| UniProt/SwissProt ID: | CTLA4_HUMAN |
| Description: | cytotoxic T-lymphocyte-associated protein 4 [Source:HGNC Symbol;Acc:2505] |
| Location: | chr2 q33.2 |
| Node attribute: | substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y201 | LTTGVyVKMPP | TXK | HPRD; phosphoELM; RegPhos |
| Y201 | LTTGVyVKMPP | FYN | HPRD; RegPhos |
| Y218 | KQFQPyFIPIN | PhosphoSitePlus | |
| Y201 | LTTGVyVKMPP | PhosphoSitePlus | |
| Y201 | LTTGVyVKMPP | JAK2 | HPRD; phosphoELM; RegPhos |
| Y201 | LTTGVyVKMPP | LCK | HPRD; RegPhos |
| Dephosphorylation site |
| CTLA4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CTLA4_HUMAN do not have mutation site. |
| Differential expressed protein |
| CTLA4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CTLA4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| JAK2_HUMAN | CTLA4_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| LCK_HUMAN | CTLA4_HUMAN | kinase -> substrate | HPRD; RegPhos; NetPath |
| FYN_HUMAN | CTLA4_HUMAN | kinase -> substrate | HPRD; RegPhos; NetPath |
| TXK_HUMAN | CTLA4_HUMAN | kinase -> substrate | HPRD; RegPhos |
| CD86_HUMAN | CTLA4_HUMAN | other | KEGG |
| CD80_HUMAN | CTLA4_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa05320 | Autoimmune thyroid disease |
| hsa05323 | Rheumatoid arthritis |
| hsa04660 | T cell receptor signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006955 | immune response | IEA | biological_process |
| GO:0045590 | negative regulation of regulatory T cell different | IDA | biological_process |
| GO:0050853 | B cell receptor signaling pathway | IMP | biological_process |
| GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0045334 | clathrin-coated endocytic vesicle | IDA | cellular_component |
| GO:0006974 | response to DNA damage stimulus | IMP | biological_process |
| GO:0009897 | external side of plasma membrane | IDA | cellular_component |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0043065 | positive regulation of apoptotic process | IMP | biological_process |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030889 | negative regulation of B cell proliferation | IMP | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |