Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IL1R1_HUMAN
Description:interleukin 1 receptor, type I [Source:HGNC Symbol;Acc:5993]
Location:chr2 q11.2
Node attribute:PPI(target); receptor; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y496EKIQDyEKMPETIRPhosphoSitePlus
T556LLSPAtKEKLQHPRD
Y496EKIQDyEKMPEphosphoELM

Dephosphorylation site
IL1R1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000386380C121RBIOMARTBreast Cancer21930507, 21930502
ENSP00000233946R543WBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000233946C121RBIOMARTBreast Cancer21930507, 21930502
ENSP00000233946D271NCOSMICMelanoma21499247

Differential expressed protein
IL1R1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IL1R1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IL1A_HUMANIL1R1_HUMANligand -> receptorHPMR
IL1B_HUMANIL1R1_HUMANligand -> receptorHPMR
IL1R1_HUMANTRAF6_HUMANotherKEGG
IL1R1_HUMANTAB1_HUMANotherKEGG
IL1A_HUMANIL1R1_HUMANotherKEGG
IL1R1_HUMANCASP3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04010MAPK signaling pathway
hsa05146Amoebiasis
hsa04210Apoptosis
hsa04380Osteoclast differentiation
hsa04640Hematopoietic cell lineage
hsa04064NF-kappa B signaling pathway
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004909interleukin-1, Type I, activating receptor activitIEAmolecular_function
GO:0045087innate immune responseIEAbiological_process
GO:0070498interleukin-1-mediated signaling pathwayIDAbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0002020protease bindingIEAmolecular_function
GO:0016020membraneIDAcellular_component
GO:0006955immune responseTASbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0004871signal transducer activityTASmolecular_function
GO:0005576extracellular regionIEAcellular_component
GO:0004908interleukin-1 receptor activityIDAmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0005161platelet-derived growth factor receptor bindingIPImolecular_function
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0004888transmembrane signaling receptor activityTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0070555response to interleukin-1IDAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0004908interleukin-1 receptor activityIEAmolecular_function


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