Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:APAF_HUMAN
Description:apoptotic peptidase activating factor 1 [Source:HGNC Symbol;Acc:576]
Location:chr12 q23.1
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S248DDVWDsWVLKANB-ARCPhosphoSitePlus
Y278VMGPKyVVPVENB-ARCPhosphoSitePlus
T1108TSADKtAKIWSWD40PhosphoSitePlus
S237DDVWDsWVLKAHPRD
S238RKHPRsLLILDNB-ARCPhosphoSitePlus
S357RIRKSsSYDYENB-ARCPhosphoSitePlus
S248DDVWDsWVLKAHPRD; phosphoELM
T204LQNLCtRLDQDHPRD; phosphoELM; SysPTM
S371EAMSIsVEMLRNB-ARCPhosphoSitePlus
T1103TKFSStSADKTWD40PhosphoSitePlus
Y382EDIKDyYTDLSNB-ARCPhosphoSitePlus
S268TTRDKsVTDSVNB-ARCPhosphoSitePlus
T48VRNEPtQQQRACARDPhosphoSitePlus
S238RKHPRsLLILDHPRD; phosphoELM
S272KSVTDsVMGPKNB-ARCPhosphoSitePlus
S369LDEAMsISVEMNB-ARCPhosphoSitePlus
T193LQNLCtRLDQDHPRD
Y383DIKDYyTDLSINB-ARCPhosphoSitePlus
S320KECKGsPLVVSNB-ARCPhosphoSitePlus
S227RKHPRsLLILDHPRD

Dephosphorylation site
APAF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353059D468NTCGAOvarian Cancer21720365, 18772890
ENSP00000448165E146VCOSMICOvarian Cancer21720365
ENSP00000353059E135VTCGAOvarian Cancer21720365, 18772890
ENSP00000448165D479NCOSMICOvarian Cancer21720365
ENSP00000448165K131MCOSMICLung Cancer

Differential expressed protein
APAF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
APAF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
APAF_HUMANCASP9_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05152Tuberculosis
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa05134Legionellosis
hsa04115p53 signaling pathway
hsa05222Small cell lung cancer
hsa04210Apoptosis
hsa05012Parkinson's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043531ADP bindingIEAmolecular_function
GO:0005794Golgi apparatusIDAcellular_component
GO:0007399nervous system developmentTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006919activation of cysteine-type endopeptidase activityIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0043293apoptosomeTAScellular_component
GO:0030900forebrain developmentIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0000166nucleotide bindingTASmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0008656cysteine-type endopeptidase activator activity invNASmolecular_function
GO:0006952defense responseIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0097193intrinsic apoptotic signaling pathwayTASbiological_process
GO:0006309apoptotic DNA fragmentationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0007420brain developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0001843neural tube closureIEAbiological_process
GO:0008635activation of cysteine-type endopeptidase activityIDAbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006919activation of cysteine-type endopeptidase activityIEAbiological_process
GO:0016505apoptotic protease activator activityIEAmolecular_function
GO:0051402neuron apoptotic processIEAbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0005737cytoplasmIDAcellular_component


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