| UniProt/SwissProt ID: | BID_HUMAN |
| Description: | BH3 interacting domain death agonist [Source:HGNC Symbol;Acc:1050] |
| Location: | chr22 q11.21 |
| Node attribute: | PPI(target); substrate; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T59 | YDELQtDGNRS | CK2a1-rs | RegPhos |
| T59 | YDELQtDGNRS | CSNK2A2 | HPRD |
| S64 | TDGNRsSHSRL | CSNK1A1 | HPRD |
| S64 | TDGNRsSHSRL | CSNK2A1 | HPRD |
| T59 | YDELQtDGNRS | CSNK2A1 | HPRD |
| S64 | TDGNRsSHSRL | P67870(Casein kinase II ) | RegPhos |
| S64 | TDGNRsSHSRL | CK2a2 | RegPhos |
| S64 | TDGNRsSHSRL | CSNK2A2 | HPRD |
| Y100 | PQWEGyDELQT | HPRD | |
| S78 | EADSEsQEDII | BID | PhosphoSitePlus |
| S64 | TDGNRsSHSRL | CK1a | RegPhos |
| S64 | TDGNRsSHSRL | CK1_group | phosphoELM; RegPhos |
| T59 | YDELQtDGNRS | CK1_group | phosphoELM; RegPhos |
| T59 | YDELQtDGNRS | CK1a | RegPhos |
| T59 | YDELQtDGNRS | CK1e | RegPhos |
| Y54 | PQWEGyDELQT | HPRD; phosphoELM; RegPhos | |
| T59 | YDELQtDGNRS | CSNK2B | HPRD |
| T59 | YDELQtDGNRS | CSNK1A1 | HPRD |
| T59 | YDELQtDGNRS | CK2a2 | RegPhos |
| S78 | EADSEsQEDII | HPRD; phosphoELM; RegPhos | |
| T59 | YDELQtDGNRS | CSNK1E | HPRD |
| S64 | TDGNRsSHSRL | CK1e | RegPhos |
| T59 | YDELQtDGNRS | BID | PhosphoSitePlus |
| T59 | YDELQtDGNRS | P67870(Casein kinase II ) | RegPhos |
| S124 | EADSEsQEDII | HPRD | |
| S64 | TDGNRsSHSRL | CK2a1 | RegPhos |
| Y54 | PQWEGyDELQT | BID | PhosphoSitePlus |
| T59 | YDELQtDGNRS | CK2_group | phosphoELM; RegPhos |
| T59 | YDELQtDGNRS | CK2a1 | RegPhos |
| S64 | TDGNRsSHSRL | CK2a1-rs | RegPhos |
| S64 | TDGNRsSHSRL | CSNK2B | HPRD |
| S64 | TDGNRsSHSRL | CK2_group | phosphoELM; RegPhos |
| S64 | TDGNRsSHSRL | CSNK1E | HPRD |
| Dephosphorylation site |
| BID_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000318822 | S110T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000318822 | *242S | COSMIC | Breast Cancer | 16959974 |
| Differential expressed protein |
| BID_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BID_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KC1A_HUMAN | BID_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | BID_HUMAN | kinase -> substrate | RegPhos |
| CSK2B_HUMAN | BID_HUMAN | kinase -> substrate | HPRD |
| CSK22_HUMAN | BID_HUMAN | kinase -> substrate | HPRD |
| KC1E_HUMAN | BID_HUMAN | kinase -> substrate | HPRD |
| CSK21_HUMAN | BID_HUMAN | kinase -> substrate | HPRD |
| CASP8_HUMAN | BID_HUMAN | other | NetPath |
| CASP8_HUMAN | BID_HUMAN | other | KEGG |
| BID_HUMAN | CYC_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa05152 | Tuberculosis |
| hsa04210 | Apoptosis |
| hsa04115 | p53 signaling pathway |
| hsa05416 | Viral myocarditis |
| hsa05010 | Alzheimer's disease |
| hsa05200 | Pathways in cancer |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032464 | positive regulation of protein homooligomerization | IDA | biological_process |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0043065 | positive regulation of apoptotic process | IMP | biological_process |
| GO:0001836 | release of cytochrome c from mitochondria | IEA | biological_process |
| GO:0005741 | mitochondrial outer membrane | TAS | cellular_component |
| GO:0042127 | regulation of cell proliferation | IEA | biological_process |
| GO:0008637 | apoptotic mitochondrial changes | TAS | biological_process |
| GO:2001238 | positive regulation of extrinsic apoptotic signali | IMP | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0008637 | apoptotic mitochondrial changes | IEA | biological_process |
| GO:2000045 | regulation of G1/S transition of mitotic cell cycl | IEA | biological_process |
| GO:0001836 | release of cytochrome c from mitochondria | IDA | biological_process |
| GO:0005739 | mitochondrion | TAS | cellular_component |
| GO:0051402 | neuron apoptotic process | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005123 | death receptor binding | TAS | molecular_function |
| GO:0032592 | integral to mitochondrial membrane | IEA | cellular_component |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0032461 | positive regulation of protein oligomerization | IDA | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0034349 | glial cell apoptotic process | IEA | biological_process |
| GO:0090150 | establishment of protein localization to membrane | IDA | biological_process |
| GO:0031625 | ubiquitin protein ligase binding | IEA | molecular_function |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0007420 | brain development | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0090200 | positive regulation of release of cytochrome c fro | IMP | biological_process |
| GO:0051260 | protein homooligomerization | IEA | biological_process |
| GO:0043065 | positive regulation of apoptotic process | IEA | biological_process |
| GO:0008625 | extrinsic apoptotic signaling pathway via death do | TAS | biological_process |
| GO:0032355 | response to estradiol stimulus | IEA | biological_process |
| GO:0006626 | protein targeting to mitochondrion | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0046902 | regulation of mitochondrial membrane permeability | IEA | biological_process |