| UniProt/SwissProt ID: | TR10B_HUMAN |
| Description: | tumor necrosis factor receptor superfamily, member 10b [Source:HGNC Symbol;Acc:11905] |
| Location: | chr8 p21.3 |
| Node attribute: | PPI(target); PPI(source); receptor; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y383 | HRDTLyTMLIK | Death | PhosphoSitePlus |
| T381 | AGHRDtLYTML | Death | PhosphoSitePlus |
| Dephosphorylation site |
| TR10B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000276431 | C97Y | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000317859 | C97Y | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000317859 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| TR10B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TNF10_HUMAN | TR10B_HUMAN | ligand -> receptor | HPMR |
| TR10B_HUMAN | CASP8_HUMAN | other | KEGG |
| TNF10_HUMAN | TR10B_HUMAN | other | KEGG |
| P53_HUMAN | TR10B_HUMAN | TF -> target gene | KEGG |
| P53_HUMAN | TR10B_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04115 | p53 signaling pathway |
| hsa05164 | Influenza A |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04210 | Apoptosis |
| hsa05162 | Measles |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006915 | apoptotic process | NAS | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0016021 | integral to membrane | IC | cellular_component |
| GO:0045569 | TRAIL binding | NAS | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0034976 | response to endoplasmic reticulum stress | IDA | biological_process |
| GO:0008625 | extrinsic apoptotic signaling pathway via death do | NAS | biological_process |
| GO:0006919 | activation of cysteine-type endopeptidase activity | TAS | biological_process |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB c | IEP | biological_process |
| GO:0007250 | activation of NF-kappaB-inducing kinase activity | NAS | biological_process |
| GO:0004872 | receptor activity | NAS | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0070059 | intrinsic apoptotic signaling pathway in response | IMP | biological_process |
| GO:0042981 | regulation of apoptotic process | NAS | biological_process |
| GO:0071260 | cellular response to mechanical stimulus | IEP | biological_process |