Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TR10B_HUMAN
Description:tumor necrosis factor receptor superfamily, member 10b [Source:HGNC Symbol;Acc:11905]
Location:chr8 p21.3
Node attribute:PPI(target); PPI(source); receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y383HRDTLyTMLIKDeathPhosphoSitePlus
T381AGHRDtLYTMLDeathPhosphoSitePlus

Dephosphorylation site
TR10B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000276431C97YBIOMARTBreast Cancer21930507, 21930502
ENSP00000317859C97YBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000317859Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
TR10B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TNF10_HUMANTR10B_HUMANligand -> receptorHPMR
TR10B_HUMANCASP8_HUMANotherKEGG
TNF10_HUMANTR10B_HUMANotherKEGG
P53_HUMANTR10B_HUMANTF -> target geneKEGG
P53_HUMANTR10B_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04115p53 signaling pathway
hsa05164Influenza A
hsa04060Cytokine-cytokine receptor interaction
hsa04210Apoptosis
hsa05162Measles

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006915apoptotic processNASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0016021integral to membraneICcellular_component
GO:0045569TRAIL bindingNASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0034976response to endoplasmic reticulum stressIDAbiological_process
GO:0008625extrinsic apoptotic signaling pathway via death doNASbiological_process
GO:0006919activation of cysteine-type endopeptidase activityTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0007250activation of NF-kappaB-inducing kinase activityNASbiological_process
GO:0004872receptor activityNASmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0070059intrinsic apoptotic signaling pathway in response IMPbiological_process
GO:0042981regulation of apoptotic processNASbiological_process
GO:0071260cellular response to mechanical stimulusIEPbiological_process


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