Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CASP9_HUMAN
Description:caspase 9, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1511]
Location:chr1 p36.21
Node attribute:PPI(target); cleavage(source); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S160DESPGsNPEPDHPRD
S99QAAKLsKPTLEPhosphoSitePlus
Y153NADLAyILSMEAblphosphoELM
T125VLRPEtPRPVDErk1(MAPK3RegPhos; SysPTM
T125VLRPEtPRPVDMAP2K1HPRD; RegPhos; SysPTM
S144VGALEsLRGNAPKCz(PKC zetaRegPhos
S144VGALEsLRGNAPRKCZHPRD
S310DESPGsNPEPDPeptidase_C14PhosphoSitePlus
T125VLRPEtPRPVDPhosphoSitePlus; phosphoELM; SysPTM
S310DESPGsNPEPDHPRD; phosphoELM
S152EVASTsPEDESHPRD
S144VGALEsLRGNAPhosphoSitePlus
S302EVASTsPEDESPeptidase_C14PhosphoSitePlus
S144VGALEsLRGNAPKC_zetaphosphoELM
S196RRRFSsLHFMVPKB_groupphosphoELM
T125VLRPEtPRPVDErk2(MAPK1RegPhos; SysPTM
S144VGALEsLRGNAPKCzRegPhos
Y153NADLAyILSMEABL1HPRD; RegPhos
S183RTRTGsNIDCEPeptidase_C14PhosphoSitePlus
S183RTRTGsNIDCEphosphoELM; RegPhos
T125VLRPEtPRPVDCDK1phosphoELM; SysPTM
S302EVASTsPEDESHPRD; phosphoELM
S196RRRFSsLHFMVAKT_groupRegPhos
S183RTRTGsNIDCEAKT1HPRD; RegPhos
S307SPEDEsPGSNPPeptidase_C14PhosphoSitePlus
T125VLRPEtPRPVDErk1RegPhos; SysPTM
S196RRRFSsLHFMVPeptidase_C14PhosphoSitePlus
T125VLRPEtPRPVDErk2RegPhos; SysPTM
S307SPEDEsPGSNPHPRD; phosphoELM
T125VLRPEtPRPVDMAPK1HPRD; phosphoELM; SysPTM
T125VLRPEtPRPVDMAPK3HPRD; phosphoELM; SysPTM
T125VLRPEtPRPVDMAP2K2HPRD; RegPhos; SysPTM
S157SPEDEsPGSNPHPRD
S195LRRRFsSLHFMPeptidase_C14PhosphoSitePlus
S175NFCREsGLRTRPeptidase_C14PhosphoSitePlus
Y153NADLAyILSMEPhosphoSitePlus
S196RRRFSsLHFMVAKT1HPRD; RegPhos

Dephosphorylation site
CASP9_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000330237G295VCOSMICRenal Cancer
ENSP00000330237G134ECOSMICCentral Nervous System Neoplasms18772890
ENSP00000330237Q245PCOSMICOvarian Cancer21720365

Differential expressed protein
CASP9_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CASP9_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANCASP9_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANCASP9_HUMANkinase -> substrateRegPhos
AKT1_HUMANCASP9_HUMANkinase -> substrateRegPhos
MP2K1_HUMANCASP9_HUMANkinase -> substrateHPRD; RegPhos
MK01_HUMANCASP9_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MP2K2_HUMANCASP9_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANCASP9_HUMANkinase -> substrateHPRD; RegPhos
KPCZ_HUMANCASP9_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
AKT3_HUMANCASP9_HUMANkinase -> substrateKEGG
CASP9_HUMANLYN_HUMANcleavageNetPath
APAF_HUMANCASP9_HUMANotherKEGG
CYC_HUMANCASP9_HUMANotherKEGG
CASP9_HUMANCASP3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05212Pancreatic cancer
hsa05416Viral myocarditis
hsa05164Influenza A
hsa05012Parkinson's disease
hsa05223Non-small cell lung cancer
hsa05134Legionellosis
hsa04210Apoptosis
hsa05213Endometrial cancer
hsa05222Small cell lung cancer
hsa04370VEGF signaling pathway
hsa05215Prostate cancer
hsa04115p53 signaling pathway
hsa05210Colorectal cancer
hsa05200Pathways in cancer
hsa05010Alzheimer's disease
hsa05145Toxoplasmosis
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05016Huntington's disease
hsa05152Tuberculosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042770signal transduction in response to DNA damageIDAbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0017124SH3 domain bindingIDAmolecular_function
GO:0009411response to UVIEAbiological_process
GO:0019901protein kinase bindingIDAmolecular_function
GO:0006919activation of cysteine-type endopeptidase activityIEAbiological_process
GO:0008635activation of cysteine-type endopeptidase activityTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0006915apoptotic processIEAbiological_process
GO:0008234cysteine-type peptidase activityIEAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0008233peptidase activityIDAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0034644cellular response to UVIDAbiological_process
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0008047enzyme activator activityTASmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0008630intrinsic apoptotic signaling pathway in response IMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004197cysteine-type endopeptidase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0043293apoptosomeIDAcellular_component
GO:2001020regulation of response to DNA damage stimulusIMPbiological_process
GO:0071549cellular response to dexamethasone stimulusIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0006974response to DNA damage stimulusIEAbiological_process


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