Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:THOC1_HUMAN
Description:THO complex 1 [Source:HGNC Symbol;Acc:19070]
Location:chr18 p11.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T4PLFSHPRD
T439GNEELtRLWNLefThoc1PhosphoSitePlus
S2TPPLHPRD; phosphoELM; SysPTM
S315LQLSDsNFRRHefThoc1PhosphoSitePlus
S2____MsPTPPLPhosphoSitePlus; SysPTM
S560LKENEsPDVRRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T439GNEELtRLWNLHPRD
S313MDLQLsDSNFRefThoc1PhosphoSitePlus
Y274AVFKSyKLDDTefThoc1PhosphoSitePlus
S657DNETHPRD
T542SEEIKtGEDEDPhosphoSitePlus
T428LGKGPtKKILMefThoc1PhosphoSitePlus

Dephosphorylation site
THOC1_HUMAN do not have dephosphorylation site.

Mutation site
THOC1_HUMAN do not have mutation site.

Differential expressed protein
THOC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
THOC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FRK_HUMANTHOC1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
THOC1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016363nuclear matrixIEAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0000445THO complex part of transcription export complexIDAcellular_component
GO:0006406mRNA export from nucleusIDAbiological_process
GO:0006396RNA processingTASbiological_process
GO:0008380RNA splicingIEAbiological_process
GO:0006915apoptotic processIDAbiological_process
GO:0000346transcription export complexIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0046784intronless viral mRNA export from host nucleusIDAbiological_process
GO:0000347THO complexIDAcellular_component
GO:0003723RNA bindingIEAmolecular_function
GO:0006397mRNA processingIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0032784regulation of DNA-dependent transcription, elongatIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0016607nuclear speckIEAcellular_component


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