| UniProt/SwissProt ID: | CD28_HUMAN |
| Description: | CD28 molecule [Source:HGNC Symbol;Acc:1653] |
| Location: | chr2 q33.2 |
| Node attribute: | PPI(target); substrate; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y218 | RDFAAy | phosphoELM | |
| Y218 | RDFAAyRS | ITK | RegPhos |
| Y191 | LLHSDyMNMTP | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y191 | LLHSDyMNMTP | ITK | HPRD; phosphoELM; RegPhos |
| T195 | DYMNMtPRRPG | PhosphoSitePlus | |
| Y218 | RDFAAy | ITK | HPRD; phosphoELM |
| Y209 | KHYQPyAPPRD | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y206 | PTRKHyQPYAP | ITK | HPRD; RegPhos |
| Y206 | PTRKHyQPYAP | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y218 | RDFAAyRS___ | PhosphoSitePlus | |
| Y209 | KHYQPyAPPRD | ITK | HPRD; phosphoELM; RegPhos |
| S220 | FAAYRs_____ | PhosphoSitePlus | |
| Y191 | LLHSDyMNMTP | Lck | phosphoELM; RegPhos |
| S189 | SRLLHsDYMNM | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| CD28_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000324890 | P121S | COSMIC | Head and Neck Cancer | 21984974 |
| Differential expressed protein |
| CD28_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CD28_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ITK_HUMAN | CD28_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| LCK_HUMAN | CD28_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | CD28_HUMAN | kinase -> substrate | RegPhos |
| CD86_HUMAN | CD28_HUMAN | other | KEGG |
| CD28_HUMAN | GRB2_HUMAN | other | KEGG |
| CD80_HUMAN | CD28_HUMAN | other | KEGG |
| CD28_HUMAN | CD80_HUMAN | other | KEGG |
| CD28_HUMAN | PI3R5_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05162 | Measles |
| hsa04940 | Type I diabetes mellitus |
| hsa05330 | Allograft rejection |
| hsa05416 | Viral myocarditis |
| hsa04672 | Intestinal immune network for IgA production |
| hsa04660 | T cell receptor signaling pathway |
| hsa05320 | Autoimmune thyroid disease |
| hsa05332 | Graft-versus-host disease |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa05322 | Systemic lupus erythematosus |
| hsa05323 | Rheumatoid arthritis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0002863 | positive regulation of inflammatory response to an | IEA | biological_process |
| GO:0042089 | cytokine biosynthetic process | TAS | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0002020 | protease binding | IPI | molecular_function |
| GO:0015026 | coreceptor activity | TAS | molecular_function |
| GO:0050690 | regulation of defense response to virus by virus | TAS | biological_process |
| GO:0045727 | positive regulation of translation | NAS | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0048304 | positive regulation of isotype switching to IgG is | IEA | biological_process |
| GO:0042802 | identical protein binding | NAS | molecular_function |
| GO:0045066 | regulatory T cell differentiation | IDA | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0045060 | negative thymic T cell selection | IEA | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0042102 | positive regulation of T cell proliferation | IDA | biological_process |
| GO:0005070 | SH3/SH2 adaptor activity | IDA | molecular_function |
| GO:0045840 | positive regulation of mitosis | IDA | biological_process |
| GO:0046641 | positive regulation of alpha-beta T cell prolifera | IEA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045070 | positive regulation of viral genome replication | NAS | biological_process |
| GO:0009897 | external side of plasma membrane | IDA | cellular_component |
| GO:0045086 | positive regulation of interleukin-2 biosynthetic | IDA | biological_process |
| GO:0031295 | T cell costimulation | IEA | biological_process |
| GO:0006959 | humoral immune response | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |