Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TRAF1_HUMAN
Description:TNF receptor-associated factor 1 [Source:HGNC Symbol;Acc:12031]
Location:chr9 q33.2
Node attribute:cleavage(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y310LCLRLyLNGDGMATHPhosphoSitePlus
T316LNGDGtGKRTHMATHPhosphoSitePlus
S66DLQSIsPGSRLPhosphoSitePlus; HPRD

Dephosphorylation site
TRAF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000443183V289ICOSMICOvarian Cancer21720365
ENSP00000443183F265VCOSMICOvarian Cancer21720365
ENSP00000362994F265VCOSMICOvarian Cancer21720365
ENSP00000362994I65VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000362994V289ICOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000362994Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.1515169874

Hyperphosphorylation site
TRAF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CASP8_HUMANTRAF1_HUMANcleavageNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer
hsa05203Viral carcinogenesis
hsa05168Herpes simplex infection
hsa04064NF-kappa B signaling pathway
hsa05169Epstein-Barr virus infection
hsa05222Small cell lung cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006461protein complex assemblyTASbiological_process
GO:0031996thioesterase bindingIPImolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0042981regulation of apoptotic processIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cRCAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0005737cytoplasmTAScellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23