| UniProt/SwissProt ID: | TRAF1_HUMAN |
| Description: | TNF receptor-associated factor 1 [Source:HGNC Symbol;Acc:12031] |
| Location: | chr9 q33.2 |
| Node attribute: | cleavage(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y310 | LCLRLyLNGDG | MATH | PhosphoSitePlus |
| T316 | LNGDGtGKRTH | MATH | PhosphoSitePlus |
| S66 | DLQSIsPGSRL | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| TRAF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000443183 | V289I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000443183 | F265V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000362994 | F265V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000362994 | I65V | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000362994 | V289I | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000362994 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 3 hour) | cell line | Down | 0.15 | 15169874 |
| Hyperphosphorylation site |
| TRAF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CASP8_HUMAN | TRAF1_HUMAN | cleavage | NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05200 | Pathways in cancer |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05203 | Viral carcinogenesis |
| hsa05168 | Herpes simplex infection |
| hsa04064 | NF-kappa B signaling pathway |
| hsa05169 | Epstein-Barr virus infection |
| hsa05222 | Small cell lung cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006461 | protein complex assembly | TAS | biological_process |
| GO:0031996 | thioesterase binding | IPI | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0042981 | regulation of apoptotic process | IDA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB c | RCA | biological_process |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051092 | positive regulation of NF-kappaB transcription fac | IDA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0031625 | ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | TAS | cellular_component |