Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CRY1_HUMAN
Description:cryptochrome 1 (photolyase-like) [Source:HGNC Symbol;Acc:2384]
Location:chr12 q23.3
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y432DYIRRyLPVLRphosphoELM
S568GGKRPsQEEDTPhosphoSitePlus
Y494QQLSRyRGLGLHPRD
Y432DYIRRyLPVLRFAD_binding_7PhosphoSitePlus
S492IYQQLsRYRGLPhosphoSitePlus

Dephosphorylation site
CRY1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000008527D307HBIOMARTBreast Cancer21930507, 21930502
ENSP00000008527D201NCOSMICOvarian Cancer21720365
ENSP00000008527K228NCOSMICOvarian Cancer21720365

Differential expressed protein
CRY1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CRY1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK4_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
STK36_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
M3K8_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
FASTK_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
MYLK2_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
BMR1B_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
CRY1_HUMANCRY1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04710Circadian rhythm - mammal

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003913DNA photolyase activityIEAmolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0042752regulation of circadian rhythmIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0018298protein-chromophore linkageIEAbiological_process
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0003677DNA bindingTASmolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0007623circadian rhythmIEAbiological_process
GO:0009785blue light signaling pathwayNASbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0019902phosphatase bindingIPImolecular_function
GO:0000988protein binding transcription factor activityIDAmolecular_function
GO:0009882blue light photoreceptor activityNASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process


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