| UniProt/SwissProt ID: | IL1R1_HUMAN |
| Description: | interleukin 1 receptor, type I [Source:HGNC Symbol;Acc:5993] |
| Location: | chr2 q11.2 |
| Node attribute: | PPI(target); receptor; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y496 | EKIQDyEKMPE | TIR | PhosphoSitePlus |
| T556 | LLSPAtKEKLQ | HPRD | |
| Y496 | EKIQDyEKMPE | phosphoELM | |
| Dephosphorylation site |
| IL1R1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000386380 | C121R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000233946 | R543W | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000233946 | C121R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000233946 | D271N | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| IL1R1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IL1R1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IL1A_HUMAN | IL1R1_HUMAN | ligand -> receptor | HPMR |
| IL1B_HUMAN | IL1R1_HUMAN | ligand -> receptor | HPMR |
| IL1R1_HUMAN | TRAF6_HUMAN | other | KEGG |
| IL1R1_HUMAN | TAB1_HUMAN | other | KEGG |
| IL1A_HUMAN | IL1R1_HUMAN | other | KEGG |
| IL1R1_HUMAN | CASP3_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04010 | MAPK signaling pathway |
| hsa05146 | Amoebiasis |
| hsa04210 | Apoptosis |
| hsa04380 | Osteoclast differentiation |
| hsa04640 | Hematopoietic cell lineage |
| hsa04064 | NF-kappa B signaling pathway |
| hsa05166 | HTLV-I infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004909 | interleukin-1, Type I, activating receptor activit | IEA | molecular_function |
| GO:0045087 | innate immune response | IEA | biological_process |
| GO:0070498 | interleukin-1-mediated signaling pathway | IDA | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | IEA | biological_process |
| GO:0002020 | protease binding | IEA | molecular_function |
| GO:0016020 | membrane | IDA | cellular_component |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0009986 | cell surface | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004871 | signal transducer activity | TAS | molecular_function |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0004908 | interleukin-1 receptor activity | IDA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005161 | platelet-derived growth factor receptor binding | IPI | molecular_function |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0004888 | transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0070555 | response to interleukin-1 | IDA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004908 | interleukin-1 receptor activity | IEA | molecular_function |