELSAbi_CPhosphoSitePlus
S488AHHFDsLGYPSPhosphoSitePlus
T278ASHGHtKGSLTPhosphoSitePlus
Y194PQEYLyLHQCIPhosphoSitePlus
Y491FDSLGyPSTTLPhosphoSitePlus
Y48PDVLEyYKNDHPHPhosphoSitePlus
Y584DSEENyVPMQNPhosphoSitePlus; phosphoELM; RegPhos
S622LDFQPsSPSPHPhosphoSitePlus
T294NEDVYtFKTPSPhosphoSitePlus
S159RERKSsAPSHSPKB_groupphosphoELM
S623DFQPSsPSPHRErk1(MAPK3RegPhos
Y266FRDSTyDLPRSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S218QGTRAsFLMRSPhosphoSitePlus
S159RERKSsAPSHSAKT1HPRD; RegPhos
S322PATPLsAYQIPPhosphoSitePlus
S637TSSVTsDEKVDPhosphoSitePlus
T265EFRDStYDLPRPhosphoSitePlus; RegPhos
S623DFQPSsPSPHRMAPK3HPRD; phosphoELM
S623DFQPSsPSPHRErk1RegPhos
S623DFQPSsPSPHRErk2RegPhos
S448SDSTNsEDNYVPhosphoSitePlus
S281GHTKGsLTGSEPhosphoSitePlus
S148AELSSsSQHLLAbi_CPhosphoSitePlus
S611KKSTGsVDYLAPhosphoSitePlus
S159RERKSsAPSHSAKT_groupRegPhos
T331IPRTFtLDKNHPhosphoSitePlus
S159RERKSsAPSHSPhosphoSitePlus
Y452NSEDNyVPMNPPhosphoSitePlus; phosphoELM; RegPhos
S250VHGFYsLPKPSPhosphoSitePlus
Y49DVLEYyKNDHSPHPhosphoSitePlus
S474GDNSQsVYIPMPhosphoSitePlus
S472RAGDNsQSVYIPhosphoSitePlus
T287LTGSEtDNEDVPhosphoSitePlus
S405LHRASsCETYEPhosphoSitePlus; RegPhos
S140GHGPRsSPAELAbi_CPhosphoSitePlus
Y563SSSSQyCRPISPhosphoSitePlus
T171QPTLFtFEPPVPhosphoSitePlus
S404RLHRAsSCETYPhosphoSitePlus; HPRD
S264TEFRDsTYDLPPhosphoSitePlus; RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y643TSDEKVDyVQVDKEKPTPN11HPRD
Y643TSDEKVDyVQVDKEKPTPN6HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354952D444YCOSMICHead and Neck Cancer21798893
ENSP00000354952P161LCOSMICLung Cancer
ENSP00000354952T331NCOSMICOvarian Cancer21720365
ENSP00000354952S503RCOSMICOvarian Cancer21720365
ENSP00000354952D520NCOSMICOvarian Cancer21720365
ENSP00000354952H277YCOSMICOvarian Cancer21720365
ENSP00000354952V341MCOSMICSkin Cancer21984974

Differential expressed protein
GAB2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GAB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LYN_HUMANGAB2_HUMANkinase -> substrateNetPath
MK03_HUMANGAB2_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
MK01_HUMANGAB2_HUMANkinase -> substrateHPRD; NetPath
FYN_HUMANGAB2_HUMANkinase -> substrateKEGG
AKT1_HUMANGAB2_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANGAB2_HUMANkinase -> substrateRegPhos
KSYK_HUMANGAB2_HUMANkinase -> substrateNetPath
LCK_HUMANGAB2_HUMANkinase -> substrateNetPath
ZAP70_HUMANGAB2_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
PTN6_HUMANGAB2_HUMANphosphatase -> substrateHPRD
PTN11_HUMANGAB2_HUMANphosphatase -> substrateHPRD
KSYK_HUMANGAB2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05220Chronic myeloid leukemia
hsa04666Fc gamma R-mediated phagocytosis
hsa04380Osteoclast differentiation
hsa04664Fc epsilon RI signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030316osteoclast differentiationIMPbiological_process
GO:0043325phosphatidylinositol-3,4-bisphosphate bindingISSmolecular_function
GO:0005070SH3/SH2 adaptor activityRCAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005068transmembrane receptor protein tyrosine kinase adaIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005829cytosolTAScellular_component
GO:0048015phosphatidylinositol-mediated signalingISSbiological_process
GO:0005547phosphatidylinositol-3,4,5-trisphosphate bindingISSmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIDAbiological_process
GO:0043306positive regulation of mast cell degranulationISSbiological_process


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