| UniProt/SwissProt ID: | COMT_HUMAN |
| Description: | catechol-O-methyltransferase [Source:HGNC Symbol;Acc:2228] |
| Location: | chr22 q11.21 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y82 | EAIDTyCEQKE | Methyltransf_3 | PhosphoSitePlus |
| Y180 | QLKKKyDVDTL | HPRD | |
| S131 | MARLLsPGARL | Methyltransf_3 | PhosphoSitePlus |
| Y130 | QLKKKyDVDTL | HPRD | |
| Y262 | LEKAIyKGPGS | PhosphoSitePlus | |
| Y244 | FECTHyQSFLE | PhosphoSitePlus | |
| Y180 | QLKKKyDVDTL | Methyltransf_3 | PhosphoSitePlus |
| T81 | LEAIDtYCEQK | Methyltransf_3 | PhosphoSitePlus |
| Dephosphorylation site |
| COMT_HUMAN do not have dephosphorylation site. |
| Mutation site |
| COMT_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000385150 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 11 | 18646787 | ENSP00000385150 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 3 | 18646787 | ENSP00000385150 | Gastric Cancer | Metastasis | cell line | Up | 1.4 | 17022644 | ENSP00000385150 | colorectal cancer | Normal vs. Cancer | tissue | Up | 1.5 | 19098285 | ENSP00000385150 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 0.26 | 15759316 | ENSP00000385150 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 0.34 | 17627933 | ENSP00000385150 | Breast Cancer | Treatment (Antiestrogen-sensitive vs. Antiestrogen-resistant) | cell line | Up | 1.5 | 14557597 | ENSP00000385150 | hepatitis C virus | Normal vs. Cancer | tissue | Down | 0.1 | 16097030 | ENSP00000385150 | Gastric Cancer | Metastasis | cell line | Up | 1.4 | 17022644 | ENSP00000385150 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.46 | 20739354 | ENSP00000385150 | Renal Cancer | Normal vs. Cancer | tissue | Up | 2.8 | 19610612 | ENSP00000385150 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 |
| Hyperphosphorylation site |
| COMT_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| COMT_HUMAN | DRD3_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa01100 | Metabolic pathways |
| hsa00350 | Tyrosine metabolism |
| hsa00140 | Steroid hormone biosynthesis |
| hsa04728 | Dopaminergic synapse |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042135 | neurotransmitter catabolic process | IEA | biological_process |
| GO:0008210 | estrogen metabolic process | IEA | biological_process |
| GO:0007565 | female pregnancy | IEA | biological_process |
| GO:0042136 | neurotransmitter biosynthetic process | TAS | biological_process |
| GO:0048662 | negative regulation of smooth muscle cell prolifer | IEA | biological_process |
| GO:0048609 | multicellular organismal reproductive process | IEA | biological_process |
| GO:0007612 | learning | IEA | biological_process |
| GO:0032259 | methylation | TAS | biological_process |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0016206 | catechol O-methyltransferase activity | IEA | molecular_function |
| GO:0009712 | catechol-containing compound metabolic process | IEA | biological_process |
| GO:0042493 | response to drug | IEA | biological_process |
| GO:0045963 | negative regulation of dopamine metabolic process | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0006584 | catecholamine metabolic process | IEA | biological_process |
| GO:0050668 | positive regulation of homocysteine metabolic proc | IEA | biological_process |
| GO:0032496 | response to lipopolysaccharide | IEA | biological_process |
| GO:0042420 | dopamine catabolic process | IEA | biological_process |
| GO:0048265 | response to pain | IEA | biological_process |
| GO:0014070 | response to organic cyclic compound | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0042417 | dopamine metabolic process | IEA | biological_process |
| GO:0008171 | O-methyltransferase activity | TAS | molecular_function |
| GO:0006805 | xenobiotic metabolic process | TAS | biological_process |
| GO:0000287 | magnesium ion binding | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |